| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| The IKK complex in the absence of IKK 1 is capable of phosphorylating IkappaBalpha and IkappaBbeta in vitro . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| We recently purified a large multiprotein complex , the IkappaB kinase ( IKK ) signalsome , which contains two regulated IkappaB kinases , IKK 1 and IKK 2 , that can each phosphorylate IkappaBalpha and IkappaBbeta . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| TF 3 strongly inhibited both IKK 1 and IKK 2 activity and prevented the degradation of IkappaBalpha and IkappaBbeta in activated macrophage cells . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| Here we show that in response to poly ( rI ) . poly ( rC ) ( pIC ) , PKR activates IkappaB kinase ( IKK ) , leading to the degradation of the inhibitors IkappaBalpha and IkappaBbeta and the concomitant release of NF kappaB . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| However , aging did not affect the protein levels of the main 1 kappa B inhibitors ( 1 kappa B alpha and 1 kappa B beta ) or 1 kappa B kinase ( IKK ) complex subunits ( IKK alpha , beta , and gamma ) involved in NF kappa B activation . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| Two of these polypeptides , IKK alpha and IKK beta , also known as IKK 1 and IKK 2 , are the catalytic subunits of the kinase complex and phosphorylate 1 kappa B alpha and 1 kappa B beta . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| Stimulation with TNF alpha induced a > 10x increase in 1 kappa B kinase ( IKK ) activity that quickly diminished by 20 min . 1 kappa B alpha and 1 kappa B beta proteins were degraded during this time , and 1 kappa B alpha was resynthesized subsequently by NF kappa B dependent transcription . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| We recently reported that activation of rat mdr1b in cultured cells by 2 AAF involves a cis activating element containing a NF kappaB binding site located 167 to 158 of the rat mdr1b promoter . 2 AAF activates IkappaB kinase ( IKK ) , resulting in degradation of IkappaBbeta and activation of NF kappaB . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| Cerulein induces NF kappaB / Rel via activation of IkappaB kinase ( IKK ) , which causes degradation of IkappaBalpha but not IkappaBbeta . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| Human T lymphotropic virus type 1 tax activates 1 kappa B kinase by inhibiting 1 kappa B kinase associated serine / threonine protein phosphatase 2A . 1 kappa B kinase ( IKK ) is a serine / threonine kinase that phosphorylates 1 kappa B alpha and 1 kappa B beta and targets them for polyubiquitination and proteasome mediated degradation . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| This increase in NF kappaB activation caused by proteasome inhibitors was accompanied by an increase in IkappaB kinase activation and a degradation of IkappaBalpha but not IkappaBbeta . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| Moreover , CHS 828 has also been shown to inhibit the LPS induced degradation of the 1 kappa B alpha and 1 kappa B beta in THP 1 cells , leading us to identify the 1 kappa B kinase complex as a molecular target of CHS 828 . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| Because NF kappaB translocates to the nucleus upon the phosphorylation and degradation of inhibitor of IkappaB , we also used Western blots to measure cytosolic protein levels of IkappaBalpha and IkappaBbeta , and the IkappaB kinases , IKKalpha and IKKbeta . ^^^ |
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| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| Coexpression of IkappaBalpha , IkappaBbeta , IKKalpha , IKKbeta , NIK and TRAF 2 dominant negative constructs , with LMP 1 inhibited the activation of the CCL 5 promoter by LMP 1 , suggesting that LMP 1 induces CCL 5 via NF kappaB signaling . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| The alteration in NF kappaB DNA binding activity was neither accompanied by any change in the expression of the inhibitor kappaB ( IkappaB ) kinases , IKKalpha , IKKbeta , and IKKgamma nor in the expression of the NF kappaB inhibitor proteins , IkappaBalpha and IkappaBbeta . ^^^ |
|
| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| Eight weeks later we measured TBARS and hydroperoxide initiated chemiluminescence ( QL ) in liver as markers of oxidative stress , and activities of the antioxidant enzymes catalase , superoxide dismutase ( SOD ) , and glutathione peroxidase , NF kappaB activation by an electrophoretic mobility shift assay and expression of IkappaB kinases ( IKKalpha and IKKbeta ) , the inhibitor IkappaB ( IkappaBalpha and IkappaBbeta ) , and iNOS by Western blot . ^^^ |
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| Interacting proteins: Q15653 and O15111 |
Pubmed |
SVM Score :0.0 |
| Ang 2 also decreased the cytosolic level of the inhibitor of NF kappaB ( IkappaB ) and increased the phosphorylation of IkappaB subunits , IkappaBalpha and IkappaBbeta , as well as the phosphorylation of IkappaB kinase ( IKK ) subunits , IKKalpha and IKKbeta , suggesting that Ang 2 enhanced the breakdown of IkappaB . ^^^ |
|