| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :1.0468917 |
| In this report , we demonstrate that RAR selective ligands have distinct quantitative activation properties which are reflected by their abilities to promote interaction of DNA bound human RXRalpha ( hRXRalpha ) hRARalpha heterodimers with the nuclear receptor coactivator ( NCoA ) SRC 1 in vitro . 1.0468917^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| In contrast to RAR , which prevents the binding of RXR ligands and recruits the nuclear receptor corepressor N CoR , PPAR permits the binding of SRC 1 in response to both RXR and PPAR ligands . ^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Several nuclear receptor coactivators ( CBP , F SRC 1 , SRC 1 , and RIP 140 ) that interact with other steroid receptors were tested as potential mediators of the N and C terminal interaction of rAR using the mammalian two hybrid system . ^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Recruitment of an LXXLL motif of SRC 1 to RAR in response to ligand displaces the RXR AF 2 domain , allowing RXR ligands to bind and promote the binding of a second LXXLL motif from the same SRC 1 molecule . ^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| RAR coactivators ACTR , SRC 1 , and transcriptional intermediary factor 2 ( TIF 2 ) stimulated human ( h ) SP B promoter activity in a dose dependent fashion in pulmonary adenocarcinoma H 441 cells . ^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that both peroxisome proliferator activated receptor binding protein ( PBP ) and steroid receptor coactivator 1 ( SRC 1 ) are required for ligand dependent transcription of transiently transfected and chromosomally integrated reporter genes by the estrogen receptor ( ER ) and retinoic acid receptor ( RAR ) . ^^^ CFP fusions to RAR or its ligand binding domain exhibited rapid ligand dependent FRET to YFP tagged nuclear receptor interaction domains of the coactivators SRC 1 and PBP . ^^^ These findings suggest that ligand dependent transcriptional activities of the RAR and ER require concurrent or sequential recruitment of SRC 1 and PBP containing coactivator complexes . . ^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| This loss of cooperativity suggested a delayed acquisition of RAR full transcriptional competence because ( 1 ) cooperativity was maintained at RAR ligand subsaturating concentrations , ( 2 ) overexpression of SRC 1 led to loss of cooperativity and even to strong repression of chromosomal templates activity , and ( 3 ) loss of cooperativity was observed when additional cis acting response elements were activated . ^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| We however previously showed that retinoids displayed very different abilities to activate retinoid inducible reporter genes , and that these differential properties were correlated to the ability of a given ligand to promote SRC 1 recruitment by DNA bound RXR : RAR heterodimers . ^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| First , corepressor SMRT [ for silencing mediator of thyroid hormone receptor ( TR ) and retinoic acid receptor ( RAR ) ] inhibits the interaction of coactivator steroid receptor coactivator 1 with liganded TR / RAR . ^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| In contrast , the strength of the overall association between the heterodimer and the full length SRC 1 NID is dictated by the combinatorial action of RAR and RXR ligands , the simultaneous presence of the two receptor agonists being required for highest binding affinity . ^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Overall , these results suggest that ASXL 1 is a novel coactivator of RAR that cooperates with SRC 1 and implicates it as a potential antitumor target of RA in RA resistant cancer cells . . ^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| SRC 1 deficient P 19 cells showed severely compromised retinoid induced responses , in agreement with the supposed role of SRC 1 as a RAR coactivator . ^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| The aim of the study was to test the hypothesis that expression of retinoid receptors ( RARalpha , RARbeta , RARgamma ) , rexinoid receptors ( RXRalpha , RXRbeta ) , thyroid hormone receptors ( TRalpha , TRbeta ) , estrogen receptors ( ERalpha , ERbeta ) , nuclear receptor coregulators ( N CoR , SRC 1 , SMRT ) , and in addition type 1 iodothyronine 5 ' deiodinase ( 5 ' DI ) , EGFR and erb B2 / neu would be different in mammary postlactating tissue in comparison with that of nonlactating mammary gland . ^^^ Using RT PCR , we have shown that expression of RARalpha , RXRalpha , TRalpha , ERalpha , ERbeta , N CoR , SRC 1 , SMRT and EGFR in rat was significantly increased in postlactating mammary gland when compared to that of nonlactating mammary tissue . ^^^ |
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| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10276 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
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