| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.87373633 |
| We previously isolated and identified steroid receptor coactivator 1 ( SRC 1 ) and peroxisome proliferator activated receptor ( PPAR ) binding protein ( PBP / PPARBP ) as coactivators for PPAR , using the ligand binding domain of PPARgamma as bait in a yeast two hybrid screening . 0.87373633^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.51871743 |
| We have explored the interaction of several known ligands and the nuclear receptor ( peroxisome proliferator activated receptor alpha , PPARalpha ) using scintillation proximity assay ( SPA ) and the interaction of LXXLL containing peptides derived from three coactivators ( SRC 1 , CBP and PGC 1 ) with PPARalpha in the presence of PPARalpha agonist ligands using fluorescence resonance energy transfer ( FRET ) . 0.51871743^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| We report the 10 ray crystal structure of the ligand binding domain of PPAR alpha ( NR1C1 ) as a complex with the agonist ligand GW 409544 and a coactivator motif from the steroid receptor coactivator 1 . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| In contrast to RAR , which prevents the binding of RXR ligands and recruits the nuclear receptor corepressor N CoR , PPAR permits the binding of SRC 1 in response to both RXR and PPAR ligands . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| In an attempt to identify cofactors that could possibly influence the transcriptional activity of peroxisome proliferator activated receptors ( PPARs ) , we used a yeast two hybrid system with Gal 4 PPARgamma as bait to screen a mouse liver cDNA library and have identified steroid receptor coactivator 1 ( SRC 1 ) as a PPAR transcriptional coactivator . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| A new approach to identify ligands was developed based on the ligand dependent interaction of PPAR with the recently characterized co activator SRC 1 . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Expression of the coactivators SRC 1 and CREB binding protein , which bind to PPAR , also enhanced the responsiveness of the prolactin promoter to PPARalpha . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| STAT5b inhibition was not reversed by overexpression of the heterodimerization partner of PPAR ( retinoid 10 receptor ) or the nuclear receptor coactivators P 300 and SRC 1 , suggesting that STAT5b does not inhibit PPARalpha by competing for these limiting cellular cofactors . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Consistent with this finding , an in vitro coactivator association assay demonstrated that troglitazone bound PPAR gamma recruited the transcriptional coactivators p 300 and steroid receptor coactivator 1 less efficiently than rosiglitazone bound receptor . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Using PPAR as bait in the yeast two hybrid system , the authors recently cloned mouse steroid receptor coactivator 1 ( SRC 1 ) and PPAR binding protein ( PBP ) , and identified them as PPAR coactivators . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Coexpression of nuclear receptor corepressor suppressed , whereas steroid receptor coactivator 1 enhanced the transcriptional activity of each of the GFP PPAR isoforms , but did not discernibly alter their intracellular distributions , both in the presence and absence of PPAR ligands . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| These showed that the indomethacin , a PPAR gamma ligand , increased the binding between PPAR gamma and SRC 1 in a ligand dose dependent manner . ^^^ These results suggested that the in vitro conformational change of PPAR gamma by ligands was also induced , and increased the levels of the ligand dependent interaction with SRC 1 . ^^^ This screening system ( based on the interaction between PPAR gamma and SRC 1 ) may be a promising system in the development of drugs for metabolic disorders . . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| We found that co expression of PPAR delta , retinoid 10 receptor ( RXR ) alpha , and coactivators such as CBP and SRC 1 enhanced basal and agonist dependent activation of PPAR responsive element ( PPRE ) driven transcription by PPAR delta , rendering a PPRE driven reporter assay reliable and sensitive . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Chromatin immunoprecipitation ( ChIP ) analysis revealed that BTZD induced the binding of PPARgamma SRC 1 complex to PPAR response element ( PPRE ) in the same pattern of other PPARgamma ligand . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| FK 614 behaves as a partial agonist in inducing the interaction of PPARgamma with both transcriptional coactivators , cAMP response element binding protein binding protein and steroid receptor coactivator 1 , but as a full agonist with both PPAR binding protein and PPAR interacting protein , which are required for PPARgamma mediated adipogenesis . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| We assessed the in vivo function of SRC 1 on the PPARalpha regulated gene expression in liver by generating mice in which the SRC 1 gene was inactivated by gene targeting . ^^^ When challenged with a PPARalpha ligand , such as ciprofibrate or Wy 14 , 643 , the SRC 1 ( / ) mice displayed typical pleiotropic responses , including hepatomegaly , peroxisome proliferation in hepatocytes , and increased mRNA and protein levels of genes that are regulated by PPARalpha . ^^^ These results indicate that SRC 1 is not essential for PPARalpha mediated transcriptional activation in vivo and suggest redundancy in nuclear receptor coactivators . . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Interestingly , fatty acyl CoAs , unlike fatty acids , failed to recruit steroid receptor co activator 1 ( SRC 1 ) , on the basis of conformational changes in the LBDs of PPARalpha and PPARgamma . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that while RA does not activate PPARalpha and PPARgamma , it binds to PPARbeta / delta with nanomolar affinity , modulates the conformation of the receptor , promotes interaction with the coactivator SRC 1 , and efficiently activates PPARbeta / delta mediated transcription . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| The decrease in expression of RXRalpha , beta , and gamma , PPARalpha and delta , and TRalpha and beta , and of the coactivators CBP / p300 , SRC 1 , SRC 3 , TRAP 220 , and PGC 1 and the genes they regulate , induced by LPS in the heart , could account for the decreased expression of key proteins required for fatty acid oxidation and thereby play an important role in cardiac contractility . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Phytol induced the increase in PPARalpha dependent luciferase activity and the degree of in vitro binding of a coactivator , SRC 1 , to GST PPARalpha . ^^^ |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
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