| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The result indicated that the activity of both p38alpha and p38b MAPKs in normal adult mouse brain was remarkably high , and the nuclear pool of the p 38 isoforms was primarily responsible for most of the constitutive p 38 MAPK activity in brain . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Generation and characterization of p38beta ( MAPK 11 ) gene targeted mice . p 38 mitogen activated protein kinases ( MAPKs ) are activated primarily in response to inflammatory cytokines and cellular stress , and inhibitors which target the p38alpha and p38beta MAPKs have shown potential for the treatment of inflammatory disease . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Here we show that the stress activated protein ( SAP ) kinases SAPK1gamma ( also called JNK 1 ) , SAPK2a ( also called p 38 , RK , CSBPs , Mpk 2 and Mxi 2 ) , SAPK2b ( also called p38beta ) , SAPK 3 ( also called ERK 6 and p38gamma ) and SAPK 4 phosphorylate tau at many serine / threonine prolines , as assessed by the generation of the epitopes of phosphorylation dependent anti tau antibodies . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Both enzymes phosphorylated the transcription factors ATF 2 , Elk 1 and SAP 1 at similar rates , but were far less effective than SAPK2a ( also called RK / p38 ) or SAPK2b ( also called p38beta ) in activating MAPKAP kinase 2 and MAPKAP kinase 3 . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The p 38 MAP kinase kinase MKK 6 is identified as a common activator of p 38 alpha , p 38 beta 2 , and p 38 gamma MAP kinase isoforms , while MKK 3 activates only p 38 alpha and p 38 gamma MAP kinase isoforms . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| PRAK activity was regulated by p38alpha and p38beta both in vitro and in vivo and Thr 182 was shown to be the regulatory phosphorylation site . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The pyridinyl imidazoles like SB 202190 are specific inhibitors of p38alpha and p38beta and have been widely used in investigation of the biological functions of p 38 . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| We expressed each p 38 homolog in Escherichia coli and purified the recombinant isoforms . p38alpha and C terminal Flag tagged p38beta were purified by Q Sepharose fast flow , hydroxyapatite , and Q Sepharose high performance chromatography . ^^^ Upstream activators of p 38 , constitutively active ( ca ) MKK 3 and MKK 6 , were also cloned , purified , and used to activate each p 38 isoform . p 38 alpha , gamma , and delta were phosphorylated by both MKK 6 and caMKK 3 . p38beta was phosphorylated only by MKK 6 . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Overall , p 38 delta resembles p 38 gamma , whereas p 38 beta resembles p 38 alpha . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Expression was measured at the level of mRNA by reverse transcriptase PCR and protein by Western blot analysis . p38alpha was the dominant form of p 38 in monocytes ; expression of p38delta was low and p38beta was undetected . ^^^ In macrophages , p38alpha and p38delta were abundant , but p38beta was undetected . p38alpha and p38delta were also expressed by neutrophils , CD4+ T cells , and endothelial cells . ^^^ IL 1beta activated p38alpha and p38beta in endothelial cells . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Finally , by selectively inhibiting p38alpha or p38beta MAPK isoforms , we demonstrate that p38alpha , rather than p38beta , MAPK activity is essential for uPA / uPAR expression . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Without stimulation endogenous p38alpha kinase activity was readily detectable , whereas that of p38beta , gamma , and delta was barely measurable . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The D domain is closely related to other MAPK docking domains , but exhibits a novel specificity and serves to promote selective targeting of ERK 2 , p38alpha , and p38beta ( 2 ) to SAP 1 . ^^^ The FXF motif promotes targeting by ERK 2 and , to a lesser extent , p38alpha , but not p38beta ( 2 ) . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| To determine whether p 38 activation was isoform selective , myocytes were infected with adenoviruses encoding wild type p38alpha or p38beta . ^^^ Transfected p38alpha and beta show differential activation ( P < 0 . 001 ) during sustained simulated ischemia , with p38alpha remaining activated ( 1 . 48+ / 0 . 36 vs . basal ) but p38beta deactivated ( 0 . 36+ / 0 . 1 vs . basal , P < 0 . 01 ) . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| However , treatment of primary fibroblasts cultured in fl coll with increasing doses of SB 203580 , an inhibitor of p38alpha and p38beta , caused a bipolar pattern of MMP 1 expression . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Using adenovirus mediated gene transfer technique , we further demonstrated that p38beta , but not p38alpha , is essential to protect the cells from TNF alpha toxicity . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The immunoreactivities of p38alpha and p38beta MAPKs were markedly increased in the brain 4 days after KA administration , especially in the areas undergoing selective neuronal loss . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Insulin dependent p 38 alpha and p 38 beta MAPK activities were also markedly reduced by wortmannin ( IC ( 50 ) = 6 and 2 nm , respectively ) . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| In vitro kinase assay of immunoprecipitates from insulin stimulated myotubes showed activation of p 38 alpha ( 2 . 6+ / 0 . 3 fold ) and p 38 beta ( 2 . 3+ / 0 . 2 fold ) MAPK . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Both vasoconstrictors activated p38alpha and / or p38beta but not p38gamma or p38delta , leading to increased HSP kinase activity . p38MAPK activation by noradrenaline was maximum between 2 and 10 minutes and was wholly dependent on calcium influx but insensitive to the tyrosine kinase inhibitor herbimycin A . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| They include extracellular signal regulated kinase 1 ( ERK 1 ) and ERK 2 ( or p 44 ( MAPK ) and p 42 ( MAPK ) ) , c Jun NH ( 2 ) terminal kinases ( JNKs ) , ERK 5 ( or BMK ) , and p 38 MAPKs , including p38alpha ( or CSBP 1 ) , p38beta , p38gamma ( or SAPK 3 or ERK 6 ) , and p38delta ? ( or SAPK 4 ) . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Among them , p 38 alpha is the best characterized isoform and many biological phenomena , especially in the inflammatory responses , were attributed to the specific inhibitor sensitive isoforms , namely p 38 alpha and p 38 beta . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Pharmaco logic inhibition of the activation of p 38 alpha and p 38 beta mitogen activated protein kinase activation potently blocked collagen driven human keratinocyte migration . ^^^ Transfection of the same keratinocytes with the kinase negative mutants of p 38 alpha or p 38 beta mitogen activated protein kinase markedly inhibited keratinocyte migration on collagen . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| During the 33rd Annual Meeting of the American Chemical Society in May 2000 , VX 745 was reported to be active against several isotypes of p 38 MAPK , including p38alpha , p38beta and p38gamma [ 368149 ] . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Although p 38 alpha , p 38 beta , and p 38 delta are expressed in keratinocytes , only a single isoform , p 38 delta , accounts for the increased p 38 activity . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Only the p38alpha and p38beta isoforms , but not the gamma or delta isoforms , complexed with Mirk . p38alphaMAPK blocked Mirk activation of HNF1alpha in a dose dependent manner , with high levels of kinase inactive p38alphaAF completely suppressing the activity of Mirk . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Here we report the differential induction of p 38 MAPK isoforms , p38alpha and p38beta , in the adult gerbil brain following transient global ischemia . ^^^ The p38alpha and p38beta kinase activities were gradually enhanced with the peak activity occurring around 2 4 days after ischemic insult . ^^^ The differential induction of p 38 MAPK isoforms following transient global ischemia , especially the induction of p38alpha and p38beta MAPKs in microglia and astrocytes , respectively , in different time points after ischemic insult suggest distinct roles of p 38 MAPK isoforms in post ischemic brain . . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Enhanced cytokine release and clustering were both inhibited by the selective p 38 alpha and p 38 beta inhibitor SB 203580 . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Next , transgenic mice with cardiac specific expression of dominant negative forms of p38alpha ( DN p38alpha ) and p38beta ( DN p38beta ) MAPK were examined . ^^^ DN p38alpha and DN p38beta mice developed cardiac hypertrophy but were resistant to cardiac fibrosis in response to pressure overload . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Remarkably , overexpression of an interfering mutant of the p38alpha isoform , but not p38beta , blocked cisplatin induced Bax activation or cytochrome c release and nuclear fragmentation . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| METHODS : With human embryonic kidney ( HEK ) 293 cells as the target and the assistance of lipofectamine mediated co transfection techniques and luciferase reporter gene systems , FLAG tagged p 38 isoforms ( namely FLAG p 38 alpha , FLAG p 38 beta ; , FLAG p 38 gamma and FLAG p 38 phi ; ) in pcDNA 3 , pcDNA 3 , piNOS Luc and pCMV beta ; were transfected into HEK 293 cells , and the relative activity of luciferase was subsequently tested . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The p 38 family of mitogen activated protein kinases includes p 38 alpha ( SAPK2a , CSBP ) , p 38 beta ( SAPK2b ) , p 38 delta ( SAPK 4 ) , and p 38 gamma ( SAPK3 / ERK6 ) . p 38 alpha and p 38 beta are widely expressed p 38 isoforms that are involved in regulation of cell proliferation , differentiation , development , and response to stress . ^^^ In this review , we discuss the role of the p 38 alpha , p 38 beta , and p 38 gamma isoforms and then present recent findings that define a role for p 38 delta as a regulator of differentiation dependent gene expression in keratinocytes . . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| This docking site was both necessary and sufficient for the high affinity binding of the MAPKs JNK 1 , JNK 2 , JNK 3 , p 38 alpha , and p 38 beta to MKK 4 . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The p 38 mitogen activated protein kinase ( MAPK ) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress . p 38 regulated / activated protein kinase ( PRAK , also known as mitogen activated protein kinase activated protein kinase 5 [ MAPKAPK 5 ] ) functions downstream of p38alpha and p38beta in mediating the signaling of the p 38 pathway . ^^^ Interestingly , ectopically expressed PRAK was localized in the nucleus and can be redistributed by coexpression of p38alpha or p38beta to the locations of p38alpha and p38beta . ^^^ Mutations in the docking groove on p38alpha / p38beta , or the p 38 docking site in PRAK , disrupted the PRAK p 38 interaction and impaired the ability of p38alpha and p38beta to redistribute ectopically expressed PRAK , indicating that the location of PRAK could be controlled by its docking interaction with p38alpha and p38beta . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| We have reported previously the delayed and differential induction of p38alpha and p38beta mitogen activated protein kinases ( MAPKs ) in microglia and astrocytes , respectively , in brain after transient global ischemia . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Cotransfection of wild type p38alpha and p38beta , but not that of p38gamma and p38delta , increased Prx 1 promoter activity . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Intraperitoneal injection of SB 202190 , an inhibitor of p38alpha and p38beta MAPK activity , markedly increased the ability of DN 14 3 3 mice to compensate for pressure overload , with decreased mortality . ^^^ DN 14 3 3 mice were bred with transgenic mice in which dominant negative p38alpha ( DN p38alpha ) or dominant negative p38beta ( DN p38beta ) MAPK expression was targeted to the heart . ^^^ Compound transgenic DN 14 3 3 / DN p38beta mice , and to a lesser extent compound transgenic DN 14 3 3 / DN p38alpha mice , exhibited reduced mortality and cardiac myocyte apoptosis in response to pressure overload , demonstrating that DN 14 3 3 promotes cardiac apoptosis due to stimulation of p 38 MAPK activity . . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Conversely , p38beta , but not p38alpha or gamma , is required for the induction of apoptosis / anoikis in HIEC 6 cells . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| These changes were reproduced by overexpression of the dominant negative p38alpha and p38beta mutants . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Differentiation stage specific activation of p 38 mitogen activated protein kinase isoforms in primary human erythroid cells . p38alpha , p38beta , p38gamma , and p38delta are four isoforms of p 38 mitogen activated protein ( MAP ) kinase ( MAPK ) involved in multiple cellular functions such as cell proliferation , differentiation , apoptosis , and inflammation response . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Nerve growth factor pretreatment attenuates oxygen and glucose deprivation induced c Jun amino terminal kinase 1 and stress activated kinases p38alpha and p38beta activation and confers neuroprotection in the pheochromocytoma PC 12 Model . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Hyperplastic mucosal explants treated with the p 38 alpha and p 38 beta inhibitor SB 203580 demonstrated significant inhibition of otitis media stimulated mucosal growth . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| In steady state kinetics experiments , CMPD 1 was observed to prevent the p38alpha dependent phosphorylation ( K ( 1 ) ( app ) = 330 nM ) of the splice variant of mitogen activated protein kinase activated protein kinase 2 ( MK2a ) that contains a docking domain for p38alpha and p38beta , but it did not prevent the phosphorylation of ATF 2 ( K ( 1 ) ( app ) > 20 microM ) . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Cells transfected with constitutively active MEK 1 or MKK 3 had increased Ihh mRNA levels , which were diminished by dominant negative MEK 1 , p38alpha or p38beta . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The specific p38alpha MAPK inhibitor SC 906 suppressed IL 1beta induced COX 2 expression but not IL 1beta induced mPGES 1 expression , suggesting preferential involvement of p38beta MAPK in IL 1beta induced mPGES 1 expression . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Studies using an antisense oligonucleotide to p38alpha demonstrated that inhibition of the protein expression of p38alpha 1 ) inhibited activation of p 38 MAP kinase without affecting the protein expression of p38beta ; 2 ) prevented phosphorylation of heat shock protein 27 , an actin binding protein that may induce actin polymerization upon phosphorylation ; 3 ) attenuated cytoskeletal changes ; and 4 ) attenuated neutrophil migration to the EC borders . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Because the p 38 isoforms that promote ( p38alpha ) or inhibit ( p38beta ) apoptosis are both suppressed by PD 169316 , we investigated their regulatory involvement in Fas signaling . ^^^ We report here , that p38alpha , but not p38beta , exerts its proapoptotic effect by inhibiting the phosphorylation and presence of c FLIPS , but not c FLIPL , in the DISC to promote caspase 8 activation and type 1 signaling in Fas activated Jurkat cells . ^^^ Potentiation of Fas mediated apoptosis by the inhibition of JNK1 / 2 correlated with the loss of Bad ( Ser 136 ) phosphorylation and was dependent on the stimulatory effect of p38alpha on DISC and the downstream effects of both p38alpha and p38beta . ^^^ These data underscore the need to reassess the findings obtained with pan p 38 inhibitors and suggest that activation of p38alpha coupled with targeted inhibition of p38beta and JNK1 / 2 should optimally sensitize tumor cells to Fas mediated apoptosis . . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Ex vivo kinase assays confirmed the increased activation of p 38 , and furthermore demonstrated increased kinase activity of the p 38 isoforms p38alpha , p38beta and p38delta in lesional compared with nonlesional psoriatic skin . p38gamma was not detected in the psoriatic skin . ^^^ CONCLUSIONS : Taken together , our results demonstrate that the activity of the MAPKs p38alpha , p38beta and p38delta and ERK1 / 2 are increased in lesional psoriatic skin compared with nonlesional psoriatic skin , and that clearance of psoriasis normalizes the p 38 and ERK1 / 2 activity . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Here we demonstrate that the isoforms are distinctly expressed in spinal dorsal horn : p38alpha in neurons and p38beta in microglia . ^^^ In these rats , down regulation of spinal p38beta , but not p38alpha , prevented nocifensive flinching evoked by intraplantar injection of formalin and hyperalgesia induced by activation of spinal neurokinin 1 receptors through intrathecal injection of substance P . ^^^ Both intraplantar formalin and intrathecal substance P produced an increase in spinal p 38 phosphorylation and this phosphorylation ( activation ) was prevented when spinal p38beta , but not p38alpha , was down regulated . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The compound BIRB 796 inhibits the stress activated protein kinases p38alpha and p38beta and is undergoing clinical trials for the treatment of inflammatory diseases . ^^^ This occurs at higher concentrations of BIRB 796 than those that inhibit p38alpha and p38beta and at lower concentrations than those that inhibit the activation of JNK isoforms . ^^^ Our results demonstrate that BIRB 796 , in combination with SB 203580 , a compound that inhibits p38alpha and p38beta , but not the other p 38 isoforms , can be used to identify physiological substrates of SAPK3 / p38gamma as well as those of p38alpha and p38beta . . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| JNK and p38alpha activation have been associated with apoptosis ; p38beta with cell survival ; and ERK with proliferation . ^^^ A significant increase in liver regeneration , as assessed by the percentage of liver weight / body weight was demonstrated in females ( 184 % + / 24 % ) and male mice given 17beta E ( 168 % + / 22 % ) compared with male mice given vehicle ( 9 % + / 4 % ) . 17beta E significantly down regulated JNK and p38alpha activities , whereas I / R 1 promoted p38beta and ERK activation . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Inhibition of p38alpha and p38beta , but not that of JNK or p38gamma and p38delta , prevented the induction of HO 1 gene expression by AEBSF . p 38 was stimulated by AEBSF in a PKB dependent manner as demonstrated by a luciferase assay with a Gal 4 CHOP fusion protein . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| This observation suggested that insulin may increase GLUT 4 activity via p38alpha and / or p38beta . ^^^ Expression of dominant negative p38alpha or p38beta reduced p38MAPK phosphorylation by 70 % but had no effect on insulin stimulated glucose uptake . ^^^ Gene silencing via isoform specific small interfering RNAs reduced expression of p38alpha or p38beta by 60 70 % without diminishing insulin stimulated glucose uptake . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| There are four isoforms of the enzyme ( p38alpha , p38beta , p38gamma and p38delta ) , which differ in tissue distribution , regulation of kinase activation and subsequent phosphorylation of downstream substrates . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The ASK 1 dependent increase in the phosphorylation of Op18 / stathmin was attenuated by the treatment with SB 203580 , suggesting that p38alpha and / or p38beta contribute to the phosphorylation of Op18 / stathmin . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| SB 203580 , a specific inhibitor of p38alpha and p38beta , similarly reduced the inhibitory phosphorylation of Cdc 2 as well as G2 / M arrest and augmented apoptosis of Daudi cells treated with etoposide . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| There are four isoforms p38alpha p38beta , p38gamma , and p38delta . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| E 2 suppressed ROS formation and p38alpha activation by H / R and concomitantly augmented the activity of p38beta . ^^^ Unlike p38alpha , p38beta was little affected by H / R . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Here , we found that the osteoclast ( Ocl ) precursors expressed p38alpha , but not p38beta , p38delta , and p38gamma isoforms . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Furthermore , chimeric analysis with p38beta ( which does not bind to TAB 1 ) revealed a previously unidentified locus of p38alpha comprising Thr 218 and Ile 275 that is essential for specific binding of p38alpha to TAB 1 . ^^^ Converting either of these residues to the corresponding amino acid of p38beta abolishes p38alpha interaction with TAB 1 . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Concomitantly , we detected a significant activation in glycogen synthase kinase 3beta ( GSK 3beta ) and p 38 MAPKs , including p38alpha , p38beta , and p38delta , but no obvious change was measured in the activity of p38gamma , ERK , and c Jun amino terminal kinase ( JNK ) . ^^^ These results provide the first in vivo evidence showing that peroxynitrite simultaneously induces tau hyperphosphorylation , nitration , and accumulation , and that activation of GSK 3beta , p38alpha , p38beta , p38delta isoforms and the inhibition of proteasome activity are respectively responsible for the peroxynitrite induced tau hyperphosphorylation and accumulation . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The antiapoptotic effect of CO in EC was abrogated when activation of the p38alpha and p38beta MAPKs was inhibited by the pyridinyl imidazole SB 202190 . ^^^ Using small interfering RNA , p38beta was found to be cytoprotective in EC , whereas p38alpha was not . ^^^ When overexpressed in EC , HO 1 targeted specifically the p38alpha but not the p38beta MAPK isoform for degradation by the 26S proteasome , an effect reversed by the 26S proteasome inhibitors MG 132 or lactacystin . ^^^ In conclusion , the antiapoptotic effect of HO 1 in EC is dependent on the degradation of p38alpha by the 26S proteasome and on the expression of p38beta . . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The injection of SIN 1 induced hyperphosphorylation of tau at pS 396 epitope with a concomitant activation of GSK 3beta and selective MAPK isoforms including p38alpha , p38beta , and p38delta but not p38gamma . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that among the different MAP kinases , the MADS box transcription factors MEF2A and MEF2C are preferentially phosphorylated and activated by the p 38 subfamily members p38alpha and p38beta2 . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The p 38 mitogen activated protein kinase ( MAPK ) group is represented by four isoforms in mammals ( p38alpha , p38beta2 , p38gamma and p38delta ) . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Overexpression of p38beta2 , but not of p38alpha , significantly decreased PDGF BB induced MMP 1 promoter activity , although PDGF BB activated signaling pathways to both p38alpha and p38beta2 . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| RT PCR analysis identified p38alpha and p38beta2 MAPK mRNA in rat cardiac myocytes . ^^^ Interleukin 1beta induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and stimulated RNA polymerase 2 binding to the COX 2 promoter , COX 2 transcription , COX 2 protein synthesis , and prostaglandin E 2 ( PGE 2 ) release . ^^^ Treatment with the p38alpha and p38beta2 MAPK inhibitor , SB 202190 , attenuated interleukin 1beta induced COX 2 transcription and accelerated the degradation of COX 2 mRNA . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| We have demonstrated that the renal mesangial cell expresses the mRNA for all the isoforms of p38MAPK , with p38alpha mRNA expressed at the highest level , followed by p38gamma and the lowest levels of expression by p38beta2 and delta . ^^^ We show that whereas p38gamma and delta had minimal effects on iNOS expression , p38alpha and beta 2 significantly altered its expression . p38alpha mutant and p38beta2 wild type dose dependently inhibited IL 1beta induced iNOS expression . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| SB 203580 , a specific p38alpha and p38beta2 MAPK inhibitor , decreased the TRAIL expression induced by IFN gamma . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| We report here the effects of 4 ( 4 fluorophenyl ) 2 ( 1 methylpiperidin 4 yl ) 5 ( 2 ( 1 ( S ) phenylethyl ) amino 4 pyridinyl ) thiazole fumarate ( Compound 1 ) , which exhibits inhibitory activity against p38alpha and p38beta2 and residual activity on c Jun amino terminal kinase ( JNK ) 2 mitogen activated protein ( MAP ) kinases , on the oedematous signals detected by MRI and generated by antigen challenge in the lungs of sensitized rats . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Stress activated protein kinase 3 ( SAPK 3 ) , a recently described MAP kinase family member with a wide spread tissue distribution , was transfected into several mammalian cell lines and shown to be activated in response to cellular stresses , interleukin 1 ( IL 1 ) and tumour necrosis factor ( TNF ) in a similar manner to SAPK 1 ( also termed JNK ) and SAPK 2 ( also termed p 38 , RK , CSBP and Mxi 2 ) . ^^^ Activation of stress activated protein kinase 3 ( SAPK 3 ) by cytokines and cellular stresses is mediated via SAPKK 3 ( MKK 6 ) ; comparison of the specificities of SAPK 3 and SAPK 2 ( RK / p38 ) . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| The glucose stimulated binding of IUF 1 to DNA and IUF 1 dependent gene transcription were both prevented by SB 203580 , a specific inhibitor of stress activated protein kinase 2 ( SAPK 2 , also termed p 38 mitogen activated protein kinase , reactivating kinase , CSBP , and Mxi 2 ) but not by several other protein kinase inhibitors . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| Sodium arsenite and osmotic shock both stimulated stress activated protein kinase 2 ( SAPK 2 , also termed RK , p 38 , CSBP and Mxi 2 ) and its downstream target mitogen activated protein kinase ( MAP kinase ) activated protein kinase 2 ( MAPKAP K 2 ) in bovine adrenal chromaffin and rat PC 12 cells . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| One of the mechanisms whereby glucose stimulates insulin gene transcription in pancreatic beta cells involves activation of the homeodomain transcription factor PDX 1 ( pancreatic / duodenal homeobox 1 ) via a stress activated pathway involving stress activated protein kinase 2 ( SAPK 2 , also termed RK / p38 , CSBP , and Mxi 2 ) . ^^^ |
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| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| In this study we show that human platelets contain the isoforms SAPK2a , SAPK2b , SAPK 3 and SAPK 4 as determined by immunoblotting with specific antibodies . ^^^ All four kinases were activated in thrombin stimulated platelets whereas only SAPK2a and SAPK2b were significantly stimulated by collagen . ^^^ The inhibitor of SAPK2a and SAPK2b , SB 202190 , completely blocked collagen induced phosphorylation of cPLA 2 at its two phosphorylation sites in vivo , Ser 505 and Ser 727 . ^^^ |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15759 and Q16539 |
Pubmed |
SVM Score :0.0 |
| NA |
|