Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
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Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.72505108
In addition , CBP associates with two other TSs , P / CAF and SRC 1 . 0.72505108^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.5505575
We also demonstrated functional differentiation between CBP and other coactivators , including SRC 1 and the CBP related protein p 300 , both of which influenced GR signaling in a positive fashion . 0.5505575^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :1.0175831
A C terminal domain of CBP ( referred to as the SID ) is responsible for interaction with the alpha helical AD 1 domain of p 160 coactivators such as the steroid receptor coactivator ( SRC 1 ) , and also other transcriptional regulators such as E1A , Ets 2 , IRF 3 , and p 53 . 1.0175831^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.60474983
Prominent in this diverse group is the steroid receptor coactivator 1 ( SRC 1 ) family , which interact with agonist bound nuclear receptors , thereby coupling them to multifunctional transcriptional coregulators such as CREB binding protein ( CBP ) , p 300 , and PCAF , all of which have potent histone acetyltransferase activity . 0.60474983^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The two coactivators p300 / CBP and NCoA 1 cooperatively enhance STAT5a mediated transactivation . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The coactivators used in this study contained CBP , p 300 , RIP 140 , SRC 1 , TIF 1 , and TIF 2 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Accordingly , ERalpha dephosphorylation decreases its ligand independent interaction with SRC 1 and CBP in vitro . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The highly related nuclear receptor co activator protein NCoA 1 is also specifically required for ligand dependent activation of genes by nuclear receptors . p / CIP , NCoA 1 and CBP all contain related leucine rich charged helical interaction motifs that are required for receptor specific mechanisms of gene activation , and allow the selective inhibition of distinct signal transduction pathways . . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
In addition , we showed that both coactivators CBP and NCoA 1 bind independently to specific regions within the STAT 6 transactivation domain . ^^^ Our results suggest that multiple contacts between NCoA 1 , CBP , and STAT 6 are required for transcriptional activation . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The CREB binding protein and the nuclear coactivator 1 ( NCoA 1 ) , a member of the p160 / steroid receptor coactivator family , bind independently to specific regions of STAT 6 and act as coactivators . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The CREB binding protein ( p300 / CBP ) and the nuclear coactivator 1 ( NCoA 1 ) , a member of the p160 / steroid receptor coactivator family , bind independently to specific regions of the STAT 6 transactivation domain and act as coactivators . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Utilizing distinct domains , CBP directly interacts with the ligand binding domain of multiple nuclear receptors and with the p 160 nuclear receptor coactivators , which upon cloning have proven to be variants of the SRC 1 protein . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Coexpression of CBP and SRC 1 stimulated ER and PR transcriptional activity in a synergistic manner and indicated that these two coactivators are not functional homologues . ^^^ Taken together , these data suggest that both CBP and SRC 1 may function in a common pathway to efficiently activate target gene expression . . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The nuclear hormone receptor coactivator SRC 1 is a specific target of p 300 . p 300 and its family member , CREB binding protein ( CBP ) , function as key transcriptional coactivators by virtue of their interaction with the activated forms of certain transcription factors . ^^^ In a search for additional cellular targets of p300 / CBP , a protein protein cloning strategy , surprisingly identified SRC 1 , a coactivator involved in nuclear hormone receptor transcriptional activity , as a p300 / CBP interactive protein . p 300 and SRC 1 interact , specifically , in vitro and they also form complexes in vivo . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
CBP and SRC 1 interact and synergistically enhance transcriptional activation by the ER and PR . ^^^ Therefore , a ternary complex consisting of CBP , SRC 1 , and liganded steroid receptors may form to increase the rate of hormone responsive gene transcription . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Several nuclear receptor coactivators ( CBP , F SRC 1 , SRC 1 , and RIP 140 ) that interact with other steroid receptors were tested as potential mediators of the N and C terminal interaction of rAR using the mammalian two hybrid system . ^^^ CBP or F SRC 1 not only enhanced AR mediated transactivation , but also facilitated the androgen dependent interaction between the N and C terminal domains , implying that part of the coactivator dependent transcriptional activation occurs via this mechanism . ^^^ Recruitment of coregulators may involve AR domains other than the LBD , as F SRC 1 and CBP enhanced , but SRC 1 repressed , the transcriptional activity of ARDelta 641 902 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Furthermore , SRC 1 , together with the cAMP responsive element binding protein ( CBP ) or a closely related factor , p 300 , synergistically enhanced transcriptional activity of GAL 4 SF 1 . ^^^ We conclude that the carboxy terminal AF 2 region of SF 1 functions as an activation domain and that SRC 1 and CBP / p300 are components of the coactivator complex with SF 1 . . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The p 50 binding site was localized to a subregion of SRC 1 ( amino acids 759 1141 ) that encompasses the previously described CBP p 300 binding domain . ^^^ Coexpression of p 300 further enhanced this SRC 1 potentiated level of transactivations , consistent with the recent findings in which CBP and p 300 were shown to be transcription coactivators of the p 65 subunit ( Perkins , N . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Expression of the coactivators SRC 1 and CREB binding protein , which bind to PPAR , also enhanced the responsiveness of the prolactin promoter to PPARalpha . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Using the ligand binding domain ( LBD ) of peroxisome proliferator activated receptor ( PPARgamma ) as a model , known agonists ( thiazolidinediones and delta 12 , 14 PGJ 2 ) induced a specific interaction resulting in FRET between the fluorescently labeled LBD and fluorescently labeled coactivators [ CREB binding protein ( CBP ) or steroid receptor coactivator 1 ( SRC 1 ) ] . ^^^ A site directed AF 2 mutant of PPARgamma ( E471A ) that abrogated ligand stimulated transcription in transfected cells also failed to induce ligand mediated FRET between PPARgamma LBD and CBP or SRC 1 . ^^^ In the presence of saturating agonist concentrations , unlabeled CBP or SRC 1 was used to compete with fluorescently labeled coactivators with saturation kinetics . ^^^ Relative affinities for the individual receptor coactivator pairs were determined as follows : PPARgamma CBP = ERalpha SRC 1 > PPARgamma SRC 1 > > ERalpha CBP . ^^^ CONCLUSIONS : 1 ) FRET based coactivator association is a novel approach for characterizing nuclear receptor agonists or antagonists ; individual ligands display potencies that are predictive of in vivo effects and distinct profiles of maximal activity that are suggestive of alternative receptor conformations . 2 ) PPARgamma interacts with both CBP and SRC 1 ; transcriptional activation and coactivator association are AF 2 dependent . 3 ) Nuclear receptor LBDs have distinct affinities for individual coactivators ; thus , PPARgamma has a greater apparent affinity for CBP than for SRC 1 , whereas ERalpha interacts preferentially with SRC 1 but very weakly with CBP . . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Both of these transcriptional activators depend upon the coactivators CREB binding protein ( CBP ) and steroid receptor coactivator 1 ( SRC 1 ) for maximal activity . ^^^ We propose that cross talk between the p 65 component of NF kappaB and glucocorticoid receptors is due , at least in part , to nuclear competition for limiting amounts of the coactivators CBP and SRC 1 , thus providing a novel mechanism for decreasing expression of genes involved in the inflammatory response . . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
We also show that overexpression of the steroid receptor coactivator ( SRC 1 ) potentiates transactivation by genistein activated ER alpha and that coexpression of CBP ( the cAMP response element binding protein coactivator ) synergistically increases this signal . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Finally , we demonstrate that the coactivators CBP and SRC 1 are limiting with respect to cAMP induced CRS 2 dependent transcription in Y 1 adrenocortical tumor cells , suggesting that part of the action of cAMP may be to influence the interaction of SF 1 with other cofactors via the AF 2 domain . . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Coactivators previously implicated in ligand dependent activation functions by thyroid hormone receptor ( TR ) include p 300 and CREB binding protein ( CBP ) , the steroid receptor coactivator 1 ( SRC 1 ) related family of proteins , and the multicomponent TR associated protein ( TRAP ) complex . ^^^ Furthermore , neither the pleiotropic coactivators CBP and p 300 nor members of the SRC 1 family were detected in either the TR TRAP complex or the other components of the in vitro assay system . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Coexpression of steroid receptor coactivator 1 ( SRC 1 ) and the CREB binding protein ( CBP ) , enhanced functional interaction between N and C domains by mammalian two hybrid assay . ^^^ However , addition of SRC 1 and CBP in vitro had no influence on direct interaction between purified N and C domains . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Indeed , expression of the coactivators , steroid hormone receptor coactivator 1 ( SRC 1 ) and CREB binding protein ( CBP ) , significantly enhances the stimulatory effect of vitamin D mediated by the wild type VDR but not by the AF 2 mutant receptor . ^^^ Synergistic activation of the prolactin promoter by vitamin D receptor and GHF 1 : role of the coactivators , CREB binding protein and steroid hormone receptor coactivator 1 ( SRC 1 ) . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Activating signal cointegrator 1 ( ASC 1 ) harbors an autonomous transactivation domain that contains a putative zinc finger motif which provides binding sites for basal transcription factors TBP and TFIIA , transcription integrators steroid receptor coactivator 1 ( SRC 1 ) and CBP p 300 , and nuclear receptors , as demonstrated by the glutathione S transferase pull down assays and the yeast two hybrid tests . ^^^ Nonetheless , ASC 1 appears to require the AF 2 dependent factors to function ( i . e . , CBP p 300 and SRC 1 ) , as suggested by the ability of ASC 1 to coactivate nuclear receptors , either alone or in cooperation with SRC 1 and p 300 , as well as its inability to coactivate a mutant receptor lacking the AF 2 core domain . ^^^ By using indirect immunofluorescence , we further show that ASC 1 , a nuclear protein , is localized to the cytoplasm under conditions of serum deprivation but is retained in the nucleus when it is serum starved in the presence of ligand or coexpressed CBP or SRC 1 . ^^^ These results suggest that ASC 1 is a novel coactivator molecule of nuclear receptors which functions in conjunction with CBP p 300 and SRC 1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions . . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Here , it is shown that PPARgamma coactivator 1 ( PGC 1 ) promotes transcription through the assembly of a complex that includes the histone acetyltransferases steroid receptor coactivator 1 ( SRC 1 ) and CREB binding protein ( CBP ) / p300 . ^^^ The docking of PGC 1 to peroxisome proliferator activated receptor gamma ( PPARgamma ) stimulates an apparent conformational change in PGC 1 that permits binding of SRC 1 and CBP / p300 , resulting in a large increase in transcriptional activity . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The hypoxia inducible activity of both these domains was enhanced by either SRC 1 or the CREB binding protein ( CBP ) / p300 coactivator . ^^^ Moreover , at limiting concentrations , SRC 1 produced this effect in synergy with CBP . ^^^ These data indicate that all three proteins , CBP , SRC 1 , and Ref 1 , are important components of the hypoxia signaling pathway and have a common function in regulation of HIF 1alpha function in hypoxic cells . ^^^ Given the absence of cysteine residues in one of the Ref 1 regulated transactivation domains of HIF 1alpha , it is thus possible that Ref 1 functions in hypoxic cells by targeting critical steps in the recruitment of the CBP SRC 1 coactivator complex . . ^^^ Redox regulated recruitment of the transcriptional coactivators CREB binding protein and SRC 1 to hypoxia inducible factor 1alpha . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Candidate factors have been identified by the observation that changes in glucocorticoid induction parameters in CV 1 cells could be reproduced by varying the cellular levels of coactivators [ transcriptional intermediary factor 2 ( TIF 2 ) , steroid receptor coactivator 1 ( SRC 1 ) , and amplified in breast cancer 1 ( AIB 1 ) ] , comodulator [ CREB binding protein ( CBP ) ] , or corepressor [ silencing mediator for retinoid and thyroid hormone receptors ( SMRT ) ] without concomitant increases in GR . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
We showed that for SRC 1 , CBP , TIF1alpha , RIP 140 , N CoR , and SMRT , no significant differences in the expression levels were observed between breast and endometrial cells . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Our results show that TR beta 2 , unlike TR beta 1 or TR alpha 1 , is able to bind certain coactivators ( CBP , SRC 1 , and pCIP ) in the absence of T ( 3 ) through a domain which maps to the amino terminal half of its A / B domain . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
In cotransfection studies in COS 7 cells , RIP 140 also inhibited receptor activity in presence of both SRC 1 and the coactivator protein CBP together . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Nuclear receptor activation is dependent on recruitment of coactivators , including CREB binding protein ( CBP / p300 ) and steroid receptor coactivator 1 ( SRC 1 ) . ^^^ Alanine mutants revealed that K301A , V315A , Y320A , L468A , and E471A were required for binding of both CBP and SRC 1 and for cell based transcription . ^^^ Several additional amino acids in helix 4 of the PPARgammaLBD were defective with respect to CBP recruitment , but retained relatively normal SRC 1 recruitment . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Here we provide evidence that the hormone occupied PR forms a multisubunit receptor coactivator complex containing two previously described coactivators , CREB binding protein ( CBP ) and steroid receptor coactivator 1 ( SRC 1 , a member of the p 160 family of coactivators ) , in nuclear extracts of human breast tumor T47D cells . ^^^ The association of CBP and SRC 1 / p160 with the receptor complex is entirely hormone dependent . ^^^ Both CBP and SRC 1 / p160 possess intrinsic histone acetyltransferase ( HAT ) activity , and it has been recently proposed that these coactivators function by modulating chromatin structure at the promoter of the target gene . ^^^ These results strongly implied that CBP and SRC 1 / p160 facilitate receptor mediated transcription in these cell extracts through mechanisms other than chromatin remodeling . ^^^ Most importantly , we noted that binding of E1A to CBP prevented the assembly of a coactivation complex containing PR , CBP , and SRC 1 / p160 , presumably by disrupting the interaction between CBP and SRC 1 / p160 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
To obtain some clue to these roles , we screened the expression levels of ER alpha , ER beta , coactivators ( SRC 1 , TIF 2 , AIB 1 , CBP , and P / CAF ) and corepressors ( N CoR and SMRT ) in 6 normal mammary glands , 6 intraductal carcinomas , 22 invasive ductal carcinomas , and 7 breast cancer cell lines using a multiplex reverse transcription PCR . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
In the present work , we investigate the effect of GC repression on different natural and / or recombinant NF kappaB driven reporter gene constructs in the presence of increasing amounts of various coactivator molecules , such as CREB binding protein ( CBP ) , p 300 , and SRC 1 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
In exploring the molecular mechanism involved in HNF 1 dependent gene activation in the in vivo chromatin context , we found that HNF 1 can physically interact with the histone acetyltransferases ( HATs ) CREB binding protein ( CBP ) , p300 / CBP associated factor ( P / CAF ) , Src 1 , and RAC 3 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Furthermore , using cotransfection and antisense technology we have found that , unlike SRC 1 and GRIP 1 , which are not involved in the GR complex that suppresses keratin genes , histone acetyltransferase and CBP are . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Confirmed and putative HAT proteins have been identified from various organisms from yeast to humans , and they include Gcn 5 related N acetyltransferase ( GNAT ) superfamily members Gcn 5 , PCAF , Elp 3 , Hpa 2 , and Hat 1 : MYST proteins Sas 2 , Sas 3 , Esa 1 , MOF , Tip 60 , MOZ , MORF , and HBO 1 ; global coactivators p 300 and CREB binding protein ; nuclear receptor coactivators SRC 1 , ACTR , and TIF 2 ; TATA binding protein associated factor TAF ( 2 ) 250 and its homologs ; and subunits of RNA polymerase 3 general factor TFIIIC . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
ASC 2 was recently discovered as a cancer amplified transcription coactivator molecule of nuclear receptors , which interacts with multifunctional transcription integrators steroid receptor coactivator 1 ( SRC 1 ) and CREB binding protein ( CBP ) / p300 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
CBP and p 300 are thought to be recruited to nuclear receptors through bridging factors that include SRC 1 , although CBP also interacts directly with PPARgamma through its amino terminus . ^^^ These observations have raised questions concerning the involvement of SRC 1 like factors in CBP recruitment and transrepression . ^^^ We here provide evidence that PPARgamma ' s ability to repress iNOS transcription requires the ligand dependent charge clamp that mediates interactions with CBP and SRC 1 . ^^^ Single amino acid mutations in PPARgamma that abolished ligand dependent interactions with SRC 1 and CBP not only resulted in complete loss of transactivation activity but also abolished transrepression . ^^^ Conversely , a CBP deletion mutant containing the SRC 1 interaction domain but lacking the N terminal PPARgamma interaction domain was inactive as a PPARgamma coactivator and failed to rescue transrepression . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
RESULTS : Ten of the 12 cofactors tested were expressed in all cells analyzed ( AIB 1 , ARA 54 , ARA 70 , CBP , cyclin D 1 , Her2 / neu / erbB2 , BAG 1 / M / L , SRC 1 , SMRT , and TIF 2 ) . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Bromo cyclic AMP induces phosphorylation of two sites in SRC 1 that facilitate ligand independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC 1 and CREB binding protein . ^^^ This was due , in part , to loss of functional cooperation between SRC 1 and CREB binding protein for coactivation of cPR ( A ) . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Our laboratory has previously demonstrated that retinoic acid nuclear receptor , thyroid transcription factor 1 ( TTF 1 ) , and nuclear receptor coactivators such as cAMP response element binding protein ( CREB ) binding protein ( CBP ) / p300 and steroid receptor coactivator 1 ( SRC 1 ) form an enhanceosome on the 5 ' enhancer region of the human surfactant protein B gene . ^^^ Immunohistochemistry was used to identify cells that coexpressed CBP / p300 , SRC 1 , retinoid 10 receptor , and TTF 1 in the developing and mature lung . ^^^ CBP / p300 and SRC 1 were expressed in the adult mouse lung , CBP and p 300 being present in both alveolar type 1 and type 2 epithelial cells and SRC 1 and TTF 1 being restricted to type 2 epithelial cells . ^^^ CBP / p300 , SRC 1 , and TTF 1 were readily detected in the nuclei of developing respiratory epithelial tubules in fetal mice from embryonic days 10 to 18 . ^^^ CBP / p300 and SRC 1 were also detected in developing mesenchymal cells . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
In yeast two hybrid assays , core LXXLL motif sequences derived from steroid receptor co activator ( SRC 1 ) , the 140 kDa receptor interacting protein ( RIP 140 ) , and CREB binding protein ( CBP ) displayed differences in selectivity and affinity for nuclear receptor ligand binding domains . ^^^ Although core LXXLL motifs from SRC 1 and RIP 140 mediated strong interactions with steroid and retinoid receptors , three LXXLL motifs present in the global co activator CBP were found to have very weak affinity for these proteins . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The transcriptional activity of nuclear receptors is mediated by coactivator proteins , including steroid receptor coactivator 1 ( SRC 1 ) and its homologues and the general coactivators CREB binding protein ( CBP ) and p 300 . ^^^ SRC 1 contains an activation domain ( AD 1 ) which functions via recruitment of CBP and and p 300 . ^^^ We also define a 72 amino acid sequence in CBP necessary for SRC 1 binding , designated the SRC 1 interaction domain ( SID ) . ^^^ We show that in contrast to SRC 1 , direct binding of CBP to the estrogen receptor is weak , suggesting that SRC 1 functions primarily as an adaptor to recruit CBP and p 300 . ^^^ Analysis of the steroid receptor coactivator 1 ( SRC 1 ) CREB binding protein interaction interface and its importance for the function of SRC 1 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Also found at the array by immunofluorescence were two different steroid receptor coactivators ( SRC 1 and CBP ) with acetyltransferase activity , a chromatin remodeler ( BRG 1 ) , and two transcription factors ( NFI and AP 2 ) . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The oncoprotein Tax binds the SRC 1 interacting domain of CBP / p300 to mediate transcriptional activation . ^^^ Interestingly , this domain corresponds to the steroid receptor coactivator 1 ( SRC 1 ) interacting domain of CBP . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Role of CBP / p300 and SRC 1 in transcriptional regulation of the pulmonary surfactant protein A ( SP A ) gene by thyroid transcription factor 1 ( TTF 1 ) . ^^^ In this study , we analyzed roles of CREB binding protein ( CBP ) and steroid receptor coactivator 1 ( SRC 1 ) in TTF 1 regulation of SP A expression . ^^^ Upon differentiation of human fetal lung in culture , nuclear localization of CBP , SRC 1 , and TTF 1 increased in ductular epithelium in association with type 2 cell differentiation and induction of SP A expression . ^^^ In transient transfections , CBP and SRC 1 acted synergistically with TTF 1 to increase SP A promoter activity . ^^^ Adenoviral E1A overexpression reduced TTF 1 + / SRC 1 induction of SP A promoter activity , suggesting a role of endogenous CBP / p300 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
However , the action of GT 198 was distinguishable from that of the ligand binding domain interacting nuclear receptor coactivators , such as TRBP , CBP , and SRC 1 , with respect to basal activation and hormone sensitivity . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The coactivator CARM 1 methylates histone H 3 at Arg 17 and Arg 26 in vitro and cooperates synergistically with p 160 type coactivators ( e . g . , GRIP 1 , SRC 1 , ACTR ) and coactivators with histone acetyltransferase activity ( e . g . , p 300 , CBP ) to enhance gene activation by steroid and nuclear hormone receptors ( NR ) in transient transfection assays . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Transcriptional activity is mediated through the SRC 1 interacting domain of CBP / p300 . ^^^ The 95 amino acid CR 2 region ( amino acids 2055 2150 ) is located adjacent to the C / H3 domain and corresponds precisely with the minimal steroid receptor coactivator 1 ( SRC 1 ) interacting domain of CBP ( also called IBiD ) . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Two nuclear receptor coactivators , steroid receptor coactivator 1 ( SRC 1 ) and cAMP response element binding protein binding protein ( CBP ) , have been shown to act in concert to enhance ER activity in vitro . ^^^ Reduction of SRC 1 and CBP protein in brain disrupted ER mediated activation of the behaviorally relevant progestin receptor gene . ^^^ Furthermore , we found that SRC 1 and CBP function in brain to modulate the expression of hormone dependent female sexual behavior . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
We now report that PIMT strongly interacts with transcriptional coactivators , CBP , p 300 , and PBP but not with SRC 1 and PGC 1alpha under in vitro and in vivo conditions . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Furthermore , not only AR but also the glucocorticoid receptor YFP , ER alpha GFP , and YFP tagged SRC 1 , TIF 2 , and CBP were found to be accumulated in identical spots in the presence of ligand . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The hypoxia inducible factor ( HIF ) 1alpha and the HIF like factor ( HLF ) transcription factors are regulated at multiple levels including protein stabilization , nuclear import , and activation of transactivation , resulting in recruitment of coactivators such as the cAMP response element binding protein ( CREB ) binding protein ( CBP ) / p300 and SRC 1 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The glucocorticoid receptor ( GR ) interacts with several coactivators , including steroid receptor coactivator 1 ( SRC 1 ) family and CREB binding protein ( CBP ) . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
In the context of full length HIF 1 alpha , mutation of the leucine residues conferred conformational changes to the protein and significantly reduced the transactivation function as well as functional interaction with the transcriptional coactivators CBP and SRC 1 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
We have explored the interaction of several known ligands and the nuclear receptor ( peroxisome proliferator activated receptor alpha , PPARalpha ) using scintillation proximity assay ( SPA ) and the interaction of LXXLL containing peptides derived from three coactivators ( SRC 1 , CBP and PGC 1 ) with PPARalpha in the presence of PPARalpha agonist ligands using fluorescence resonance energy transfer ( FRET ) . ^^^ Similarly , for all ligands tested , the rank order of EC ( 50 ) for peptide recruitment was CBP < PGC 1 < SRC 1 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The IL 8 promoter is regulated by NF kappaB / p65 in response to tumor necrosis factor alpha and requires the cooperation of the coactivators CBP / p300 and steroid receptor coactivator 1 ( SRC 1 ) and the p300 / CBP associated factor ( P / CAF ) for optimal activation . ^^^ This inhibition appears to result from the ability of HPV 16 E 6 to compete with NF kappaB / p65 and SRC 1 for binding to the N terminus and C terminus of CBP , respectively . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
PRIC complex includes known coactivators or coactivator binding proteins ( CBP , SRC 1 , PBP , PRIP , PIMT , TRAP 100 , SUR 2 , and PGC 1 ) , other proteins that have not previously been described in association with transcription complexes ( CHD 5 , TOG , and MORF ) , and a few novel polypeptides designated PRIC 300 , 285 , 215 , 177 , and 145 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The complex contains at least one of three p 160 coactivators ( SRC 1 , GRIP1 / TIF2 , or pCIP / RAC3 / ACTR / AIB1 / TRAM1 ) , a histone acetyltransferase such as CBP or p 300 , and the histone methyltransferase CARM 1 ( coactivator associated arginine methyltransferase 1 ) . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Further , 4EM mediated transcription in ER alpha , like estrogen , was enhanced in the presence of coactivators , steroid receptor coactivator 1 ( SRC 1 ) , CREB binding proteins ( CBP ) , and E 6 associated protein ( E 6 AP ) . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Upon ligand treatment , progesterone receptor ( PR ) interacted preferentially with SRC 1 , which recruited CBP and significantly enhanced acetylation at K 5 of histone H 4 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
We also show that the ligand dependent activities of ERalpha and progesterone receptor ( PR ) in yeast cells were strongly enhanced by the human p 160 protein steroid receptor coactivator ( SRC 1 ) , but not by CREB Binding Protein ( CBP ) or the p300 / CBP associated factor ( P / CAF ) . ^^^ Thus SRC 1 sequences involved in recruitment of CBP / p300 and Co Activator Associated Arginine Methyltransferase ( CARM 1 ) in mammalian cells are not essential for its function in yeast , suggesting that SRC 1 operates via distinct mechanisms in yeast and mammalian cells . . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
In the process of retinoic acid ( RA ) signaling , retinoic acid receptor interacts with a coactivator complex composed of various transcription cofactors such as CREB binding protein ( CBP ) / p300 and p 160 family member proteins represented by steroid receptor coactivator 1 ( SRC 1 ) / NCoA1 and p300 / CBP cointegrator protein ( p / CIP ) / ACTR . ^^^ The immunoprecipitates obtained with anti CBP antibody exhibited a histone acetyl transferase ( HAT ) activity 2 fold higher than that obtained with the control antibody , whereas the HAT activity of the immunoprecipitates with anti SRC 1 and anti p / CIP , which were used as comparisons , were only a little increased . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Reciprocal inhibition between Erg and ERalpha was not alleviated by overexpressing CBP , SRC 1 or RIP 140 , three nuclear coactivator proteins . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
We found that co expression of PPAR delta , retinoid 10 receptor ( RXR ) alpha , and coactivators such as CBP and SRC 1 enhanced basal and agonist dependent activation of PPAR responsive element ( PPRE ) driven transcription by PPAR delta , rendering a PPRE driven reporter assay reliable and sensitive . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The decrease in expression of RXRalpha , beta , and gamma , PPARalpha and delta , and TRalpha and beta , and of the coactivators CBP / p300 , SRC 1 , SRC 3 , TRAP 220 , and PGC 1 and the genes they regulate , induced by LPS in the heart , could account for the decreased expression of key proteins required for fatty acid oxidation and thereby play an important role in cardiac contractility . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The p 160 coactivators , steroid receptor coactivator 1 ( SRC 1 ) , transcriptional intermediary factor 2 ( TIF 2 ) and receptor associated coactivator 3 ( RAC 3 ) , as well as the coactivator / integrator CBP , mediate estrogen receptor alpha ( ERalpha ) dependent gene expression . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : The expression of 16 AR coactivators and corepressors ( SRC 1 , beta catenin , TIF 2 , PIAS 1 , PIASx , ARIP 4 , BRCA 1 , AIB 1 , AIB 3 , CBP , STAT 1 , NCoR 1 , AES , cyclin D 1 , p 300 , and ARA 24 ) was measured in prostate cancer cell lines , xenografts , and clinical prostate tumor specimens by using real time quantitative reverse transcription PCR . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
One important coactivator complex includes a p 160 coactivator ( e . g . , GRIP 1 , SRC 1 , or ACTR ) that binds directly to activated NR , the histone acetyltransferase p 300 or CBP , and the arginine specific histone methyltransferase CARM 1 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
SRC 1 then potentiates receptor activity via recruitment of CBP / p300 , a histone acetyltranferase . ^^^ This is important in the context of prostate cancer as SRC 1 and other coactivators including CBP are coexpressed with AR in the luminal epithelial cells of the prostate , where over 90 % of prostate tumours arise . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Chromatin immunoprecipitation assays revealed that when H4IIE cells were treated with Dex / RA , ligand activated retinoic acid receptors ( retinoic acid receptor / retinoid 10 receptor ) and glucocorticoid receptors are recruited to this gene promoter , as are the transcription coregulators p 300 , CREB binding protein , p / CIP , and SRC 1 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Treatment of cultured human uterine smooth muscle cells ( UtSMC ) with TNF alpha significantly reduced mRNA for the coactivators , SRC 1 ( 42 % , P < 0 . 01 ) and 2 ( 47 % , P < 0 . 03 ) , and diminished the respective protein levels , but did not significantly alter the mRNAs encoding SRC 3 , CBP and the corepressors , NCoR and SMRT ; or progesterone receptor protein levels . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
TTF 1 is acetylated by nuclear receptor coactivators including the activator of the thyroid and retinoic acid receptor , CREB binding protein , and steroid receptor coactivator 1 ( SRC 1 ) in cell transfection and immunoprecipitation studies . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
CHO K 1 cells transfected with ERalpha or ERbeta show ERE sequence dependent differences in the functional interaction of ERalpha and ERbeta with coactivators steroid receptor coactivator 1 ( SRC 1 ) , SRC 2 ( glucocorticoid receptor interacting protein 1 ( GRIP 1 ) ) , SRC 3 amplified in breast cancer 1 ( AIB 1 ) and ACTR , cyclic AMP binding protein ( CBP ) , and steroid receptor RNA activator ( SRA ) , corepressors nuclear receptor co repressor ( NCoR ) and silencing mediator for retinoid and thyroid hormone receptors ( SMRT ) , and secondary coactivators coactivator associated arginine methyltransferase 1 ( CARM 1 ) and protein arginine methyltransferase 1 ( PRMT 1 ) . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The present study used immunocytochemistry to identify a number of nuclear receptor coactivators that are expressed by adult lumbar motoneurons : SRC 1 , SRC 2 , CBP , p 300 , and cJUN . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Biochemical assays showed that depletion of CBP from cell extracts abrogated interaction between SRC 1 and HIF 1alpha . ^^^ Thus , in contrast to the current model for the assembly of complexes between nuclear hormone receptors and coactivators , the present data suggest that it is CBP that recruits SRC 1 to HIF 1alpha in hypoxic cells . ^^^ In conclusion , CBP plays an important role as a mediator of HIF 1alpha / Arnt / CBP / SRC 1 complex formation , coordinating the temporally and hierarchically regulated intranuclear traffic of HIF 1alpha and associated cofactors in signal transduction in hypoxic cells . . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
RESULTS : 1 , 25 ( OH ) 2D3 induces rapid association of the VDR and RXR with both the Cyp 24 and the Opn gene promoters in both MC3T3 E 1 osteoblasts and MOBs , interactions that are both rapid and cyclic in nature . 1 , 25 ( OH ) 2D3 treatment also induces rapid recruitment of co regulators such as SRC 1 , 2 , and 3 , CBP , and p 300 to both promoters , recruitment that leads to acetylation of histone 4 on Cyp 24 but not the Opn . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The staphylococcal nuclease like ( SN ) domains of p 100 directly interacted with amino acids 1099 1758 of CBP , while p 100 did not associate with SRC 1 , another coactivator of STAT 6 . p 100 was found to recruit histone acetyltransferase ( HAT ) activity to STAT 6 in vivo . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Although PR is recruited to the MMTV promoter equivalently in the G 1 and S phases , recruitment of SRC 1 , SRC 3 , and , consequently , CBP is reduced in G 1 phase despite comparable expression levels of SRC 1 and SRC 3 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
We additionally analyzed the participation of the coactivators SRC 1 and cAMP response element binding protein ( CREB ) binding protein ( CBP ) in FSH evoked estrogen receptor ( ER ) dependent transactivation ; we found that CBP but not SRC 1 potentiated FSH induced transcriptional activation of both ER sensitive reporters , being this effect stronger on the ERE VitA 2 TK CAT than on the 3X ERE TAT Luc reporter . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Coactivators SRC 1 , TIF 2 , RAC 3 , p 300 , CBP , Tip 60 , and gelsolin are highly expressed in endocrine therapy resistant prostate cancer . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Furthermore , EID 3 directly binds to and blocks the SRC 1 interacting domain of CBP , which has been implicated to act as the interaction surface for nuclear receptor co activators . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The amount of CBP ( CREB binding protein ) and SRC 1 ( steroid receptor coactivator 1 ) recruited by FK 614 was less than that induced by rosiglitazone and pioglitazone , but FK 614 caused similar PGC 1alpha ( PPARgamma coactivator 1alpha ) recruitment as these compounds . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Moreover , re ChIP assays confirmed the functionality of the three 1alpha , 25 ( OH ) 2D3 reponsive promoter regions by monitoring simultaneous occupancy of VDR with the co activator proteins CBP , SRC 1 and TRAP 220 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Ligand induced transcription by nuclear receptors involves the recruitment of p 160 coactivators such as steroid receptor coactivator 1 ( SRC 1 ) , in complex with histone acetyltransferases such as CREB binding protein ( CBP ) and p 300 . ^^^ Here we describe the solution structure of a complex formed by the SRC 1 interaction domain ( SID ) of CBP and the activation domain ( AD 1 ) of SRC 1 , both of which contain four helical regions ( Calpha 1 , Calpha 2 , Calpha 3 , and Calpha 3 ' in CBP and Salpha 1 , Salpha 2 ' , Salpha 2 , and Salpha 3 in SRC 1 ) . ^^^ In contrast to the structure of the AD 1 domain of the related p 160 protein ACTR in complex with CBP SID , the sequences forming Salpha 2 ' and Salpha 2 in SRC 1 AD1 are not involved in the interface between the two domains but rather serve to position Salpha 3 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Nuclear receptor coactivators , including Steroid Receptor Coactivator 1 ( SRC 1 ) and CREB Binding Protein ( CBP ) , dramatically enhance ligand dependent steroid receptor transcriptional activity in vitro . ^^^ Previously , our lab has shown that SRC 1 and CBP modulate estrogen receptor ( ER ) mediated induction of progestin receptor ( PR ) gene expression in the ventromedial nucleus of the hypothalamus ( VMN ) and hormone dependent sexual receptivity in female rats . ^^^ In the present experiments , the function of SRC 1 and CBP in distinct ER ( Exp . 1 ) and PR ( Exp . 2 ) dependent aspects of female sexual behavior was investigated . ^^^ In Exp . 1 , infusion of antisense oligodeoxynucleotides to SRC 1 and CBP mRNA into the VMN decreased lordosis intensity in rats treated with E alone , suggesting that these coactivators modulate ER mediated female sexual behavior . ^^^ In Exp . 2 , antisense to SRC 1 and CBP mRNA around the time of P administration reduced PR dependent ear wiggling and hopping and darting . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
N CoR impaired the DHT induced N C interaction of AR , and the impaired interaction was dose dependently recovered by coexpression of SRC 1 and CBP . ^^^ Coexpression of SRC 1 or CBP released YFP N CoR or endogenous N CoR from incomplete foci and simultaneously recovered complete foci of AR green fluorescent protein . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
CAS was found to bind the SRC 1 interaction domain ( SID ) of CBP via a leucine rich motif in the N terminus of the protein , that is conserved in other SID binding proteins . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Coactivators , such as steroid receptor coactivator 1 ( SRC 1A ) and CREB ( cAMP response element binding protein ) binding protein ( CBP ) , are required for efficient steroid receptor transactivation . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The helix 3 and helix 12 mutations strikingly reduced the ability of VDR to interact with the coactivators steroid receptor coactivator 1 , ACTR , and the CREB binding protein . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Our studies also demonstrate that Tip 60 co immunoprecipitates with the full length AR in vitro and that , in our system , Tip 60 enhances transactivation to levels observed with the coactivators steroid receptor coactivator 1 , p 300 , and CREB binding protein . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Differential recruitment of the coactivator proteins CREB binding protein and steroid receptor coactivator 1 to peroxisome proliferator activated receptor gamma / 9 cis retinoic acid receptor heterodimers by ligands present in oxidized low density lipoprotein . ^^^ Interestingly , the effect of the lipoxygenase products 13 ( S ) HODE and 15 ( S ) HETE as well as of the drug rosiglitazone were preferentially enhanced by the coactivator CREB binding protein , whereas the effect of the cyclooxygenase product 15 deoxy Delta ( 12 , 14 ) prostaglandin J ( 2 ) was preferentially enhanced by steroid receptor coactivator 1 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Basal and induced activities were similarly lowered by DAX 1 , an SF 1 suppressor , and raised by steroid receptor coactivator 1 , an SF 1 coactivator . cAMP response element binding protein ( CREB ) binding protein ( CBP ) that interacts preferentially with the phosphorylated CREB increased the cAMP induced FUER . 10T1 / 2 cells and human embryonic kidney ( HEK ) 293 cells do not express SF 1 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Multiple coactivators , including p 300 , steroid receptor coactivator 1 , and p300 / cAMP response element binding protein ( CREB ) binding protein ( CBP ) associated factor localize differentially to the E selectin promoter . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
The functional synergy of the p 160 coactivators [ steroid receptor coactivator 1 , glucocorticoid receptor interacting protein ( GRIP 1 ) , or the activator for thyroid hormone and retinoid receptors ] , the histone acetyltransferases cAMP response element binding protein binding protein ( CBP ) and p 300 and the histone methyltransferase coactivator associated arginine methyltransferase ( CARM 1 ) depends on the methyltransferase activity of CARM 1 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
We show that , although the CBP / p300 binding domain of steroid receptor coactivator 1 is crucial for GR transactivation , neither CBP nor p 300 enhanced GR transcriptional activation , as shown by overexpression and small interfering RNA ( siRNA ) knocking down experiments . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
T 3 treatment increased the acetylation of histones , decreased the recruitment of nuclear receptor corepressor and increased the recruitment of steroid receptor coactivator 1 , CREB binding protein , and the thyroid hormone associated protein / mediator complex at the malic enzyme T3RU . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Chromatin immunoprecipitation demonstrated CARM 1 recruitment in vivo to the promoters of NF kappaB p 65 regulated genes along with CBP and steroid receptor coactivator 1 . ^^^
Interacting proteins: Q15788 and Q92793	Pubmed	SVM Score :0.0
Using chromatin immunoprecipitation , we observed that when type 2 cells were cultured in 20 % O ( 2 ) , cAMP and IL 1 stimulated the recruitment of TTF 1 , p 65 , CBP , and steroid receptor coactivator 1 to the TBE region of the SP A promoter and increased local acetylation of histone H 3 ; these effects were prevented by hypoxia . ^^^