| Interacting proteins: P10589 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Transcriptional repression by COUP TFI is mediated by corepressors , N CoR ( nuclear receptor corepressor ) and SMRT ( silencing mediator for retinoid and thyroid hormone receptor ) , whereas transcriptional activation by SF 1 is mediated by coactivator SRC 1 ( steroid receptor coactivator 1 ) . ^^^ We therefore examined the expression of COUP TFI , SF 1 , SRC 1 , N CoR , and SMRT in a variety of adrenocortical adenomas and compared the results with CYP 17 mRNA levels . ^^^ |
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| Interacting proteins: P10589 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that GRIP 1 and SRC 1 potentiate the activity of COUP TFI and that COUP TFI associates with these coactivators in vivo using the same region required for transcription activation . ^^^ Finally , overexpression of GRIP 1 or SRC 1 does not convert COUP TFI from a transcriptional repressor into a transcriptional activator in HeLa cells . . ^^^ |
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