| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Neointima formation and TGF beta 1 immunoreactivity were correlated with increases in fibronectin , collagen alpha 2 ( 1 ) , and collagen alpha 1 ( 3 ) gene expression . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| The effect of TGF beta 1 on the expression of the basement membrane genes , fibronectin , laminin B 1 , and collagen alpha 1 ( 4 ) , was examined . ^^^ Treatment of these differentiated cells with TGF beta 1 induced the expression of fibronectin mRNA to levels seen in TGF beta treated , undifferentiated keratinocytes but only marginally increased the expression of collagen alpha 1 ( 4 ) and laminin B 1 mRNA . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| RNA was isolated after the addition of varying amounts of TGF beta 1 to the cells in culture for varying periods of time , and collagen alpha 1 ( 4 ) RNA was quantitated by filter hybridization . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| TGF beta 1 increased steady state lysyl oxidase and COL1A1 mRNA levels in a dose and time dependent manner . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Brief stimulation with of TGF beta 1 upregulated the COL1A1 gene transcription in fetal fibroblasts . ^^^ CONCLUSION : COL1A1 gene expression is notably absent in unstimulated fetal fibroblasts , but is upregulated by TGF beta 1 . ^^^ In contrast , postnatal fibroblasts demonstrate significant constitutive COL1A1 gene expression at baseline and unchanged after TGF beta 1 stimulation . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Dose dependent induction by TGF beta 1 was observed for both HSP 47 mRNA and collagen alpha 1 ( 1 ) mRNA , and actinomycin D inhibited this increase of HSP 47 mRNA . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Elevated expression of collagen alpha 1 ( 3 ) chain and TGF beta 1 mRNAs , and its reversal by saralasin were also demonstrated in stretched SMCs . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| PTX also suppressed both basal and TGF beta 1 augmented collagen alpha 1 ( 1 ) and collagen alpha 1 ( 3 ) mRNA levels beginning at 24 h , and attenuated both basal and TGF beta 1 ( 5 ng / ml ) stimulated total collagen synthesis at 48 h . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Bacterial cell wall polymers directly stimulated collagen alpha 1 ( 1 ) , TGF beta 1 , IL 1beta , and IL 6 mRNA expression in the intestinal myofibroblasts derived from both normal and inflamed cecum . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Significant increases in mRNA for fibronectin ( 7 . 5 fold , P < 0 . 01 ) , heparan sulfate proteoglycan core protein ( 53 fold , P < 0 . 001 ) , laminin beta 1 ( 12 fold , P < 0 . 001 ) , collagen alpha 1 ( 4 ) ( 17 fold , P < 0 . 001 ) , collagen alpha 1 ( 3 ) ( fourfold , P < 0 . 001 ) , and MMP 9 ( twofold , P < 0 . 05 ) were observed after perfusion with TGF beta 1 . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The mRNAs encoding TGF beta 1 ( in both mouse and human ) , entactin , fibronectin , and the collagen alpha 1 ( 4 ) and alpha 2 ( 4 ) chains were significantly induced in total kidney as a function of Alport renal disease progression . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Although this element overlaps to a previously described transforming growth factor beta 1 ( TGF beta 1 ) responsive element , the stimulatory effect of acetaldehyde is not mediated through this cytokine , because addition of neutralizing anti TGF beta 1 antibodies does not prevent acetaldehyde elicited col1a1 up regulation . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| We have investigated the possible association between BMD and two polymorphisms in 135 beta thalassaemic patients : ( 1 ) a substitution G > Tau in a regulatory region of the COLIA 1 gene encoding for the major protein of bone ( type 1 collagen ) , and ( 2 ) a one base deletion in intron 4 ( 713 8del C ) of transforming growth factor beta 1 ( TGF beta 1 ) gene . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Cellular ANG , TGF beta 1 , and collagen alpha 1 ( type 4 ) mRNA levels were determined by Northern blot analysis or by reverse transcriptase PCR assay . ^^^ The results showed that stable transfer of antisense ANG cDNA into IRPTC suppressed the basal TGF beta 1 and collagen alpha 1 ( type 4 ) mRNA expression and blocked the stimulatory effect of high glucose ( i . e . , 25 mM ) on TGF beta 1 and collagen alpha 1 ( type 4 ) mRNA expression and induction of IRPTC hypertrophy . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Renal cortical mRNA levels of TGF beta 1 , collagen alpha 1 ( 4 ) , collagen alpha 1 ( 1 ) , decorin , and the household gene glyceraldehyde 3 phosphate dehydrogenase in biopsy specimens taken during acute rejection episodes were quantified by real time polymerase chain reaction . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| This study compared the association of OSF and polymorphisms of six collagen related genes , collagen 1A1 and 1A2 ( COL1A1 and COL1A2 ) , collagenase 1 ( COLase ) , transforming growth factor beta 1 ( TGF beta 1 ) , lysyl oxidase ( LYOXase ) , and cystatin C ( CST 3 ) , between patients with low and high exposure to betel quids . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| In cells lacking Sp 1 and KLF 6 , transfected KLF 6 and Sp 1 cooperatively transactivated the endoglin promoter and those of collagen alpha 1 ( 1 ) , urokinase type plasminogen activator , TGF beta 1 , and TGF beta receptor type 1 . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| The activation of primary and immortalized human stellate cells after incubation with apoptotic bodies , as well as their fibrogenic activity , was indicated by an increase in alpha smooth muscle actin ( primary cells ) , TGF beta 1 , and collagen alpha 1 ( 1 ) mRNA ( primary and immortalized cells ) . ^^^ The profibrogenic response was dependent upon apoptotic body engulfment , because nocodazole , a microtubule inhibiting agent , blocked both the engulfment and the increase of TGF beta 1 and collagen alpha 1 ( 1 ) mRNA . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Liver hydroxyproline content , the mRNA expression of collagen alpha 1 ( 1 ) and alpha smooth muscle actin ( alpha SMA ) , and plasma levels of transforming growth factor beta 1 ( TGF beta 1 ) were significantly reduced by olmesartan treatment , suggesting that olmesartan improved liver fibrosis . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Tests of linkage and / or association of TGF beta 1 and COL1A1 genes with bone mass . ^^^ Transforming growth factor beta 1 ( TGF beta 1 ) is involved in bone metabolism and collagen type 1 alpha 1 ( COL1A1 ) is the most abundant protein of bone matrix . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| The effect of NS 398 , a selective COX 2 inhibitor , and PGE ( 2 ) on TGF beta 1 mediated fibrogenesis was examined by measuring mRNA levels of collagen alpha 1 ( 1 ) . ^^^ Importantly , TGF beta 1 mediated induction of collagen alpha 1 ( 1 ) was markedly suppressed by the addition of exogenous PGE ( 2 ) . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| These genes encode for transcription factors ( EGR 1 and FOS ) , growth factors or related proteins ( CTGF , CYR 61 , CX3CL1 , TGFB 1 , and PDGFRA ) , and extracellular matrix protein ( COL1A1 ) . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Low oxygen tension stimulates collagen synthesis and COL1A1 transcription through the action of TGF beta 1 . ^^^ We have previously shown that hypoxia ( 2 % O 2 ) , when compared to standard oxygen tension ( 20 % O 2 ) , upregulates the mRNA levels of the human alpha 1 ( 1 ) ( COL1A1 ) procollagen gene and transforming growth factor beta 1 ( TGF beta 1 ) in human dermal fibroblasts . ^^^ Upregulation of COL1A1 mRNA levels in hypoxia was blocked by a TGF beta 1 anti sense oligonucleotide , and failed to occur in fibroblasts from TGF beta 1 knock out mice . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Polymorphisms of the following genes were investigated : OPG , VDR , ESR 1 , TGFB 1 COL1A1 , and BMP 2 . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Messenger ribonucleic acid transcripts for both the COL1A1 and COL3A1 genes were elevated at 4 , 6 , and 24 hours in TGF beta 1 treated cultures , preceding the expression of the collagenous protein , showing that TGF beta 1 effects on bladder smooth muscle occur , at least in part , at the transcriptional level . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| The stimulation of Mo with MCP 1 increased mRNA levels of TGF beta 1 and a pro alpha 1 chain of type 1 collagen ( COL1A1 ) as well as protein synthesis . ^^^ It was also noted that pretreatment with TGF beta 1 specific AS ODN partially reduced COL1A1 mRNA levels . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Seventeen days after UUO , significant increases in collagen alpha 2 ( 1 ) , collagen alpha 1 ( 4 ) , TGF beta 1 and endoglin mRNA levels were detected in L kidneys vs NL kidneys . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| RT PCR revealed that alpha MSH gene therapy attenuated the liver TGF beta 1 , collagen alpha 1 , and cell adhesion molecule mRNA upregulation . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| RT PCR revealed that IL 10 gene therapy attenuated liver TGF beta 1 , collagen alpha 1 , fibronectin , and cell adhesion molecule mRNA upregulation . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Levels of collagen alpha 1 gene expression , hydroxyproline , angiotensin 2 and TGF beta 1 proteins , and TGF beta 1 mRNA were measured on the colonic tissue . ^^^ RESULTS : In chronic colitis , captopril significantly reduced the score of macroscopic and histologic lesions , as well as the colonic tissue levels of collagen alpha 1 , hydroxyproline , ANG 2 and TGF beta 1 proteins , and TGF beta 1 mRNA . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| V . injections of a double stranded oligodeoxynucleotide decoy containing the TGF beta regulatory element found in the distal promoter of the COL1A1 gene into worm infected mice suppressed TGF beta 1 , COL1A1 , tissue inhibitor of metalloproteinase 1 , and decreased COL3A1 mRNAs to a lesser extent . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| Both Bleomycin and TGF beta 1 increase the transcription of the COL1A1 gene . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The mRNA expressions of collagen alpha 1 ( 1 ) , MMP 1 , TIMP 1 , TGF beta 1 were not changed by 17beta estradiol stimulations at a concentration of 10 ( 12 ) to 10 ( 8 ) M . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| METHODS : We analysed the collagen content in terminal failing ventricles of VAD patients and donor hearts using 4 hydroxyproline for total collagen and real time RT PCR for fibronectin ( FN ) , collagen 1 alpha 1 ( Col1A1 ) , 3 alpha 1 ( Col3A1 ) and TGF beta 1 analysis . ^^^ RESULTS : Compared to donor hearts we found similar increases in Col1A1 and TGF beta 1 but not Col3A1 and FN mRNAs , which were similar in the myocardium from patients receiving a VAD or heart transplant . ^^^ |
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| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| We also examined the effects of IL 7 , PKC inhibitor , and STAT inhibitor on the expressions of TGF beta 1 and type 1 collagen alpha 1 chain ( col1A1 ) m RNA by using real time RT PCR . ^^^ Each of IL 7 , BIS 1 , or AGS 490 reduced the mRNA expressions of TGF beta 1 and col1A1 . ^^^ |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15582 and P02452 |
Pubmed |
SVM Score :0.0 |
| NA |
|