| Interacting proteins: Q9P0L2 and Q15831 |
Pubmed |
SVM Score :0.0 |
| Mutation screening at the RNA level of the STK11 / LKB1 gene in Peutz Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform ( STK 11 c . 597 ( insertion mark ) 598insIVS4 ) . ^^^ In the course of our RNA based analyses we detected high level expression of a novel STK11 / LKB1 mRNA variant retaining intron 4 ( STK 11 c . 597 ( insertion mark ) 598insIVS4 ) in various tissues . ^^^ |
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| Interacting proteins: Q9P0L2 and Q15831 |
Pubmed |
SVM Score :0.0 |
| Ten of the 14 AMPK related protein kinases activated by LKB 1 , including SIK ( salt induced kinase ) , MARK ( microtubule affinity regulating kinase ) and BRSK ( brain specific kinase ) isoforms , possess a ubiquitin associated ( UBA ) domain immediately C terminal to the kinase catalytic domain . ^^^ SAXS ( small angle 10 ray scattering ) analysis of inactive and active LKB 1 phosphorylated MARK 2 revealed that activation of MARK 2 is accompanied by a significant conformational change that alters the orientation of the UBA domain with respect to the catalytic domain . ^^^ This is based on the findings that mutation or removal of the UBA domains of several AMPK related kinases , including isoforms of MARK , SIK and BRSK , markedly impaired the catalytic activity and LKB 1 mediated phosphorylation of these enzymes . ^^^ |
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| Interacting proteins: Q9P0L2 and Q15831 |
Pubmed |
SVM Score :0.0 |
| Activities of endogenous NUAK 2 , QIK , QSK , SIK , MARK 1 , MARK2 / 3 and MARK 4 were markedly reduced in LKB 1 deficient cells . ^^^ |
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