| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :0.98471814 |
| We conclude that SF 1 harbors at least two activation domains within its carboxy terminus and that both are required for its transcriptional activation function and for direct interaction with SRC 1 . 0.98471814^^^ |
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| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :1.2512584 |
| In mammalian two hybrid assays , fusion of the VP 16 activation domain to the interaction domain of SRC 1 confirmed the interaction between SRC 1 and GAL 4 SF 1 and demonstrated that the AF 2 domain is required for interaction with SRC 1 . 1.2512584^^^ Several lines of evidence demonstrated that SF 1 interacts with steroid receptor coactivator 1 ( SRC 1 ) . 0.63630184^^^ |
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| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Transcriptional repression by COUP TFI is mediated by corepressors , N CoR ( nuclear receptor corepressor ) and SMRT ( silencing mediator for retinoid and thyroid hormone receptor ) , whereas transcriptional activation by SF 1 is mediated by coactivator SRC 1 ( steroid receptor coactivator 1 ) . ^^^ We therefore examined the expression of COUP TFI , SF 1 , SRC 1 , N CoR , and SMRT in a variety of adrenocortical adenomas and compared the results with CYP 17 mRNA levels . ^^^ |
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| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Finally , we demonstrate that the coactivators CBP and SRC 1 are limiting with respect to cAMP induced CRS 2 dependent transcription in Y 1 adrenocortical tumor cells , suggesting that part of the action of cAMP may be to influence the interaction of SF 1 with other cofactors via the AF 2 domain . . ^^^ |
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| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :0.0 |
| In addition , the levels of SF 1 and other cofactors including WT 1 , CBP / p300 , and steroid receptor coactivator 1 did not differ appreciably between parent and mutant cells . ^^^ |
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| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Coactivators with histone acetyltransferase activity such as cAMP response element binding protein binding protein and steroid receptor coactivator 1 interact and increase SF 1 mediated transcriptional activity . ^^^ |
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| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Steroid receptor coactivator 1 and transcription intermediary factor 2 ( TIF 2 ) belong to the p 160 coactivator family that mediates transcriptional activation by several nuclear receptors , including SF 1 . ^^^ |
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| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Basal and induced activities were similarly lowered by DAX 1 , an SF 1 suppressor , and raised by steroid receptor coactivator 1 , an SF 1 coactivator . cAMP response element binding protein ( CREB ) binding protein ( CBP ) that interacts preferentially with the phosphorylated CREB increased the cAMP induced FUER . 10T1 / 2 cells and human embryonic kidney ( HEK ) 293 cells do not express SF 1 . ^^^ |
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| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Forskolin induced recruitment of SRC 1 to the SF 1 response element and induced SRC 1 SF 1 interactions , whereas AII increased recruitment of SRC 1 to the nur 77 response element and induced SRC 1 nur 77 interactions . ^^^ |
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| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :0.0 |
| In this study we assessed roles of steroid receptor coactivator 1 ( SRC 1 ) in hypothalamic pituitary adrenal ( HPA ) axis function using SRC 1 deficient ( SRC 1 / ) mice in the absence or presence of SF 1 haploinsufficiency . ^^^ |
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| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Transfection assays using an inhibin alpha subunit promoter reporter in GRMO 2 granulosa cells show that LRH 1 and SF 1 act similarly to increase promoter activity , and that the activity of both transcription factors is augmented by the coactivators cAMP response element binding protein binding protein and steroid receptor coactivator 1 . ^^^ |
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| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13285 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|