| Interacting proteins: Q13133 and Q15788 |
Pubmed |
SVM Score :0.0 |
| A cell free assay was developed for the orphan nuclear receptor LXRalpha that measures the ligand dependent recruitment of a peptide from the steroid receptor coactivator 1 ( SRC 1 ) to the nuclear receptor . ^^^ The structural requirements for SRC 1 recruitment in the LiSA correlated with the transcriptional activity of compounds in a cell based reporter assay employing LXRalpha GAL 4 chimeric receptors . ^^^ |
|
| Interacting proteins: Q13133 and Q15788 |
Pubmed |
SVM Score :0.0 |
| YT 32 directly bound to LXRalpha and LXRbeta and induced the interaction of LXRalpha with cofactors , such as steroid receptor coactivator 1 , as effectively as the natural ligands , 22 ( R ) hydroxycholesterol and 24 ( S ) , 25 epoxycholesterol . ^^^ |
|
| Interacting proteins: Q13133 and Q15788 |
Pubmed |
SVM Score :0.0 |
| GSK 3987 recruits the steroid receptor coactivator 1 to human LXRalpha and LXRbeta with EC ( 50 ) s of 40 nM , profiles as an LXR agonist in functional assays , and activates LXR though a mechanism that is similar to first generation LXR agonists . . ^^^ |
|
| Interacting proteins: Q13133 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Desmosterol bound to purified LXRalpha and LXRbeta in vitro and supported the recruitment of steroid receptor coactivator 1 . ^^^ |
|
| Interacting proteins: Q13133 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|