| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.51568487 |
| Here we show that TRADD directly interacts with TRAF 2 and FADD , signal transducers that activate NF kappa B and induce apoptosis , respectively . 0.51568487^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.86661445 |
| Using the ribonuclease ( RNase ) protection assay and the reverse transcriptase polymerase chain reaction ( RT PCR ) method , we confirmed that TNF receptor 1 ( TNFR 1 ) , TNFR 1 associated death domain protein ( TRADD ) , Fas receptor associated intracellular protein with death domain ( FADD ) , and FADD like interleukin 1beta converting enzyme ( FLICE ) were expressed in the pancreatic beta cell line , MIN 6 cells . 0.86661445^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.51507772 |
| The FADD death domain binds to activated receptors such as Fas or other adapters such as TRADD , whereas the FADD death effector domain binds to procaspase 8 . 0.51507772^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| TNFR 1 signaling factors TRADD and Fas associated death domain protein ( FADD ) were also found to interact with Stat 1 in a TNF alpha dependent process . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The most well known apoptotic pathway regulated by TNF involves the TNFR 1 associated death domain protein , Fas associated death domain protein , and caspase 8 . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Cytoplasmic TRADD activates apoptosis through Fas associated death domain protein ( FADD ) and caspase 8 activation that was blocked by caspase inhibitors or dominant negative FADD . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The authors tried to determine the responsible molecules ; however , expression of TRAIL receptors ; pro caspase 3 / 8 / 9 ; Fas associated death domain protein ( FADD ) ; tumor necrosis factor receptor 1 associated death domain protein ( TRADD ) ; silencer of death domain ( SODD ) ; FLICE inhibitory protein ( FLIP ) ; and Bcl 2 , Bcl xL , and Bax in FLS was not modulated by IFN gamma . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The constitutive expression of mRNA for TNF alpha receptors ( TNFR 1 and TNFR 2 ) and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) , and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase PCR ( RT PCR ) in PBMCs from control and RA cases . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The adaptor protein FADD directly , or indirectly via another adaptor called TRADD , recruits caspase 8 to death receptors of the tumor necrosis factor receptor family . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| One , MORT 1 ( also called FADD ) , binds to Fas / APO1 but not to p 55 R ; another , TRADD , binds to the p 55 TNF receptor but not to Fas / APO1 ; and the third , RIP , binds weakly to both receptors . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Upon activation of these receptors , Fas / APO 1 binds a protein called MORT 1 ( or FADD ) and p 55 R binds a protein called TRADD . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| DR 3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD , TRAF 2 , FADD , and FLICE . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Interaction of the p 55 tumor necrosis factor receptor 1 ( TNF R 1 ) associated signal transducer TRADD with FADD signals apoptosis , whereas the TNF receptor associated factor 2 protein ( TRAF 2 ) is required for activation of the nuclear transcription factor nuclear factor kappa B . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The constitutive expression of mRNA for TNF receptors ( TNFR ) , including TNFRI and TNFRII , and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase ( RT ) PCR in bone marrow samples from control , MDS and AML cases . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| We investigated hepatitis B virus ( HBV ) DNA integration and expression of several proteins involved in the cell cycle and apoptosis , including cyclin A , retinoblastoma protein ( pRB ) , Fas associated death domain protein ( FADD ) , tumor necrosis factor receptor associated death domain protein ( TRADD ) , and nuclear factor kappaB ( NF kappaB ) in HBV associated hepatocellular carcinoma ( HCC ) and liver cirrhosis ( LC ) . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| These cytokines induce cell death through sequential recruitment by the death receptors TNFR 1 associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , FADD like interleukin 1beta converting enzyme ( FLICE ) , and downstream caspases . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The flow of death signals from TNFR 1 occurs through the adaptor molecule tumor necrosis factor receptor associated death domain protein ( TRADD ) to FADD to FLICE , whereas for CD 95 the receptor directly communicates with FADD and then FLICE . ^^^ MC 159 and E 8 inhibited both TNFR 1 and CD 95 induced apoptosis as well as killing mediated by overexpression of the downstream adaptors TRADD and FADD . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Fas / Apo1 and other cytotoxic receptors of the tumor necrosis factor receptor ( TNFR ) family contain a cytoplasmic death domain ( DD ) [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ] [ 10 ] [ 11 ] that activates the apoptotic process by interacting with the DD containing adaptor proteins TNFR associated DD protein ( TRADD ) [ 12 ] [ 13 ] and Fas associated DD protein ( FADD / MORT1 ) [ 14 ] [ 15 ] , leading to the activation of cysteine proteases of the caspase family [ 16 ] . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| However , contrary to the previous reports , both DR 4 and DR 5 induced apoptosis can be blocked by dominant negative FADD , and both receptors can activate NF kappaB using a TRADD dependent pathway . ^^^ Finally , both receptors can interact with FADD , TRADD , and RIP . ^^^ Thus , both DR 5 and DR 4 use FADD , TRADD , and RIP in their signal transduction pathways , and FADD is the common mediator of apoptosis by all known death domain containing receptors . . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Both TRAIL receptors bind the adaptor molecules FADD and TRADD , and both death signals are interrupted by a dominant negative form of FADD and by the FLICE inhibitory protein FLIP . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| TNF receptor death domain associated proteins TRADD and FADD signal activation of acid sphingomyelinase . ^^^ Here we describe the TNF dependent activation of acid SMase ( A SMase ) through the p 55 TNF receptor associated proteins TRADD and FADD . ^^^ Overexpression of TRADD and FADD in 293 cells did not change basal activity of A SMase but enhanced TNF induced stimulation of A SMase . ^^^ Caspase inhibitors markedly reduced A SMase activity , suggesting the involvement of an ICE like protease in TRADD / FADD mediated activation of A SMase . ^^^ Overexpression of caspase 8 / a ( FLICE / MACH ) or caspase 10 / b ( FLICE 2 ) did not change A SMase activity , suggesting that TRADD / FADD mediated activation of A SMase involves a yet to be defined caspase like protease distinct from caspase 8 / a or 10 / b . . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| In their cytoplasmic region , some of these receptors share a conserved sequence motif the ' death domain ' which is required for transduction of the apoptotic signal by recruiting other death domain containing adaptor molecules like the Fas associated protein FADD / MORT1 or the TNF receptor associated protein TRADD [ 2 4 ] . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Consistent with the inhibition of caspase 8 , ARC attenuated apoptosis induced by FADD and TRADD and that triggered by stimulation of death receptors coupled to caspase 8 , including CD95 / Fas , tumor necrosis factor R 1 , and TRAMP / DR3 . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Notably , the two pro apoptotic adapter proteins TRADD and FADD are also involved in the activation of A SMase . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Members of the tumor necrosis factor receptor superfamily induce apoptosis via interaction with FADD and regulate cell growth and differentiation through TRADD and TRAFs molecules . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| A mutant of Casper and the caspase specific inhibitors crmA and BD fmk partially inhibit TNF R 1 , TRADD , and TNF induced NF kappaB activation , suggesting that FADD , Casper , and caspase 8 function downstream of TRADD and contribute to TNF R 1 induced NF kappaB activation . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Transcriptional expression of TNFR 1 ( p 55 ) , as well as that of FLICE , Fas , FADD , DR 3 , FAF , TRADD , and RIP was similar in these cell lines , indicating that the susceptibility to TNFalpha induced apoptosis may not be determined by the constitutive expression level of these factors . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Death receptors belong to the TNF receptor family and are characterised by an intracellular death domain that serves to recruit adapter proteins such as TRADD and FADD and cysteine proteases such as Caspase 8 . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Fas binds FADD directly , whereas TNFR 1 binds FADD indirectly , through TRADD . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The C terminal of TRADD comprises the `` death domain ' ' that is responsible for association of TNFR 1 and other death domain containing proteins such as FADD and RIP . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| FADD DD provides the site of FADD recruitment to death receptor complexes at the plasma membrane by , for example , interaction with the Fas receptor cytoplasmic death domain ( Fas DD ) , or binding of the TNF R 1 adapter molecule TRADD . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The C terminal fragment of RIP also enhanced the association between TNFR 1 and death domain proteins including TNFR 1 associated death domain ( TRADD ) and Fas associated death domain ( FADD ) , resulting in the activation of caspase 8 and stimulation of apoptosis . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| On the other hand , bcl 2 or certain novel proteins ( including FADD , RIP , TRADD and sentrin ) prevent apoptosis . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| TIAF 1 inhibits the cytotoxic effects of TNF alpha and overexpressed TNF receptor adaptors TRADD , FADD , and RIP . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The tumor necrosis factor receptor 1 ( TNFR 1 ) and the Fas receptor recruit complexes formed by the interactions between RIP kinase , TRADD , FADD and RAIDD adaptor proteins that contain death domains which in turn recruit other proteins to initiate signaling [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Although EDAR possesses a death domain , it did not interact with the death domain containing adaptor proteins TRADD and FADD . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Our aim was to expand these searches by looking for mutations in the death domains of FAS , FADD , TNFR , TRADD , and RIP , in the promoter region of FAS , and in the protease domain of caspase 10 , in a larger variety of hematological malignancies , some of which express an apoptosis resistant phenotype . ^^^ CONCLUSIONS : These observations imply that mutations in the death domains of FAS , FADD , TNFR , TRADD , and RIP and in the protease domain of caspase 10 are not a major cause for failure of apoptosis in hematological malignancies , mainly CML and CLL . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The expression of adapter molecules TNF receptor associated death domain ( TRADD ) , Fas associated death domain ( FADD ) and TNF associated factor 2 ( TRAF 2 ) and caspase 3 was analyzed by Western blotting . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor alpha ( TNF alpha ) induced activation of MAPKs has been shown to involve the death domain proteins ( TRADD , FADD , MADD ) and TRAFs . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Hepatitis C virus core protein enhances FADD mediated apoptosis and suppresses TRADD signaling of tumor necrosis factor receptor . ^^^ In this study , we further examined the interaction of the core protein with the signaling molecules of TNFR 1 , including FADD , TRADD , and TRAF 2 , in a human embryonic kidney cell line , HEK 293 , that overexpresses the HCV core protein . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| We found that blocking the TRADD mediated pathway using a dominant negative mutant of FADD ( FADD DN ) enhanced radiation resistance of GM cells , as reflected in both susceptibility to apoptosis and clonogenic survival following irradiation . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| These families may include receptor / ligand molecules such as Fas , Fas ligand , tumor necrosis factor receptor 1 ( TNFR 1 ) , and TNF related apoptosis inducing ligand ( TRAIL ) ; signal transduction adapter molecules such as Fas associated death domain ( FADD ) , TNFR 1 associated death domain ( TRADD ) , receptor interacting protein ( RIP ) , Fas associated factor ( FAF ) , and Fas associated phosphatase ( FAP ) ; or effector molecules such as caspases . ^^^ To detect the expression of apoptosis related molecules , ribonuclease protection assay was used with specific antisense RNA probes for Fas , Fas ligand , TNFR 1 , TRAIL , FADD , TRADD , RIP , FAF , FAP , and caspase 8 . ^^^ Compared with control and contralateral kidneys , the ligated kidneys displayed a dynamic expression of mRNAs for many apoptosis related molecules , which included an up to threefold increase for Fas , Fas ligand , TNF R 1 , TRAIL , TRADD , RIP , and caspase 8 , and an up to twofold increase for FADD and FAP , but there was little change for FAF . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Under the conditions where HIPK2 / TRADD association was found , no direct interaction of HIPK 2 with CD 95 , TNF R 1 , FADD or caspase 8 could be detected . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Furthermore , NS5A prevented the association between TRADD and FADD and blocked TRADD mediated NF kappaB activation . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Our data indicate that the resistance of p 53 mutated cl . 1001 cells to TNF induced cell death was not due to a defect in the expression of TRADD and FADD , yet correlated with a reduced caspase 8 activation as well as a deficient mitochondrial membrane permeabilization . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Apoptosis by nuclear TRADD DD is promyelocytic leukemia protein dependent , involves p 53 , and is inhibited by Bcl xL but not by caspase inhibitors or dominant negative FADD ( FADD DN ) . ^^^ Conversely , apoptosis induced by TRADD in the cytoplasm is resistant to Bcl xL , but sensitive to caspase inhibitors and FADD DN . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Blood and liver were analyzed for plasma aminotransferase activity , liver histology , liver apoptotic nuclei , mRNA of several cytokines ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 10 ) , apoptotic ligands ( TRAIL ) , cytokine receptors ( TNFRp 55 ) , pro and antiapoptotic regulators / adaptors ( Fas receptor , FasL , FADD , TRADD , RIP , Bak , Bax , Bcl 10 , Bcl 2 and Bcl w ) , and caspase 8 . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Furthermore , IL 12 induced apoptosis was associated with caspase 3 , caspase 2 , caspase 7 , DNA fragmentation factor 45 ( DFF 45 ) and Fas associated death domain ( FADD ) whereas TNF receptor associated death domain ( TRADD ) and receptor interacting protein ( RIP ) were not . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| CD 95 , TNF related apoptosis inducing ligand ( TRAIL R 1 ) , and TRAIL R 2 bind FADD directly , whereas recruitment to TNF R 1 is indirect through another adaptor TNF receptor associated death domain protein ( TRADD ) . ^^^ Analysis of the native TNF signaling complex revealed the recruitment of RIP , TRADD , and TRAF 2 but not FADD or caspase 8 . ^^^ In an in vitro binding assay , the intracellular domain of TNF R 1 bound TRADD , RIP , and TRAF 2 but did not bind FADD or caspase 8 . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Expression of TNF receptor 55 and TNF receptor associated death domain ( TRADD ) was increased , with no changes in Fas signaling molecules , Fas , Fas ligand ( FasL ) , Fas associated death domain ( FADD ) and Fas associated protein factor ( FAF ) . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| RESULTS : ACEI resulted in a significant induction of Fas , FADD , and TRADD mRNAs in renal transplant patients with or without PTE . ^^^ ACEI also resulted in a significant upregulation of Fas , FADD and TRADD protein expression , and their localization predominantly at the plasma membrane . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| While recruitment of death domain ( DD ) containing adaptors such as Fas associated death domain ( FADD ) and TNFR associated DD ( TRADD ) can lead to the activation of a signal transduction pathway that induces apoptosis , recruitment of TRAF family proteins can lead to the activation of transcription factors such as , NF kappaB and JNK thereby promoting cell survival and differentiation as well as immune and inflammatory responses . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The first complex ( complex 1 ) is formed at the membrane by TNF R 1 , TRADD , RIP , TRAF 2 and c IAP 1 , while the second complex ( complex 2 ) , formed in the cytosol , predominantly contains FADD and pro caspases 8 / 10 but lacks TNF R 1 . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The expression patterns of pro apoptotic genes ( Fas , FasL , TRADD , FADD ) and caspases 2 , 3 , 8 , 9 were studied using PCR . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| FB 1 did not alter CD 95 expression in either strain ; however , expressions of TRAIL , and downstream signaling factors FADD , TRADD , and caspase 8 were higher in FB 1 treated TKO mice than in the corresponding WT animals . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Moreover , using the yeast two hybrid system , we tested whether p75NTR intracellular domain was able to dimerize or interact with known DD containing proteins including FADD , RIP , RAIDD and TRADD . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Multiplex RT PCR was used to analyze FLICE , FAS , FADD and TRADD mRNAs before and after CD 40 triggering . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Although XEDAR induced apoptosis can be blocked by dominant negative Fas associated death domain ( FADD ) protein and FADD small interfering RNA , XEDAR does not directly bind to FADD , tumor necrosis factor receptor associated death domain ( TRADD ) protein , or RIP 1 . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The recruitment of TRADD , FADD , and activation of caspase 8 and 3 in SM treated A 549 cells evidenced the activation of TNFRs signal transduction . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that within minutes internalized TNF R 1 ( TNF receptosomes ) recruits TRADD , FADD , and caspase 8 to establish the `` death inducing signaling complex ' ' ( DISC ) . ^^^ In contrast , aggregation of TRADD , FADD , and caspase 8 to establish the TNF R 1 associated DISC is critically dependent on receptor endocytosis . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| In particular , the expression of procaspase 8 gene and subsequent cleavage of caspase 8 were markedly reduced in HL 60 / FAK cells , while expression of TRAIL receptor 2 and 3 , TRADD , and FADD was equivalent in both types of cells . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| In a second step , TRADD and RIP 1 associate with FADD and caspase 8 , forming a cytoplasmic complex ( complex 2 ) . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| IL 8 induced NF kappaB activation is for the most part unaltered when cells are transfected with dominant negative TRADD , FADD , or TRAF 2 , but is inhibited with dominant negative TRAF 6 , NIK , IKK , or IkappaBalpha transfected cells . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| In contrast , transiently expressed Zfra could enhance or inhibit the cytotoxicity of overexpressed death domain proteins TRADD , FADD , and RIP of the TNF signaling pathway . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The high expression level of SODD or of dominant negative forms of FADD ( FADD DN ) and DAP 3 ( DAP 3 DN ) , or of NH 2 terminal deletion mutant of TRADD ( TRADD ND ) achieved by transient transfection experiments , did not impair the kinetics of apoptosis after camptothecin and VP 16 treatment in HL 60 and U 937 cells . ^^^ Taken together , these observations suggested that camptothecin and VP 16 induced rapid aggregation of DR 4 and DR 3 , but paradoxically , the importance of these events in signaling apoptosis is uncertain , because the kinetics of apoptosis were unaffected , even in the presence of a high expression level of SODD , FADD DN , TRADD ND , and DAP 3 DN . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Moreover , we found that with progression of the disease process leading to neuronal cell death , an up regulation of genes involved in the TNF alpha death pathway caspase 8 , FADD , TNFRp 55 , TRADD , and RIP by an RNA protection assay . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| This was established by showing that CIN 85 was co precipitated with TNFR 1 , TRADD , cIAP 1 and TARF1 / 2 , but not with FADD , RIP , caspase 8 or TRAF 6 . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Recruitment of TRADD , FADD , and caspase 8 to double stranded RNA triggered death inducing signaling complexes ( dsRNA DISCs ) . ^^^ DsRNA DISCs contain FADD , TRADD , and caspase 8 ; however , several experimental approaches suggest that death ligands and death receptors ( such as Fas / Apo1 and DR4 / Apo2 ) are not involved in the formation of dsRNA DISCs . . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Members of the TNFR family lack intrinsic kinase activity and thus they initiate signaling by interacting intracellular signaling molecules such as TNFR associated factor ( TRAF ) , TNFR associated death domain ( TRADD ) and Fas associated death domain ( FADD ) . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| AIM : To evaluate the expressions of apoptotic signal proteins FADD , TRADD , FasL , Fas , and NFkappaB in gastric carcinoma tissues and their clinical significance . ^^^ METHODS : Western blot immune trace method was adopted to detect the expressions of apoptotic signal proteins FADD , TRADD , FasL , Fas , and NFkappaB in 55 tissue specimens of gastric carcinoma . ^^^ Expressions of the FADD , FasL , Fas , and NFkappaB proteins reduced with increase of the volume of tumor with the exception of increased expression the TRADD protein ( 64 . 7 71 . 1 % , P = 0 . 031 ) . ^^^ With gradual increase of the malignancy of gastric carcinoma tissues , expressions of the FADD , FasL , and Fas proteins decreased ( 78 . 6 28 . 0 % , P = 0 . 008 ; 78 . 6 65 . 9 % , P = 0 . 071 ; 100 . 0 46 . 3 % , P = 0 . 014 ) , while expressions of the TRADD and NFkappaB proteins increased ( 42 . 9 78 . 1 % , P = 0 . 063 ; 78 . 6 79 . 1 % , P = 0 . 134 ) . ^^^ With gradual increase of serum CEA , expression of the FADD protein decreased ( 62 . 5 34 . 0 % , P = 0 . 073 ) , but expressions of the TRADD , FasL , Fas , and NFkappaB proteins increased ( 0 . 0 80 . 8 % , P = 0 . 005 ; 62 . 5 70 . 2 % , P = 0 . 093 ; 0 . 0 70 . 2 % , P = 0 . 003 ; 62 . 5 80 . 9 % , P = 0 . 075 ) . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| A coimmunoprecipitation assay also suggested that HCV core protein does not interfere with the TRADD Fas associated death domain protein ( FADD ) procaspase 8 interaction . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| The mechanism by which these domains engage their binding partners has been explored by extensive mutagenesis of two death adaptors , FADD and TRADD , suggesting that a death adaptor can discriminate its intended binding partners from other proteins harboring similar motifs . ^^^ Comparing the topology of protein protein interactions for FADD complexes to TRADD complexes reveals that FADD uses a Tube like surface in each of its death motifs to engage either CD 95 or TRADD . ^^^ TRADD reverses these roles , employing a Pelle like surface to interact with either receptor TNFR 1 or adaptor FADD . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Some members of the DR family , CD 95 and the TRAIL receptors DR 4 and DR 5 , directly bind FADD , whereas others , such as TNF receptor 1 and DR 3 , initially bind another adaptor protein , TRADD , which then recruits FADD . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Activation of the route from cell surface requires the cellular components that include membrane receptors , adaptor proteins such as TRADD and FADD , and caspase 8 , while activation of the other from mitochondria requires Apaf 1 , caspase 9 , and cytosolic cytochrome c . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Hepatic mRNA levels were measured for several pro apoptotic adaptors / regulators , including FasL , Fas receptor , FADD , TRADD , Bad , Bak , Bax , and Bcl 10 ( S ) , and anti apoptotic regulators , including Bcl w , Bcl 10 ( L ) , Bcl 2 , and Bfl 1 . ^^^ |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q15628 |
Pubmed |
SVM Score :0.0 |
| NA |
|