| Interacting proteins: Q9Y297 and Q15653 |
Pubmed |
SVM Score :1.0926266 |
| We demonstrate that beta TrCP interacts specifically with IkappaBbeta , and such interaction is dependent on prior phosphorylation of IkappaBbeta on serines 19 and 23 . 1.0926266^^^ |
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| Interacting proteins: Q9Y297 and Q15653 |
Pubmed |
SVM Score :0.0 |
| We have now generated mice deficient in beta TrCP 1 and shown that the degradation of 1 kappa B alpha and 1 kappa B beta is reproducibly , but not completely , impaired in the cells of these animals . ^^^ |
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| Interacting proteins: Q9Y297 and Q15653 |
Pubmed |
SVM Score :0.0 |
| Common pathway for the ubiquitination of IkappaBalpha , IkappaBbeta , and IkappaBepsilon mediated by the F box protein FWD 1 . ^^^ However , in contrast to IkappaBalpha and IkappaBbeta , the recognition site in IkappaBepsilon for FWD 1 is not restricted to the DSGPsiXS motif ; FWD 1 also interacts with other sites in the NH ( 2 ) terminal region of IkappaBepsilon . ^^^ Substitution of the critical serine residues in the NH ( 2 ) terminal regions of IkappaBalpha , IkappaBbeta , and IkappaBepsilon with alanines also markedly reduced the extent of FWD 1 mediated ubiquitination of these proteins and increased their stability . ^^^ |
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