| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.58964519 |
| TRBP interacts with the interferon induced protein kinase R ( PKR ) and inhibits its activity . 0.58964519^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.70061764 |
| Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA dependent protein kinase PKR . 0.70061764^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.0 |
| TRBP inhibited phosphorylation of the interferon induced ribosome associated protein kinase PKR and of the eukaryotic translation initiation factor eIF 2 alpha in a transient expression system in which the translation of a reporter gene was inhibited by the localized activation of PKR . ^^^ These results implicate TRBP as a cellular regulatory protein that binds RNAs containing specific secondary structure ( s ) to mediate the inhibition of PKR activation and stimulate translation in a localized manner . . ^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.0 |
| The mammalian dsRNA binding protein TRBP , originally identified on the basis of its ability to bind the transactivation region ( TAR ) of human immunodeficiency virus RNA , also dimerized with itself and with PKR in the yeast assay . ^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.0 |
| In transfection assays , TRBP has also been shown to inhibit the interferon induced protein kinase PKR possibly by direct physical interaction . ^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.0 |
| In contrast , other inhibitors of PKR including vaccinia virus E3L and K3L gene products , and the HIV trans activating response ( TAR ) element binding protein TRBP , did not disrupt ribosome association of PKR . ^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.0 |
| These domains are conserved with the cis acting transactivation response element ( TAR ) binding protein ( TRBP ) and dsRNA activated protein kinase ( PKR ) . ^^^ TRBP and PKR are involved in the regulation of HIV 1 gene expression through their binding to TAR RNA . ^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.0 |
| The TAR RNA binding protein , TRBP , stimulates the expression of TAR containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA dependent kinase PKR . ^^^ TRBP ( HIV 1 transactivating response ( TAR ) RNA binding protein ) and PKR , the interferon induced dsRNA regulated protein kinase , contain two dsRNA binding domains . ^^^ TRBP and PKR can heterodimerize , which inhibits the kinase function of PKR and has a positive effect on HIV 1 expression . ^^^ Addition of TRBP restored translation efficiency of TAR CAT RNA and decreased the phosphorylation status of eIF 2alpha , confirming its role as a PKR inhibitor . ^^^ TRBP inhibited eIF 2alpha phosphorylation in both cases , suggesting that it restores the translation of TAR CAT RNA independently and in addition to its ability to inhibit PKR . ^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.0 |
| The carboxy terminal , M 3 motifs of PACT and TRBP have opposite effects on PKR activity . ^^^ The human TAR ( trans activating region ) binding protein ( TRBP ) , which is very homologous to PACT , also interacts with PKR , leading to an inhibition of PKR activity . ^^^ Our results indicate that TRBP and PACT interact with PKR through the same residues , and no differences were identified in these two interactions . ^^^ Domain swap experiments between PACT and TRBP indicated that the inhibitory effects of TRBP on PKR activity are mediated through its carboxy terminal residues , which contain TRBP ' s third dsRNA binding motif . . ^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.0 |
| TRBP , PKR and La bind directly to the TAR RNA structure and influence translation of HIV 1 in either positive or negative manners . ^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.0 |
| TRBP , a regulator of cellular PKR and HIV 1 virus expression , interacts with Dicer and functions in RNA silencing . ^^^ TRBP had previously been assigned several functions , including inhibition of the interferon induced double stranded RNA regulated protein kinase PKR and modulation of HIV 1 gene expression by association with TAR . ^^^ The TRBP Dicer interaction shown raises interesting questions about the potential interplay between RNAi and interferon PKR pathways . . ^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.0 |
| Low TRBP levels support an innate human immunodeficiency virus type 1 resistance in astrocytes by enhancing the PKR antiviral response . ^^^ The heightened PKR response results from relatively low levels of the cellular antagonist of PKR , the TAR RNA binding protein ( TRBP ) . ^^^ Therefore , the robust innate PKR antiviral response in astrocytes results from relatively low levels of TRBP expression and contributes to their restricted infection . ^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.0 |
| TRBP has been isolated as an HIV 1 TAR RNA binding protein that increases HIV expression and replication by inhibiting PKR and by increasing translation of structured RNAs . ^^^ A recent report published in the Journal of Virology shows that the poor replication of HIV in astrocytes is mainly due to a heightened PKR response that can be overcome by supplying TRBP exogenously . ^^^ |
|
| Interacting proteins: Q15633 and P19525 |
Pubmed |
SVM Score :0.0 |
| The trans activation response ( TAR ) RNA binding protein 2 ( TRBP 2 ) increases HIV 1 LTR expression through TAR and protein kinase R ( PKR ) binding , but not through interactions with the Tat CycT 1 CDK9 complex . ^^^ |
|