| Interacting proteins: P16615 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Fas / Apo1 and other cytotoxic receptors of the tumor necrosis factor receptor ( TNFR ) family contain a cytoplasmic death domain ( DD ) [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] [ 6 ] [ 7 ] [ 8 ] [ 9 ] [ 10 ] [ 11 ] that activates the apoptotic process by interacting with the DD containing adaptor proteins TNFR associated DD protein ( TRADD ) [ 12 ] [ 13 ] and Fas associated DD protein ( FADD / MORT1 ) [ 14 ] [ 15 ] , leading to the activation of cysteine proteases of the caspase family [ 16 ] . ^^^ |
|
| Interacting proteins: P16615 and Q15628 |
Pubmed |
SVM Score :0.0 |
| TNFR 1 recruits and assembles a signaling complex containing a number of death domain ( DD ) containing proteins , including the adaptor protein TRADD and the serine / threonine kinase RIP , which mediates TNF induced NF kappa B activation . ^^^ |
|
| Interacting proteins: P16615 and Q15628 |
Pubmed |
SVM Score :0.0 |
| These results provide important insight into the molecular interactions mediating TNFR DD self association and subsequent recruitment of TRADD in the signaling activity of TNFR 1 . . ^^^ |
|
| Interacting proteins: P16615 and Q15628 |
Pubmed |
SVM Score :0.0 |
| FADD DD provides the site of FADD recruitment to death receptor complexes at the plasma membrane by , for example , interaction with the Fas receptor cytoplasmic death domain ( Fas DD ) , or binding of the TNF R 1 adapter molecule TRADD . ^^^ |
|
| Interacting proteins: P16615 and Q15628 |
Pubmed |
SVM Score :0.0 |
| In contrast , the core protein did not directly interact with the DD of TRADD , but could disrupt the binding of TRADD to TNFR 1 . ^^^ |
|
| Interacting proteins: P16615 and Q15628 |
Pubmed |
SVM Score :0.0 |
| While recruitment of death domain ( DD ) containing adaptors such as Fas associated death domain ( FADD ) and TNFR associated DD ( TRADD ) can lead to the activation of a signal transduction pathway that induces apoptosis , recruitment of TRAF family proteins can lead to the activation of transcription factors such as , NF kappaB and JNK thereby promoting cell survival and differentiation as well as immune and inflammatory responses . ^^^ |
|
| Interacting proteins: P16615 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Moreover , using the yeast two hybrid system , we tested whether p75NTR intracellular domain was able to dimerize or interact with known DD containing proteins including FADD , RIP , RAIDD and TRADD . ^^^ |
|
| Interacting proteins: P16615 and Q15628 |
Pubmed |
SVM Score :0.0 |
| Modeling of six homotypic DD interactions involved in the TNF signaling pathway implicates that the DD of RIP ( Receptor interacting protein kinase 1 ) is capable of interacting with the DD of TRADD ( TNFR 1 associated death domain protein ) in two different , exclusive ways : one that subsequently recruits CRADD ( apoptosis / inflammation ) and another that recruits NFkappaB ( survival / proliferation ) . . ^^^ |
|
| Interacting proteins: P16615 and Q15628 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16615 and Q15628 |
Pubmed |
SVM Score :0.0 |
| NA |
|