| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.73970173 |
| We have shown that SRC 1 unexpectedly interacts with GR via its two nuclear receptor binding domains , thus providing a novel mechanism of GR signaling within the nervous system . . 0.73970173^^^ Because SRC 1 is the omnipresent coactivator of GR , we further investigated the interactions between GR and this coactivator in Schwann cells by reporter assays and immunocytochemistry experiments with deleted forms of SRC 1 . 0.60749078^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.66911491 |
| A point mutation of the AF 2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1 . 0.66911491^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.52721593 |
| We report that p 300 and steroid receptor coactivator 1 interact transiently with the glucocorticoid receptor and that the acetyltransferase activity of p 300 makes an important contribution to glucocorticoid receptor mediated transcription . 0.52721593^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| SRC 1 can relieve the NF kappaB mediated repression of GR activity . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Full length TRAM 1 ( aa 1 1424 ) and the partial ( aa 459 1424 ) were AR and GR coactivators as was SRC 1 . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Coexpression of MTI 2 with the coactivator SRC 1 or p 300 further enhances GR dependent transcription . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Moreover we observed that NCoA 1 is involved in the synergistic action of the glucocorticoid receptor and STAT5a on the beta casein promoter . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Nuclear receptor binding sites of coactivators glucocorticoid receptor interacting protein 1 ( GRIP 1 ) and steroid receptor coactivator 1 ( SRC 1 ) : multiple motifs with different binding specificities . ^^^ The activity of the AF 2 transcriptional activation function of nuclear receptors ( NR ) is mediated by the partially homologous transcriptional coactivators , glucocorticoid receptor interacting protein 1 ( GRIP 1 ) / transcriptional intermediary factor 2 ( TIF 2 ) and steroid receptor coactivator 1 ( SRC 1 ) . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| However , other target proteins ( e . g . , RIP 140 , and SRC 1 ) , which interact with the GR C terminus , did not show significant interactions with the tau 1 core under our conditions . . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| As anticipated from its location , the L454S mutant interacts weakly with CoAs , such as SRC 1 and glucocorticoid receptor interacting protein 1 ( GRIP 1 ) in gel mobility shift assays and in mammalian two hybrid assays , even in the presence of the maximal dose of T 3 . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| We also demonstrated functional differentiation between CBP and other coactivators , including SRC 1 and the CBP related protein p 300 , both of which influenced GR signaling in a positive fashion . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| ASC 2 also interacted with other nuclear receptors , including retinoic acid receptor , thyroid hormone receptor , estrogen receptor alpha , and glucocorticoid receptor , basal factors TFIIA and TBP , and transcription integrators CBP / p300 and SRC 1 . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Candidate factors have been identified by the observation that changes in glucocorticoid induction parameters in CV 1 cells could be reproduced by varying the cellular levels of coactivators [ transcriptional intermediary factor 2 ( TIF 2 ) , steroid receptor coactivator 1 ( SRC 1 ) , and amplified in breast cancer 1 ( AIB 1 ) ] , comodulator [ CREB binding protein ( CBP ) ] , or corepressor [ silencing mediator for retinoid and thyroid hormone receptors ( SMRT ) ] without concomitant increases in GR . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| In addition , we show that members of the p 160 family of nuclear receptor coactivators , ACTR ( activator of thyroid and retinoic acid receptors ) , GRIP 1 ( glucocorticoid receptor interacting protein 1 ) , and SRC 1 ( steroid receptor coactivator 1 ) , potentiate the transcriptional activity by hERR 1 and hERR 2 in mammalian cells , and that both orphan receptors bind the coactivators in a ligand independent manner . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| In a yeast transactivation assay RIP 140 and SRC 1 , a member of the steroid receptor coactivator family of proteins , both enhanced the transactivation activity of a GR protein ( GRA 1 ) in which the potent N terminal tau 1 transactivation domain has been deleted . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| We have used yeast genetics and in vitro protein protein interaction experiments to explore the possibility that GCN 5 ( general control nonrepressed protein 5 ) and several other ADA ( alteration / deficiency in activation ) adaptor proteins of the multimeric SAGA complex can regulate T3 / GRIP1 ( glucocorticoid receptor interacting protein 1 ) and SRC 1 ( steroid receptor coactivator 1 ) coactivator dependent activation of transcription by the human T 3 receptor beta 1 ( hTRbeta 1 ) . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Furthermore , using cotransfection and antisense technology we have found that , unlike SRC 1 and GRIP 1 , which are not involved in the GR complex that suppresses keratin genes , histone acetyltransferase and CBP are . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Members of the p 160 coactivator family ( steroid receptor coactivator 1 ( SRC 1 ) , glucocorticoid receptor interacting protein 1 ( GRIP 1 ) , and activator of thyroid and retinoic acid receptors ( ACTR ) ) mediate transcriptional activation by nuclear receptors . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , glucocorticoid receptor is still required when SRC 1 is recruited directly to the GAL 4 site , suggesting a role for the receptor in activating SRC 1 in the context of the GRU . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Unlike the steroid hormone receptor coactivator 1 ( SRC 1 ) , beta catenin showed a strong interaction with AR but not with other steroid hormone receptors such as estrogen receptor alpha , progesterone receptor beta , and glucocorticoid receptor . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| The glucocorticoid receptor ( GR ) interacts with several coactivators , including steroid receptor coactivator 1 ( SRC 1 ) family and CREB binding protein ( CBP ) . ^^^ In this study , we have shown that one of the coactivators interacting with GR , SRC 1 , is downregulated by dexamethasone ( DEX ) both in vivo and in vitro . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| In contrast , at the osteocalcin gene GRE , where GR represses transcription by binding to a DNA site overlapping the TATA box , both GRIP 1 and SRC 1 corepressed , and the GRIP 1 specific repression domain was dispensable . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| RU 486 did not direct SRC 1 recruitment to any of the GR constructs , and dexamethasone did not allow NCoR N 1 recruitment . ^^^ As both SRC 1 and NCoR are predicted to recognize a common hydrophobic cleft in the GR , it seems that changes favorable to one interaction are detrimental to the other , thus identifying a molecular switch . . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Loss of function experiments further support the predicted roles of SRC 1 and SRC 2 in , respectively , PR and GR mediated transcription on the MMTV promoter . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Using the bioluminescence resonance energy transfer assay , we found that RU 486 efficiently recruited NCoR to the GR , unlike dexamethasone , which recruited SRC 1 . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| CHO K 1 cells transfected with ERalpha or ERbeta show ERE sequence dependent differences in the functional interaction of ERalpha and ERbeta with coactivators steroid receptor coactivator 1 ( SRC 1 ) , SRC 2 ( glucocorticoid receptor interacting protein 1 ( GRIP 1 ) ) , SRC 3 amplified in breast cancer 1 ( AIB 1 ) and ACTR , cyclic AMP binding protein ( CBP ) , and steroid receptor RNA activator ( SRA ) , corepressors nuclear receptor co repressor ( NCoR ) and silencing mediator for retinoid and thyroid hormone receptors ( SMRT ) , and secondary coactivators coactivator associated arginine methyltransferase 1 ( CARM 1 ) and protein arginine methyltransferase 1 ( PRMT 1 ) . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| We identified defective steroid receptor co activator 1 ( SRC 1 ) recruitment to the GR AF 2 in COR L 103 cells , although SRC 1 was successfully recruited to the steroid 10 receptor with rifampicin , suggesting a defect in the GR . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Although RA receptor gamma and glucocorticoid receptor bind to the same response element repressing transcription of keratins K6 / K16 , RA receptor interacts with the components of the EGF enhanceosome ( co activators : glucocorticoid receptor interactive protein 1 ( GRIP 1 ) / steroid receptors coactivator 1 ( SRC 1 ) ) without breaking it . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| They exert their effects on neuronal and glial cells by means of their cognate receptor , the glucocorticoid receptor ( GR ) , which recruits the p 160 coactivator family members SRC 1 ( steroid receptor coactivator 1 ) , SRC 2 , and SRC 3 after hormone binding . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| We report here that overexpression of steroid receptor coactivator 1 ( SRC 1 ) and GR interacting protein 1 ( GRIP 1 ) enhanced repression by liganded GR , and by a GR mutant defective in repression . ^^^ Surprisingly , SRC 1 and GRIP 1 also enhanced TGFbeta induced activation from the TGFbeta responsive sequence of the PAI 1 gene by a GR independent mechanism . ^^^ Thus , the GR coactivators , SRC 1 and GRIP 1 , act as both corepressors of the glucocorticoid repression of PAI 1 gene transcription , and coactivators of TGFbeta induced activation of the PAI 1 promoter . . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Here we report that the C terminal region of p 160 coactivators glucocorticoid receptor interacting protein 1 ( GRIP 1 ) , steroid receptor coactivator 1 ( SRC 1a ) , and SRC 1e binds the N terminal AF 1 activation function of the androgen receptor ( AR ) , and p 160 coactivators can thereby enhance transcriptional activation by AR . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| In addition , the regulation of genes encoding the glucocorticoid receptor and steroid receptor coactivator 1 suggested autoregulation of a GC mediated signaling pathway . . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| Transactivation by GR is potentiated by accessory coactivators such as steroid receptor coactivator 1 and peroxisome proliferator activated receptor gamma coactivator 1 , whereas the role of these proteins in transrepression is unclear . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| The p 160 coactivators , steroid receptor coactivator 1 , glucocorticoid receptor interacting protein 1 ( GRIP 1 ) and the activator of thyroid and retinoic acid receptor , have two activation domains , AD 1 and AD 2 , which transmit the activation signal from the DNA bound nuclear receptor to the chromatin and / or transcription machinery . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| The functional synergy of the p 160 coactivators [ steroid receptor coactivator 1 , glucocorticoid receptor interacting protein ( GRIP 1 ) , or the activator for thyroid hormone and retinoid receptors ] , the histone acetyltransferases cAMP response element binding protein binding protein ( CBP ) and p 300 and the histone methyltransferase coactivator associated arginine methyltransferase ( CARM 1 ) depends on the methyltransferase activity of CARM 1 . ^^^ |
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| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| We show that , although the CBP / p300 binding domain of steroid receptor coactivator 1 is crucial for GR transactivation , neither CBP nor p 300 enhanced GR transcriptional activation , as shown by overexpression and small interfering RNA ( siRNA ) knocking down experiments . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| We found that TRbeta , several associated coactivators ( steroid receptor coactivator 1 , glucocorticoid receptor interacting protein 1 , and TR associated protein 220 ) , and RNA Pol 2 were rapidly recruited to thyroid hormone response elements as early as 15 min after T 3 addition . ^^^ |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15788 and P04150 |
Pubmed |
SVM Score :0.0 |
| NA |
|