| Carney complex ( CC ) , Peutz Jeghers syndrome ( PJS ) , Cowden disease ( CD ) , and Bannayan Zonana syndrome ( BZS ) share clinical features , such as mucocutaneous lentigines and multiple tumors ( thyroid , breast , ovarian , and testicular neoplasms ) , and autosomal dominant inheritance . ^^^ A genetic locus has been identified for CC on chromosome 2 ( 2p16 ) , and the genes for PJS , CD , and BZS were recently identified ; genetic heterogeneity appears likely in both CC and PJS . ^^^ The genes for PJS and CD / BZS , STK11 / LKB1 and PTEN , respectively , may act as tumor suppressors , because loss of heterozygosity ( LOH ) of the PJS and CD / BZS loci has been demonstrated in tumors excised from patients with these disorders . ^^^ We also tested 16 tumors and cell lines established from patients with CC for LOH involving the PJS and CD / BZS loci . ^^^ The overall rate of LOH for the PJS and CD / BZS loci in tumors from patients with CC was less than 10 % . ^^^ |