| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| Histone deacetylase 3 , a class 1 histone deacetylase , suppresses MAPK 11 mediated activating transcription factor 2 activation and represses TNF gene expression . ^^^ Results further indicated that HDAC 3 decreases the MAPK 11 phosphorylation state and inhibits the activity of the MAPK 11 dependent transcription factor , activating transcription factor 2 ( ATF 2 ) . ^^^ Therefore , our results indicate that HDAC 3 interacts directly and selectively with MAPK 11 , represses ATF 2 transcriptional activity , and acts as a regulator of TNF gene expression in LPS stimulated cells , especially in mononuclear phagocytes . . ^^^ |
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| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| Moreover , in vitro and in vivo experiments showed a strong substrate preference by p38beta for activating transcription factor 2 ( ATF 2 ) . ^^^ Enhancement of ATF 2 dependent gene expression by p38beta was approximately 20 fold greater than that of p 38 and other MAP kinases tested . ^^^ |
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| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| In contrast to p 38 and p 38 beta , p 38 gamma , fails to phosphorylate ATF 2 or MAPKAP kinase 2 but does like other MAP kinases phosphorylate MBP . ^^^ |
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| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| MBP , ATF 2 , and both MAPKAP kinase 2 and kinase 3 were good substrates of p 38 and p38beta in vitro . ^^^ In contrast , only MBP , ATF 2 , and MAPKAP kinase 3 proved to be significant substrates of SAPK 3 and SAPK 4 , and of these three , MAPKAP kinase 3 was by far the weakest . p38beta had very poor kinase activity for all substrates except MBP . ^^^ |
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| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| Both enzymes phosphorylated the transcription factors ATF 2 , Elk 1 and SAP 1 at similar rates , but were far less effective than SAPK2a ( also called RK / p38 ) or SAPK2b ( also called p38beta ) in activating MAPKAP kinase 2 and MAPKAP kinase 3 . ^^^ |
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| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that p38beta mitogen activated protein ( MAP ) kinase augments ATF 2 transactivation activity on the PEPCK C promoter , which is consistent with the interpretation that PEPCK C promoter activity is maintained under stress through a p 38 MAP kinase dependent pathway . ^^^ |
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| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that RA treatment potentiates ATF 2 dependent transactivation by inducing specific phosphorylation of ATF 2 by p38beta kinase . ^^^ ATF 2 activation by RA blocked the inhibitory intramolecular interaction of ATF 2 amino and carboxyl terminal domains in a p38beta kinase dependent manner . ^^^ Taken together , the data suggest that RA activates the p38beta kinase pathway leading to phosphorylation and activation of ATF 2 , thereby enhancing PEPCK gene transcription and glucose production . . ^^^ |
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| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the molecular interaction of ATF 2 and ASC 2 was stimulated by RA treatment and inhibited by p38beta kinase inhibitor . ^^^ |
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| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| In the present study , we provide evidence showing that UVC stimulated phosphorylation of ATF 2 ( Thr 71 ) was to varying degrees prevented by a dominant negative mutant of p38beta kinase , c Jun N terminal kinase 1 ( JNK 1 ) or extracellular signal regulated kinase 2 ( ERK 2 ) . ^^^ |
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| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| In steady state kinetics experiments , CMPD 1 was observed to prevent the p38alpha dependent phosphorylation ( K ( 1 ) ( app ) = 330 nM ) of the splice variant of mitogen activated protein kinase activated protein kinase 2 ( MK2a ) that contains a docking domain for p38alpha and p38beta , but it did not prevent the phosphorylation of ATF 2 ( K ( 1 ) ( app ) > 20 microM ) . ^^^ |
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| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| SAPK 3 and SAPK 2 phosphorylated a number of proteins at similar rates , including the transcription factors ATF 2 , Elk 1 and SAP 1 , but SAPK 3 was far less effective than SAPK 2 in activating MAPKAP kinase 2 and MAPKAP kinase 3 . ^^^ SAPK 3 phosphorylated ATF 2 at Thr 69 , Thr 71 and Ser 90 , the same residues phosphorylated by SAPK 1 , whereas SAPK 2 only phosphorylated Thr 69 and Thr 71 . ^^^ |
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| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15759 and P15336 |
Pubmed |
SVM Score :0.0 |
| NA |
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