| Interacting proteins: Q96RI1 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Upon activation , FXR heterodimerizes with the 9 cis retinoic 10 receptor ( RXR ) and regulates genes involved in cholesterol and BA homeostasis . 6 Ethyl CDCA ( 6 ECDCA ) is a synthetic BA that binds FXR and induces gene transcription by recruiting coactivators , such as steroid receptor coactivator 1 , with histone acetyltransferase activity . ^^^ |
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| Interacting proteins: Q96RI1 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Nuclear magnetic resonance spectroscopy demonstrated the direct binding of androsterone to purified human FXR ( hFXR ) ligand binding domain ( LBD ) protein , resulting in the recruitment of steroid receptor coactivator protein 1 ( SRC 1 ) coactivator peptide . ^^^ |
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| Interacting proteins: Q96RI1 and Q15788 |
Pubmed |
SVM Score :0.0 |
| This study compares the potencies of various bile acids in their ability to mediate recruitment of the transcriptional coactivator protein , steroid receptor coactivator 1 ( SRC 1 ) , to the FXR ligand binding domain with their ability to repress CYP7A1 expression in HepG 2 cells . ^^^ A mammalian two hybrid assay was utilized to assess the ability of FXR to recruit SRC 1 in a ligand dependent manner . ^^^ |
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| Interacting proteins: Q96RI1 and Q15788 |
Pubmed |
SVM Score :0.0 |
| From an optimized assay , a saturated hyperbolic fluorescence signal curve was produced when 250 nM of FXR 33 and 100 nM of steroid receptor coactivator 1 peptide , a coactivator of FXR consisting of 26 amino acids , were used with a concentration dependence on chenodeoxycholic acid ( from 0 to 200 microM ) . ^^^ |
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| Interacting proteins: Q96RI1 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96RI1 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96RI1 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
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