| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| DR 3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD , TRAF 2 , FADD , and FLICE . ^^^ |
|
| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In a second step , TRADD and RIP 1 associate with FADD and caspase 8 , forming a cytoplasmic complex ( complex 2 ) . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Multiplex RT PCR was used to analyze FLICE , FAS , FADD and TRADD mRNAs before and after CD 40 triggering . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Using the ribonuclease ( RNase ) protection assay and the reverse transcriptase polymerase chain reaction ( RT PCR ) method , we confirmed that TNF receptor 1 ( TNFR 1 ) , TNFR 1 associated death domain protein ( TRADD ) , Fas receptor associated intracellular protein with death domain ( FADD ) , and FADD like interleukin 1beta converting enzyme ( FLICE ) were expressed in the pancreatic beta cell line , MIN 6 cells . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The most well known apoptotic pathway regulated by TNF involves the TNFR 1 associated death domain protein , Fas associated death domain protein , and caspase 8 . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The flow of death signals from TNFR 1 occurs through the adaptor molecule tumor necrosis factor receptor associated death domain protein ( TRADD ) to FADD to FLICE , whereas for CD 95 the receptor directly communicates with FADD and then FLICE . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Consistent with the inhibition of caspase 8 , ARC attenuated apoptosis induced by FADD and TRADD and that triggered by stimulation of death receptors coupled to caspase 8 , including CD95 / Fas , tumor necrosis factor R 1 , and TRAMP / DR3 . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| A mutant of Casper and the caspase specific inhibitors crmA and BD fmk partially inhibit TNF R 1 , TRADD , and TNF induced NF kappaB activation , suggesting that FADD , Casper , and caspase 8 function downstream of TRADD and contribute to TNF R 1 induced NF kappaB activation . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Transcriptional expression of TNFR 1 ( p 55 ) , as well as that of FLICE , Fas , FADD , DR 3 , FAF , TRADD , and RIP was similar in these cell lines , indicating that the susceptibility to TNFalpha induced apoptosis may not be determined by the constitutive expression level of these factors . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Two transduction events , the receptor recruitment of the adapter protein , TRADD , and the activation of the initiator caspase , caspase 8 , were investigated . ^^^ In combination with TNF alpha , however , ceramide potentiated , whereas NO inhibited , TNF alpha induced TRADD recruitment and caspase 8 activity . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Death receptors belong to the TNF receptor family and are characterised by an intracellular death domain that serves to recruit adapter proteins such as TRADD and FADD and cysteine proteases such as Caspase 8 . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The C terminal fragment of RIP also enhanced the association between TNFR 1 and death domain proteins including TNFR 1 associated death domain ( TRADD ) and Fas associated death domain ( FADD ) , resulting in the activation of caspase 8 and stimulation of apoptosis . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| To detect the expression of apoptosis related molecules , ribonuclease protection assay was used with specific antisense RNA probes for Fas , Fas ligand , TNFR 1 , TRAIL , FADD , TRADD , RIP , FAF , FAP , and caspase 8 . ^^^ Immunostaining for Fas , Fas ligand , TRAIL , TRADD , RIP , and caspase 8 was also performed . ^^^ Compared with control and contralateral kidneys , the ligated kidneys displayed a dynamic expression of mRNAs for many apoptosis related molecules , which included an up to threefold increase for Fas , Fas ligand , TNF R 1 , TRAIL , TRADD , RIP , and caspase 8 , and an up to twofold increase for FADD and FAP , but there was little change for FAF . ^^^ Although increased expression of TRAIL , TRADD , RIP , and caspase 8 was noted in tubular cells , there was no staining for these molecules in interstitial cells . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Under the conditions where HIPK2 / TRADD association was found , no direct interaction of HIPK 2 with CD 95 , TNF R 1 , FADD or caspase 8 could be detected . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The adaptor protein FADD directly , or indirectly via another adaptor called TRADD , recruits caspase 8 to death receptors of the tumor necrosis factor receptor family . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We also showed that overexpressed NH 2 termini of K 18 and K8 / 18 were associated with endogenous TRADD in SW 13 cells , resulting in the inhibition of caspase 8 activation . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Our data indicate that the resistance of p 53 mutated cl . 1001 cells to TNF induced cell death was not due to a defect in the expression of TRADD and FADD , yet correlated with a reduced caspase 8 activation as well as a deficient mitochondrial membrane permeabilization . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Blood and liver were analyzed for plasma aminotransferase activity , liver histology , liver apoptotic nuclei , mRNA of several cytokines ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 10 ) , apoptotic ligands ( TRAIL ) , cytokine receptors ( TNFRp 55 ) , pro and antiapoptotic regulators / adaptors ( Fas receptor , FasL , FADD , TRADD , RIP , Bak , Bax , Bcl 10 , Bcl 2 and Bcl w ) , and caspase 8 . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Thus in PC 12 pheochromocytoma cells , ceramide appears to amplify the death signal and there appears to be a sequence of events : TNF ; TRADD , pro caspase 8 , caspase 8 , sphingomyelinase , ceramide , caspase 3 , apoptosis . . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Analysis of the native TNF signaling complex revealed the recruitment of RIP , TRADD , and TRAF 2 but not FADD or caspase 8 . ^^^ In an in vitro binding assay , the intracellular domain of TNF R 1 bound TRADD , RIP , and TRAF 2 but did not bind FADD or caspase 8 . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| FB 1 did not alter CD 95 expression in either strain ; however , expressions of TRAIL , and downstream signaling factors FADD , TRADD , and caspase 8 were higher in FB 1 treated TKO mice than in the corresponding WT animals . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The recruitment of TRADD , FADD , and activation of caspase 8 and 3 in SM treated A 549 cells evidenced the activation of TNFRs signal transduction . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that within minutes internalized TNF R 1 ( TNF receptosomes ) recruits TRADD , FADD , and caspase 8 to establish the `` death inducing signaling complex ' ' ( DISC ) . ^^^ In contrast , aggregation of TRADD , FADD , and caspase 8 to establish the TNF R 1 associated DISC is critically dependent on receptor endocytosis . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In particular , the expression of procaspase 8 gene and subsequent cleavage of caspase 8 were markedly reduced in HL 60 / FAK cells , while expression of TRAIL receptor 2 and 3 , TRADD , and FADD was equivalent in both types of cells . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Moreover , we found that with progression of the disease process leading to neuronal cell death , an up regulation of genes involved in the TNF alpha death pathway caspase 8 , FADD , TNFRp 55 , TRADD , and RIP by an RNA protection assay . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| These cytokines induce cell death through sequential recruitment by the death receptors TNFR 1 associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , FADD like interleukin 1beta converting enzyme ( FLICE ) , and downstream caspases . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| This was established by showing that CIN 85 was co precipitated with TNFR 1 , TRADD , cIAP 1 and TARF1 / 2 , but not with FADD , RIP , caspase 8 or TRAF 6 . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Recruitment of TRADD , FADD , and caspase 8 to double stranded RNA triggered death inducing signaling complexes ( dsRNA DISCs ) . ^^^ DsRNA DISCs contain FADD , TRADD , and caspase 8 ; however , several experimental approaches suggest that death ligands and death receptors ( such as Fas / Apo1 and DR4 / Apo2 ) are not involved in the formation of dsRNA DISCs . . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Cytoplasmic TRADD activates apoptosis through Fas associated death domain protein ( FADD ) and caspase 8 activation that was blocked by caspase inhibitors or dominant negative FADD . ^^^ This pathway represents an alternate means by which TRADD can regulate cell death independently of FADD and caspase 8 that occurs from the nucleus rather than the cytoplasm . . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The analysed factors included TNF alpha , TNFR 1 , TNF receptor associated death domain ( TRADD ) , caspase 3 , caspase 8 , TNF receptor associated factor 2 ( TRAF 2 ) and receptor interactive protein ( RIP ) , all of which are involved in the TNF alpha / TNFR 1 signalling pathway mediated apoptosis . ^^^ The quantitative RT PCR indicated that the infected muscle tissues up regulate the expression of pro apoptosis genes ( TNF alpha , TNFR 1 and TRADD , caspase 3 and caspase 8 ) , and anti apoptosis genes ( TRAF 2 and RIP ) at the beginning of cyst formation . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Activation of the route from cell surface requires the cellular components that include membrane receptors , adaptor proteins such as TRADD and FADD , and caspase 8 , while activation of the other from mitochondria requires Apaf 1 , caspase 9 , and cytosolic cytochrome c . ^^^ |
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| Interacting proteins: Q15628 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The authors tried to determine the responsible molecules ; however , expression of TRAIL receptors ; pro caspase 3 / 8 / 9 ; Fas associated death domain protein ( FADD ) ; tumor necrosis factor receptor 1 associated death domain protein ( TRADD ) ; silencer of death domain ( SODD ) ; FLICE inhibitory protein ( FLIP ) ; and Bcl 2 , Bcl xL , and Bax in FLS was not modulated by IFN gamma . ^^^ |
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