| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Here , it is shown that PPARgamma coactivator 1 ( PGC 1 ) promotes transcription through the assembly of a complex that includes the histone acetyltransferases steroid receptor coactivator 1 ( SRC 1 ) and CREB binding protein ( CBP ) / p300 . ^^^ The docking of PGC 1 to peroxisome proliferator activated receptor gamma ( PPARgamma ) stimulates an apparent conformational change in PGC 1 that permits binding of SRC 1 and CBP / p300 , resulting in a large increase in transcriptional activity . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| We have explored the interaction of several known ligands and the nuclear receptor ( peroxisome proliferator activated receptor alpha , PPARalpha ) using scintillation proximity assay ( SPA ) and the interaction of LXXLL containing peptides derived from three coactivators ( SRC 1 , CBP and PGC 1 ) with PPARalpha in the presence of PPARalpha agonist ligands using fluorescence resonance energy transfer ( FRET ) . ^^^ Similarly , for all ligands tested , the rank order of EC ( 50 ) for peptide recruitment was CBP < PGC 1 < SRC 1 . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| PRIC complex includes known coactivators or coactivator binding proteins ( CBP , SRC 1 , PBP , PRIP , PIMT , TRAP 100 , SUR 2 , and PGC 1 ) , other proteins that have not previously been described in association with transcription complexes ( CHD 5 , TOG , and MORF ) , and a few novel polypeptides designated PRIC 300 , 285 , 215 , 177 , and 145 . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| The decrease in expression of RXRalpha , beta , and gamma , PPARalpha and delta , and TRalpha and beta , and of the coactivators CBP / p300 , SRC 1 , SRC 3 , TRAP 220 , and PGC 1 and the genes they regulate , induced by LPS in the heart , could account for the decreased expression of key proteins required for fatty acid oxidation and thereby play an important role in cardiac contractility . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| However , clear differences were observed among the splice variants when dose response curves were compared by the assay in the presence of coactivators such as SRC 1 and PGC 1 . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| The role of transcriptional cofactors , such as SRC 1 and PGC 1 , in mediating the gene specific effects of individual nuclear receptors is becoming increasingly evident . . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Competition experiments of the complex between ERalpha and fluorescently labelled PGC 1 91 408 with unlabelled SRC 1 570 780 showed that PGC 1 91 408 was an efficient competitor of SRC 1 570 780 , while the inverse was not true , underscoring their distinct modes of binding . ^^^ The anisotropy data provide strong evidence for a ternary complex between ERalpha , SRC 1 570 780 and PGC 1 91 408 . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| We now report that PIMT strongly interacts with transcriptional coactivators , CBP , p 300 , and PBP but not with SRC 1 and PGC 1alpha under in vitro and in vivo conditions . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| In white adipose tissue , lack of TIF 2 decreases PPARgamma activity and reduces fat accumulation , whereas in brown adipose tissue it facilitates the interaction between SRC 1 and PGC 1alpha , which induces PGC 1alpha ' s thermogenic activity . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated recetor gamma ( PPARgamma ) and its coactivators , PGC 1alpha and SRC 1 , influence brown adipocyte metabolism and development . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that a PGC 1alpha peptide containing this nuclear box motif from the L 3 site binds ERRalpha LBD with a higher affinity than a peptide containing a steroid receptor coactivator 1 motif and that the affinity is further enhanced when all three leucine rich regions of PGC 1alpha are present . . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| The amount of CBP ( CREB binding protein ) and SRC 1 ( steroid receptor coactivator 1 ) recruited by FK 614 was less than that induced by rosiglitazone and pioglitazone , but FK 614 caused similar PGC 1alpha ( PPARgamma coactivator 1alpha ) recruitment as these compounds . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Rifampicin strongly stimulated PXR and hepatocyte nuclear factor 4alpha ( HNF4alpha ) interaction , and CYP3A4 reporter activity , which was further stimulated by peroxisome proliferators activated receptorgamma co activator 1alpha ( PGC 1alpha ) and steroid receptor coactivator 1 ( SRC 1 ) but inhibited by SHP . ^^^ Results suggest that PXR strongly induces CYP3A4 gene transcription by interacting with HNF4alpha , SRC 1 , and PGC 1alpha . ^^^ |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBK2 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
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