| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| We recently purified a large multiprotein complex , the IkappaB kinase ( IKK ) signalsome , which contains two regulated IkappaB kinases , IKK 1 and IKK 2 , that can each phosphorylate IkappaBalpha and IkappaBbeta . ^^^ |
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| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| TF 3 strongly inhibited both IKK 1 and IKK 2 activity and prevented the degradation of IkappaBalpha and IkappaBbeta in activated macrophage cells . ^^^ |
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| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| We employed a retroviral infection approach to stably express transdominant ( TD ) mutants of IkappaBalpha , IkappaBbeta , or IkappaBepsilon and dominant negative ( dn ) versions of IkappaB kinases ( IKK ) 1 or 2 as well as a constitutively active version of IKK 2 in human endothelial cells . ^^^ |
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| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| IKKgamma / NEMO binding to wild type , but not to a kinase deficient IKKbeta protein , facilitated the association of IkappaBalpha and IkappaBbeta with the high molecular weight IKK complex . ^^^ |
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| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| Two of these polypeptides , IKK alpha and IKK beta , also known as IKK 1 and IKK 2 , are the catalytic subunits of the kinase complex and phosphorylate 1 kappa B alpha and 1 kappa B beta . ^^^ |
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| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| The suppressive activity of hTid 1 on IKKbeta requires a functional J domain that mediates association with heat shock proteins and results in prolonging the half life of the NF kappaB inhibitors IkappaBalpha and IkappaBbeta . ^^^ |
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| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| However , IKK beta phosphorylates the N terminal serines of 1 kappa B beta far less efficiently , thereby providing an explanation for the slower rate of degradation observed for 1 kappa B beta . ^^^ |
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| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| Remarkably , kappaB Ras functions in both GDP and GTP bound states , and mutations of the conserved guanine binding residues of kappaB Ras abrogate its ability to block degradation of IkappaBbeta . kappaB Ras also directly blocks the in vitro phosphorylation of IkappaBbeta by IKKbeta . ^^^ |
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| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| Because NF kappaB translocates to the nucleus upon the phosphorylation and degradation of inhibitor of IkappaB , we also used Western blots to measure cytosolic protein levels of IkappaBalpha and IkappaBbeta , and the IkappaB kinases , IKKalpha and IKKbeta . ^^^ |
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| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| Coexpression of IkappaBalpha , IkappaBbeta , IKKalpha , IKKbeta , NIK and TRAF 2 dominant negative constructs , with LMP 1 inhibited the activation of the CCL 5 promoter by LMP 1 , suggesting that LMP 1 induces CCL 5 via NF kappaB signaling . ^^^ |
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| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| The alteration in NF kappaB DNA binding activity was neither accompanied by any change in the expression of the inhibitor kappaB ( IkappaB ) kinases , IKKalpha , IKKbeta , and IKKgamma nor in the expression of the NF kappaB inhibitor proteins , IkappaBalpha and IkappaBbeta . ^^^ |
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| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| Eight weeks later we measured TBARS and hydroperoxide initiated chemiluminescence ( QL ) in liver as markers of oxidative stress , and activities of the antioxidant enzymes catalase , superoxide dismutase ( SOD ) , and glutathione peroxidase , NF kappaB activation by an electrophoretic mobility shift assay and expression of IkappaB kinases ( IKKalpha and IKKbeta ) , the inhibitor IkappaB ( IkappaBalpha and IkappaBbeta ) , and iNOS by Western blot . ^^^ |
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| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| Ang 2 also decreased the cytosolic level of the inhibitor of NF kappaB ( IkappaB ) and increased the phosphorylation of IkappaB subunits , IkappaBalpha and IkappaBbeta , as well as the phosphorylation of IkappaB kinase ( IKK ) subunits , IKKalpha and IKKbeta , suggesting that Ang 2 enhanced the breakdown of IkappaB . ^^^ |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15653 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|