| TRIP 6 also interacts with TRAF 2 , a protein that is crucially involved in TNF signaling , as well as the IL 1 receptor , TLR 2 and Nod 1 . ^^^ Overexpression of TRIP 6 potentiates NF kappaB activation by TNF , IL 1 , TLR 2 or Nod 1 , whereas a dominant negative mutant or RNA interference construct of TRIP 6 inhibits NF kappaB activation by TNF , IL 1 , TLR 2 or Nod 1 . ^^^ |