| Interacting proteins: P41235 and Q15788 |
Pubmed |
SVM Score :0.87364902 |
| The AF 2 domain of HNF 4 is required for this interaction and for the potentiation of transcriptional activity by these coactivators . p 300 can also serve as a coactivator with HNF 4 , and it synergizes with SRC 1 to further augment the activity of HNF 4 . 0.87364902^^^ In this study , we show that SRC 1 and GRIP 1 , which act as coactivators for various nuclear receptors , associate with HNF 4 in vivo and enhance its transactivation potential . 0.74480141^^^ |
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| Interacting proteins: P41235 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Rifampicin strongly stimulated PXR and hepatocyte nuclear factor 4alpha ( HNF4alpha ) interaction , and CYP3A4 reporter activity , which was further stimulated by peroxisome proliferators activated receptorgamma co activator 1alpha ( PGC 1alpha ) and steroid receptor coactivator 1 ( SRC 1 ) but inhibited by SHP . ^^^ Chromatin immunoprecipitation assays revealed that rifampicin activated PXR recruited HNF4alpha and SRC 1 to the CYP3A4 chromatin . ^^^ On the other hand , SHP reduced PXR recruitment of HNF4alpha and SRC 1 to the CYP3A4 chromatin . ^^^ Results suggest that PXR strongly induces CYP3A4 gene transcription by interacting with HNF4alpha , SRC 1 , and PGC 1alpha . ^^^ |
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| Interacting proteins: P41235 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
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