| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| ASC 2 also interacted with other nuclear receptors , including retinoic acid receptor , thyroid hormone receptor , estrogen receptor alpha , and glucocorticoid receptor , basal factors TFIIA and TBP , and transcription integrators CBP / p300 and SRC 1 . ^^^ In transient cotransfections , ASC 2 , either alone or in conjunction with CBP / p300 and SRC 1 , stimulated ligand dependent transactivation by wild type nuclear receptors but not mutant receptors lacking the AF 2 domain . ^^^ |
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| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| ASC 2 was recently discovered as a cancer amplified transcription coactivator molecule of nuclear receptors , which interacts with multifunctional transcription integrators steroid receptor coactivator 1 ( SRC 1 ) and CREB binding protein ( CBP ) / p300 . ^^^ In cotransfection of mammalian cells , ASC 2 potentiated transactivations by SRF , AP 1 , and NFkappaB in a dose dependent manner , either alone or in conjunction with SRC 1 and p 300 . ^^^ |
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| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| However , the action of GT 198 was distinguishable from that of the ligand binding domain interacting nuclear receptor coactivators , such as TRBP , CBP , and SRC 1 , with respect to basal activation and hormone sensitivity . ^^^ |
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| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| Although PRMT 2 was found to interact with two other coactivators , the steroid receptor coactivator 1 ( SRC 1 ) and the peroxisome proliferator activated receptor interacting protein ( PRIP ) , no synergistic enhancement of ERalpha transcriptional activity was observed when PRMT 2 was coexpressed with either PRIP or SRC 1 . ^^^ |
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| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| PRIC complex includes known coactivators or coactivator binding proteins ( CBP , SRC 1 , PBP , PRIP , PIMT , TRAP 100 , SUR 2 , and PGC 1 ) , other proteins that have not previously been described in association with transcription complexes ( CHD 5 , TOG , and MORF ) , and a few novel polypeptides designated PRIC 300 , 285 , 215 , 177 , and 145 . ^^^ |
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| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| In cotransfection , DN 2 , an ASC 2 fragment encompassing this motif , exerts a potent dominant negative effect on transactivation by LXRs , which is rescued by ectopic coexpression of the full length ASC 2 but not by other LXXLL type coactivators , such as SRC 1 and TRAP 220 . ^^^ |
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| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : The expression of 16 AR coactivators and corepressors ( SRC 1 , beta catenin , TIF 2 , PIAS 1 , PIASx , ARIP 4 , BRCA 1 , AIB 1 , AIB 3 , CBP , STAT 1 , NCoR 1 , AES , cyclin D 1 , p 300 , and ARA 24 ) was measured in prostate cancer cell lines , xenografts , and clinical prostate tumor specimens by using real time quantitative reverse transcription PCR . ^^^ |
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| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| Using this homogenous method several coregulator NR boxes capable of associating with thyroid receptor at physiologically relevant concentrations were identified including ones found in traditional coactivating proteins such as SRC 1 , SRC 2 , TRAP 220 , TRBP , p 300 , and ARA 70 ; and those in coregulators known to repress gene activation including RIP 140 and DAX 1 . ^^^ |
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| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| Both ERalpha and ERbeta exhibited strong preferences for coactivator peptides corresponding to steroid receptor coactivator 1 and PPARgamma coactivor 1 vs . peroxisome proliferator activated receptor interacting protein and cAMP response element binding protein binding protein . 17beta Estradiol acted as a nonselective agonist for ERalpha and ERbeta . ^^^ |
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| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| FK 614 behaves as a partial agonist in inducing the interaction of PPARgamma with both transcriptional coactivators , cAMP response element binding protein binding protein and steroid receptor coactivator 1 , but as a full agonist with both PPAR binding protein and PPAR interacting protein , which are required for PPARgamma mediated adipogenesis . ^^^ |
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| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and Q14686 |
Pubmed |
SVM Score :0.0 |
| NA |
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