| Interacting proteins: Q15831 and Q13315 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that both DNA PK and ATM efficiently phosphorylate LKB 1 at Thr 366 in vitro and provide evidence that ATM mediates this phosphorylation in vivo . ^^^ This is based on the finding that LKB 1 is not phosphorylated in a cell line lacking ATM in response to IR , and that agents which induce cellular responses via ATR in preference to ATM poorly induce phosphorylation of LKB 1 at Thr 366 . ^^^ These observations provide the first link between ATM and LKB 1 and suggest that ATM could regulate LKB1 . . ^^^ |
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| Interacting proteins: Q15831 and Q13315 |
Pubmed |
SVM Score :0.0 |
| The past 15 years has seen the establishment of mouse lines heterozygous or homozygous null for genes known or suspected of being involved in human cancer syndromes , including APC , ATM , BLM , BRCA 1 , BRCA 2 , LKB 1 , MEN 1 , MLH , MSH , NF 1 , TP 53 , PTEN , RB 1 , TSC 1 , TSC 2 , VHL , and XPA . ^^^ |
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| Interacting proteins: Q15831 and Q13315 |
Pubmed |
SVM Score :0.0 |
| IGF 1 phosphorylates AMPK alpha subunit in ATM dependent and LKB 1 independent manner . ^^^ These results suggest that IGF 1 induces AMPK alpha subunit phosphorylation via an ATM dependent and LKB 1 independent pathway . . ^^^ |
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| Interacting proteins: Q15831 and Q13315 |
Pubmed |
SVM Score :0.0 |
| Furthermore , wild type ATM displayed DNA damage induced association with p 53 , brca 1 , and LKB 1 in vivo , whereas ATM 90 failed to form productive complexes with these target proteins either in vivo or in vitro . ^^^ We propose that amino acids 91 97 of ATM contain a protein interaction domain required for the DNA damage induced association between ATM and its target proteins , including the brca 1 , p 53 , and LKB 1 proteins . ^^^ |
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| Interacting proteins: Q15831 and Q13315 |
Pubmed |
SVM Score :0.0 |
| Additionally , we summarized breast cancer risk associated with the following genetic factors : breast cancer susceptibility high penetrance genes ( BRCA 1 , BRCA 2 , p 53 , PTEN , ATM , NBS 1 or LKB 1 ) and low penetrance genes such as cytochrome P 450 genes ( CYP1A1 , CYP2D6 , CYP 19 ) , glutathione S transferase family ( GSTM 1 , GSTP 1 ) , alcohol and one carbon metabolism genes ( ADH1C and MTHFR ) , DNA repair genes ( XRCC 1 , XRCC 3 , ERCC4 / XPF ) and genes encoding cell signaling molecules ( PR , ER , TNFalpha or HSP 70 ) . ^^^ |
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| Interacting proteins: Q15831 and Q13315 |
Pubmed |
SVM Score :0.0 |
| Most women with a family history of breast / ovarian cancer have tumors characterized by alterations in particular genes , mainly BRCA 1 and BRCA 2 , but also CHK 2 , ATM , STK 11 and others . ^^^ |
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| Interacting proteins: Q15831 and Q13315 |
Pubmed |
SVM Score :0.0 |
| Other hereditary disorders predisposing to PC include Peutz Jeghers syndrome , due to the STK 11 mutation , familial pancreatitis due to the cationic trypsinogen gene , site specific familial pancreatic cancer which may be due to the 4q32 34 mutation , hereditary breast ovarian cancer ( HBOC ) syndrome that is due to BRCA 2 and possibly some families with HBOC that is due to BRCA 1 , familial adenomatous polyposis due to the ATP gene , and ataxia telangiectasia due to the ATM germline mutation . ^^^ |
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| Interacting proteins: Q15831 and Q13315 |
Pubmed |
SVM Score :0.0 |
| NA |
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