| The role of KiSS 1 and matrix metalloproteinase 9 in regulation of invasion of trophoblasts ] . ^^^ METHODS : RT PCR and Western blotting were used to detect the MMP 9 and KiSS 1 expression levels in the placental tissues obtained from 90 cases of normal pregnant women undergoing artificial abortion , induction of labor with water bag or selective cesarean section among which 30 cases were in the first trimester , 30 in second trimester and 30 cases of term pregnancy , and in the placental tissues of 40 cases of preeclampsia ( 15 cases of mild and 25 cases of severe preeclampsia ) undergoing cesarean section , and tissues of 90 cases of hydatidiform mole , 9 cases of invasive mole and 8 cases of choriocarcinoma , all undergoing surgery . ^^^ The KISS 1 mRNA expression level and MMP 9 protein expression level in the placental tissue of preeclampsia were 0 . 09 + / 0 . 06 ( A value ) and ( 9 . 6 + / 4 . 3 ) microg / 100 microg total protein respectively , both significantly lower than those of the term placenta ( both P < 0 . 01 ) . ^^^ CONCLUSION : The expression of the invasion related gene , MMP 9 , is positively related with , while the invasion suppressor gene , KiSS 1 , is negatively related with the invasive ability of trophoblasts . ^^^ |