| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| The recent identification of loss of function mutations in GPR 54 , a receptor for kisspeptin 1 , has highlighted a new pathway for the timing of puberty and reproductive control . . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Mechanisms of Disease : the first kiss a crucial role for kisspeptin 1 and its receptor , G protein coupled receptor 54 , in puberty and reproduction . ^^^ Ligands for G protein coupled receptor 54 ( KiSS 1R ) , including metastin ( derived from the parent compound , kisspeptin 1 ) and metastin ' s C terminal peptide fragments , have been shown to be powerful stimulants for GnRH release in vivo via their stimulation of G protein coupled receptor 54 . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| AXOR 12 , a novel human G protein coupled receptor , activated by the peptide KiSS 1 . ^^^ Quantitative reverse transcriptase polymerase chain reaction was used to study the expression of AXOR 12 and KiSS 1 in a variety of tissues . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| We examined the genes encoding GPR 54 and its putative endogenous ligand , kisspeptin 1 , for mutations in a cohort of 30 patients with normosmic HH or delayed puberty . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| The metastasis suppressor gene KiSS 1 encodes kisspeptins , the natural ligands of the orphan G protein coupled receptor GPR 54 . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| We recently reported having identified of the ligand for an orphan G protein coupled receptor , hOT7T175 , as the gene product ( 68 121 ) amide of the metastasis suppressor gene KiSS 1 . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| In this study , we identified the mouse homologues of the KiSS 1 peptide and its G protein coupled receptor and characterized the signaling pathways mediated by the activation of the KiSS 1 receptor . ^^^ Furthermore , activation of the KiSS 1 receptor inhibits cell proliferation and cell migration , key characteristics of tumor metastasis . . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Quantitative PCR was used to measure , in trophoblast cells , the transcriptional expression profiles of four genes , INSL 4 , BRMS 1 , KiSS 1 and KiSS 1R , reported to be implicated in tumor invasion and metastasis . ^^^ Laser capture microdissection and purification of trophoblast cells demonstrate that , as already known for INSL 4 , BRMS 1 , KiSS 1 and KiSS 1R are expressed by the trophoblast subset of placental tissues . ^^^ Low levels of expression of BRMS 1 were observed in normal pregnancies , in molar pregnancies and in choriocarcinoma cell lines BeWo , JAR and JEG 3 while , in striking contrast , the expression levels of INSL 4 , KiSS 1 and Kiss 1R were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells . ^^^ These transcriptional expression profiles are in favor of a predominant role of INSL 4 , KiSS 1 and KiSS 1R in the control of the invasive and migratory properties of trophoblast cells . . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Metastin , the product of metastasis suppressor gene KiSS 1 , is proposed to be the natural ligand for the G protein coupled receptor GPR 54 , known also as AXOR 12 . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Recent identification of a 54 amino acid peptide of KISS 1 , termed metastin or kisspeptin 54 , and its cognate G protein coupled receptor ( hOT7T175 , AXOR 12 , GPR 54 ) have provided additional clues and avenues of research . ^^^ Nevertheless , mounting clinical evidence , particularly the loss of KISS 1 in metastases , correlates KISS 1 and metastin receptor expression with human tumor progression . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| KiSS 1 protein is known to be processed to peptide ligand of a G protein coupled receptor ( hOT7T175 ) named metastin , and suppresses metastasis of tumors expressing the receptor . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Hypogonadotropic hypogonadism due to loss of function of the KiSS 1 derived peptide receptor GPR 54 . ^^^ Recently , a 54 aa peptide derived from the KiSS 1 protein was identified as a ligand of GPR 54 . ^^^ The present study shows that loss of function of GPR 54 is a cause of IHH , and it identifies GPR 54 and possibly KiSS 1 protein derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis . . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| The KiSS 1 receptor GPR 54 is essential for the development of the murine reproductive system . ^^^ The ligand for GPR 54 has been identified as a peptide derived from the KiSS 1 gene . ^^^ These data suggest a role for GPR54 / KiSS 1 in normal sexual development , and indicate that study of the GPR 54 mutant mice may provide valuable insights into human reproductive syndromes . . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Clinical significance of the loss of KiSS 1 and orphan G protein coupled receptor ( hOT7T175 ) gene expression in esophageal squamous cell carcinoma . ^^^ Recently , KiSS 1 was cloned as a human metastasis suppressor gene , and an orphan G protein coupled receptor ( hOT7T175 ) was identified as the endogenous receptor of the KiSS 1 product . ^^^ However , the clinical importance of KiSS 1 and hOT7T175 gene expression in ESCC remains unclear . ^^^ The expression levels of KiSS 1 , hOT7T175 , and glyceraldehyde 3 phosphate dehydrogenase ( GAPDH ) mRNAs were analyzed quantitatively by real time reverse transcription PCR and compared with the clinical findings . ^^^ RESULTS : The mean KiSS 1 : GAPDH and hOT7T175 : GAPDH ratios of the tumors were 1 . 2 and 0 . 3 and were at the same levels as those in the noncancerous epithelia . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS 1 and orphan G protein coupled receptor ( hOT7T175 ) gene expression in hepatocellular carcinoma . ^^^ PURPOSE : KiSS 1 has been cloned as a human metastasis suppressor gene and an orphan G protein coupled receptor ( hOT7T175 ) identified as the endogenous receptor of the KiSS 1 product . ^^^ In the present study , we evaluated the clinical importance of KiSS 1 and hOT7T175 gene expression in hepatocellular carcinoma ( HCC ) . ^^^ METHODS : The expression levels of KiSS 1 , hOT7T175 and glyceraldehyde 3 phosphate dehydrogenase ( GAPDH ) messenger RNAs ( mRNAs ) were analyzed quantitatively by real time reverse transcriptase polymerase chain reaction ( RT PCR ) in 60 surgically resected HCCs . ^^^ The KiSS 1 / GAPDH and hOT7T175 / GAPDH ratios of tumors were compared with clinicopathological findings . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Kisspeptin is the peptide product of the KiSS 1 gene and the endogenous agonist for the GPR 54 receptor . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Metastin , a post translationally modified variant of KiSS 1 , was recently identified as an endogenous peptide agonist for a novel G protein coupled receptor , hOT7T175 ( AXOR 12 , GPR 54 ) . ^^^ In this study , we analyzed the role of KiSS 1 and hOT7T175 in both pancreatic cancer tissues and pancreatic cancer cell lines . ^^^ Pancreatic cancer tissues showed significantly lower expression of KiSS 1 mRNA than normal tissues ( p=0 . 018 ) , while cancer tissues showed significantly higher expression of hOT7T175 mRNA than normal pancreatic tissues ( p=0 . 027 ) . ^^^ In human pancreatic cancer cell lines , KiSS 1 mRNA was highly expressed in 2 out of 6 pancreatic cancer cell lines , while hOT7T175 mRNA was expressed in all cell lines at various degrees . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Kisspeptins are products of the KiSS 1 gene , which bind to a G protein coupled receptor known as GPR 54 . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS 1 and its putative receptor , GPR 54 , in rat hypothalamus and potent luteinizing hormone releasing activity of KiSS 1 peptide . ^^^ Recently , loss of function mutations of the gene encoding G protein coupled receptor 54 ( GPR 54 ) , the putative receptor for the KiSS 1 derived peptide metastin , have been associated with lack of puberty onset and hypogonadotropic hypogonadism . ^^^ In the present work , expression analyses of KiSS 1 and GPR 54 genes were conducted in different physiological and experimental settings , and the effects of central administration of KiSS 1 peptide on LH release were assessed in vivo . ^^^ Persistent expression of KiSS 1 and GPR 54 mRNAs was detected in rat hypothalamus throughout postnatal development , with maximum expression levels at puberty in both male and female rats . ^^^ Hypothalamic expression of KiSS 1 and GPR 54 genes changed throughout the estrous cycle and was significantly increased after gonadectomy , a rise that was prevented by sex steroid replacement both in males and females . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Characterization of the potent luteinizing hormone releasing activity of KiSS 1 peptide , the natural ligand of GPR 54 . ^^^ Loss of function mutations of the gene encoding GPR 54 , the putative receptor for the KiSS 1 derived peptide metastin , have been recently associated with hypogonadotropic hypogonadism , in both rodents and humans . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Advanced vaginal opening and precocious activation of the reproductive axis by KiSS 1 peptide , the endogenous ligand of GPR 54 . ^^^ Recently , loss of function mutations of the gene encoding GPR 54 , the putative receptor for the KiSS 1 derived peptide metastin , have been linked to hypogonadotrophic hypogonadism , both in rodents and humans . ^^^ Overall , the present results , together with our recent data on maximum expression of KiSS 1 and GPR 54 genes in the hypothalamus at puberty , provide novel evidence for a role of the KiSS 1 system as a downstream element in the hypothalamic network triggering the onset of puberty . . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| The kisspeptins are the peptide products of the KiSS 1 gene and the endogenous agonists for the GPR 54 receptor . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Metastin , the gene product of metastasis suppressor gene KiSS 1 , is the endogenous ligand for the G protein coupled receptor GPR 54 ( or AXOR 12 , or OT7T175 ) . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| GPR 54 is a receptor for peptides derived from the metastasis suppressor gene KiSS 1 . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| New gatekeepers of reproduction : GPR 54 and its cognate ligand , KiSS 1 . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| The KiSS 1 gene codes for a family of neuropeptides called kisspeptins which bind to the G protein coupled receptor GPR 54 . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| To further study the role of GPR 54 signaling in the onset of primate puberty , we used the monkey to examine the ability of kisspeptin 10 to elicit the release of gonadotropin releasing hormone ( GnRH ) precociously , and we describe the expression of GPR 54 and KiSS 1 in the hypothalamus during the peripubertal period . ^^^ Hybridization histochemistry indicated robust KiSS 1 and GPR 54 mRNA expression in the region of the arcuate nucleus . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Effects of KiSS 1 peptide , the natural ligand of GPR 54 , on follicle stimulating hormone secretion in the rat . ^^^ KiSS 1 was originally identified as a metastasis suppressor gene encoding an array of structurally related peptides , namely kisspeptins , which acting through the G protein coupled receptor GPR 54 are able to inhibit tumor progression . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Kisspeptins are products of the Kiss 1 gene , which bind to GPR 54 , a G protein coupled receptor . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Recently , KiSS 1 gene derived kisspeptin , signaling through the G protein coupled receptor 54 ( GPR 54 ) , has been proven as a pivotal regulator in the control of gonadotropin secretion and puberty . ^^^ In this work , we evaluated the expression of KiSS 1 and GPR 54 genes at the hypothalamus as well as the ability of kisspeptin 10 to elicit GnRH and LH secretion in prepubertal rats under short term fasting . ^^^ Food deprivation induced a concomitant decrease in hypothalamic KiSS 1 and increase in GPR 54 mRNA levels in prepubertal rats . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Quantitative RT PCR has revealed that KiSS 1 and GPR 54 mRNAs were expressed in the ARC and POA , respectively . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Metastin , a product of the KiSS 1 gene , is an endogenously expressed metastasis suppressor that is the ligand for G protein coupled receptor 54 ( GPR 54 ) , a Gq / 11 coupled receptor . ^^^ KiSS 1 / G protein coupled receptor 54 metastasis suppressor pathway increases myocyte enriched calcineurin interacting protein 1 expression and chronically inhibits calcineurin activity . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| The Kiss 1 gene encodes a family of neuropeptides named kisspeptins , which bind to a ( former orphan ) G protein coupled receptor called GPR 54 . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Kisspeptins , products of the KiSS 1 gene with ability to bind G protein coupled receptor 54 ( GPR 54 ) , have been recently identified as major gatekeepers of reproductive function with ability to potently activate the GnRH / LH axis . ^^^ In this work , we evaluated maximal LH and FSH secretory responses to kisspeptin 10 , as well as changes in sensitivity and hypothalamic expression of KiSS 1 and GPR 54 genes , in different physiological and experimental models in the adult female rat . ^^^ Interestingly , hypothalamic KiSS 1 gene expression significantly increased during pregnancy , whereas GPR 54 mRNA levels remained unaltered . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| KiSS 1 and GPR 54 as new players in gonadotropin regulation and puberty . ^^^ The recent identification of loss of function mutations in the gene encoding GPR 54 , the receptor for the KiSS 1 derived peptides , kisspeptins , has highlighted a previously unrecognized pathway in the physiologic regulation of puberty and reproduction . ^^^ This hypothesis is supported by subsequent studies in rodent and primate models that have demonstrated localization of KiSS 1 mRNA in the hypothalamus , colocalization of GPR 54 in GnRH neurons , GnRH dependent activation of LH and FSH release by intracerebroventricular or peripheral administration of kisspeptin , and increased hypothalamic KiSS 1 and GPR 54 mRNA levels at the onset of puberty . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| The Kiss 1 gene encodes a family of neuropeptides called kisspeptins , which activate the receptor G protein coupled receptor 54 and play a role in the neuroendocrine regulation of GnRH secretion . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| RT PCR experiments showed that both KiSS 1 and GPR 54 are expressed in the hippocampal dentate gyrus . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| These findings are consistent with the notion that , in primates , the transition from the juvenile ( attenuated GnRH release ) to pubertal ( robust GnRH release ) state is controlled by activation of GPR 54 resulting from increased expression of hypothalamic KiSS 1 and release of kisspeptin in this region of the brain . . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| A polypeptide derived from the KiSS 1 product , designated kisspeptin 10 ( Kp 10 ) , activates a receptor coupled to Galphaq subunits ( GPR 54 or KiSS 1R ) . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| There were no such trends with the KiSS 1 receptor . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| The Kiss 1 gene encodes a family of peptides called kisspeptins , which bind to the G protein coupled receptor GPR 54 . ^^^ Hypothalamic levels of Kiss 1 and GPR 54 mRNA increase dramatically at puberty , suggesting that kisspeptin signaling could mediate the neuroendocrine events that trigger the onset of puberty . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| The Kiss 1 gene codes for a family of peptides that act as endogenous ligands for the G protein coupled receptor GPR 54 . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Kisspeptin 54 is the peptide product of the KiSS 1 gene and an endogenous agonist of the GPR 54 receptor . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Recent data indicate that the product of the KiSS 1 gene is a potent stimulator of the hypothalamic pituitary gonadal axis and may play , together with its receptor GPR 54 , a central role in the neuroendocrine regulation of gonadotropin secretion . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Kisspeptins , the peptide products of the KiSS 1 gene , were identified in 2001 as natural ligands of the previously orphan G protein coupled receptor , GPR 54 . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Kisspeptins , which are products of the Kiss 1 gene , and their receptor , GPR 54 , have emerged as key players in the regulation of gonadotropin releasing hormone ( GnRH ) secretion . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Kisspeptins , the products of KiSS 1 gene , and their receptor , GPR 54 , have recently emerged as essential gatekeepers of reproduction , mainly through regulation of GnRH secretion at the hypothalamus . ^^^ However , the profound hypogonadotropism linked to GPR 54 inactivation is likely to mask additional functions of this system at other levels of the gonadal axis , in which expression of KiSS 1 and GPR 54 has been preliminarily reported . ^^^ KiSS 1 and GPR 54 mRNAs were persistently detected in adult ovary along estrous cycle . ^^^ Yet , contrary to GPR 54 , ovarian KiSS 1 levels fluctuated in a cyclic dependent manner , with a robust increase in the afternoon of proestrus , i . e . preceding ovulation . ^^^ |
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| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| Kisspeptins , ligands of G protein coupled receptor 54 ( GPR 54 ) encoded by the KiSS 1 gene , have recently emerged as major gatekeepers of the gonadotropic axis . ^^^ |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15726 and Q969F8 |
Pubmed |
SVM Score :0.0 |
| NA |
|