| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.55318999 |
| Interestingly , rifampicin also increased the interaction of SXR with SMRT as well as with coactivator SRC 1 . 0.55318999^^^ On the other hand , the anti fungal agent ketoconazole decreased SXR interaction with both SRC 1 and SMRT . 0.54335353^^^ |
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| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.57493784 |
| In yeast two hybrid protein interaction assay , PXR interacted with nuclear receptor coactivator proteins , SRC 1 , RIP 140 , and SUG 1 in a ligand dependent manner . 0.57493784^^^ |
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| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.0 |
| SJW recruits steroid receptor coactivator 1 to SXR in a two hybrid assay and competes with radiolabelled ligand in binding studies , suggesting it interacts directly with the receptor LBD . ^^^ |
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| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.0 |
| BPA induced interaction of human SXR / PXR with steroid receptor coactivator 1 ( SRC 1 ) was analyzed by mammalian two hybrid assays . ^^^ In mammalian two hybrid assays , BPA recruited SRC 1 to the ligand binding domain of human SXR / PXR . ^^^ |
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| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.0 |
| We present the 2 . 0A crystal structure of the human PXR ligand binding domain ( LBD ) in complex with the cholesterol lowering compound SR 12813 and a 25 amino acid residue fragment of the human steroid receptor coactivator 1 ( SRC 1 ) containing one LXXLL motif . ^^^ The SRC 1 peptide forms two distinct helices and binds adjacent to the ligand dependent transactivation AF 2 helix on the surface of PXR . ^^^ Thermal denaturation studies reveal that the SR 12813 ligand and SRC 1 coactivator peptide each stabilize the LBD of PXR , and that together they exert an additive effect on the stability of the receptor . ^^^ |
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| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Treatment with PMA also abolished the ligand dependent interaction between PXR and the steroid receptor co activator 1 protein ( SRC 1 ) . ^^^ |
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| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.0 |
| Rifampicin strongly stimulated PXR and hepatocyte nuclear factor 4alpha ( HNF4alpha ) interaction , and CYP3A4 reporter activity , which was further stimulated by peroxisome proliferators activated receptorgamma co activator 1alpha ( PGC 1alpha ) and steroid receptor coactivator 1 ( SRC 1 ) but inhibited by SHP . ^^^ Chromatin immunoprecipitation assays revealed that rifampicin activated PXR recruited HNF4alpha and SRC 1 to the CYP3A4 chromatin . ^^^ On the other hand , SHP reduced PXR recruitment of HNF4alpha and SRC 1 to the CYP3A4 chromatin . ^^^ Results suggest that PXR strongly induces CYP3A4 gene transcription by interacting with HNF4alpha , SRC 1 , and PGC 1alpha . ^^^ |
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| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.0 |
| The lin 5 and gpr 1 / gpr 2 genes appear to act downstream of the par polarity genes in the one and two cell stages and downstream of the tyrosine kinase related genes mes 1 and src 1 at the four cell stage . ^^^ |
|
| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75469 and Q15788 |
Pubmed |
SVM Score :0.0 |
| NA |
|