| Interacting proteins: Q93038 and Q15628 |
Pubmed |
SVM Score :0.0 |
| DR 3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD , TRAF 2 , FADD , and FLICE . ^^^ |
|
| Interacting proteins: Q93038 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Transcriptional expression of TNFR 1 ( p 55 ) , as well as that of FLICE , Fas , FADD , DR 3 , FAF , TRADD , and RIP was similar in these cell lines , indicating that the susceptibility to TNFalpha induced apoptosis may not be determined by the constitutive expression level of these factors . ^^^ |
|
| Interacting proteins: Q93038 and Q15628 |
Pubmed |
SVM Score :0.0 |
| TL1A induced the formation of a DR 3 signaling complex containing TRADD , TRAF 2 , and RIP and activated the NF kappaB and the ERK , JNK , and p 38 mitogen activated protein kinase pathways . ^^^ |
|
| Interacting proteins: Q93038 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor ( TNF ) receptor 1 associated death domain protein ( TRADD ) is an adaptor protein known to be involved in the TNF signaling pathway as well as signaling of other members of the TNF receptor superfamily , including DR 3 , DR 6 , p 75 ( NTR ) , and the Epstein Barr virus latent membrane protein 1 . ^^^ |
|
| Interacting proteins: Q93038 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Taken together , these observations suggested that camptothecin and VP 16 induced rapid aggregation of DR 4 and DR 3 , but paradoxically , the importance of these events in signaling apoptosis is uncertain , because the kinetics of apoptosis were unaffected , even in the presence of a high expression level of SODD , FADD DN , TRADD ND , and DAP 3 DN . ^^^ |
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| Interacting proteins: Q93038 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Some members of the DR family , CD 95 and the TRAIL receptors DR 4 and DR 5 , directly bind FADD , whereas others , such as TNF receptor 1 and DR 3 , initially bind another adaptor protein , TRADD , which then recruits FADD . ^^^ |
|
| Interacting proteins: Q93038 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Mutation of charged residues in the TR 3 death domain does not perturb interaction with TRADD . ^^^ We performed alanine scanning mutagenesis of specific charged residues in the TR 3 death domain to determine whether they play a crucial role in TR 3 TR3 and TR 3 TRADD interaction . ^^^ Mutation of charged residues in the second and third helices of the TR 3 death domain failed to perturb self interaction or interaction with TRADD . ^^^ These data suggest that despite some similarity between the death domains of TR 3 and TNFR 1 the nature of the interaction with TRADD differs from that reported for TNFR1 . . ^^^ |
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| Interacting proteins: Q93038 and Q15628 |
Pubmed |
SVM Score :0.0 |
| WSL 1 also interacts specifically with the TNFR 1 associated molecule TRADD . ^^^ |
|
| Interacting proteins: Q93038 and Q15628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q93038 and Q15628 |
Pubmed |
SVM Score :0.0 |
| NA |
|