| Interacting proteins: P35869 and Q15788 |
Pubmed |
SVM Score :1.2376882 |
| Using GFP tagged constructs , SRC 1 was shown to interact with AhR in cells . 1.2376882^^^ SRC 1 interacted weakly with AhR in the absence of TCDD and the addition of ligand further increased SRC 1 binding to AhR . 1.0842749^^^ In in vitro interaction assays , SRC 1 was found to interact with AhR but not with ARNT . 1.0000211^^^ Unlike RIP 140 , LXXLL motifs in SRC 1 were necessary for interaction with AhR in vitro and for coactivation in Hepa 1 cells . 0.60061961^^^ |
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| Interacting proteins: P35869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Furthermore , nuclear receptor coactivators p300 / CBP and steroid receptor coactivator 1 act individually as well as cooperatively to reverse the suppressive effects by NF kappaB on the AhR activated reporter gene , suggesting that these transcriptional coactivators serve as the common integrators for the two pathways , thereby mediating the cross interactions between AhR and NF kappaB . ^^^ |
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| Interacting proteins: P35869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| In this report , we demonstrate that SRC 1 , NCoA 2 , and p / CIP are capable of independently enhancing TCDD dependent induction of a luciferase reporter gene by the AHR / ARNT dimer . ^^^ We demonstrate by coimmunoprecipitation and by a reporter gene assay that SRC 1 and NCoA 2 but not p / CIP are capable of interacting with ARNT in vivo after transient transfection into mammalian cells , while AHR is capable of interacting with all three coactivators . ^^^ We confirm the interactions of ARNT and AHR with SRC 1 with immunocytochemical techniques . ^^^ SRC 1 does not require its bHLH PAS domain to interact with ARNT or AHR , but utilizes distinct domains proximal to its p300 / CBP interaction domain . ^^^ |
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| Interacting proteins: P35869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| The repressive effects of TCDD are paralleled by increased recruitment of the liganded AhR and HDAC 1 , reduced occupancy by p 300 , SRC 1 , and diminished acetylation of H 4 at the BRCA 1 promoter region flanking the XREs . ^^^ |
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| Interacting proteins: P35869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Six of the genes studied ( aryl hydrocarbon receptor nuclear transporter , aryl hydrocarbon receptor nuclear transporter 2 , Clock , endothelial PAS containing protein , hypoxia inducible factor 1alpha and steroid receptor coactivator 1 ) were expressed in the suprachiasmatic nucleus of adult and neonatal mice . ^^^ |
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| Interacting proteins: P35869 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
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