| Interacting proteins: Q15464 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of LAT creates binding sites for the Src homology 2 ( SH 2 ) domains of other proteins , including PLC gamma 1 , Grb 2 , Gads , Grap , 3BP2 , and Shb , and indirectly binds SOS , c Cbl , Vav , SLP 76 , and Itk . ^^^ |
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| Interacting proteins: Q15464 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Shb links SLP 76 and Vav with the CD 3 complex in Jurkat T cells . ^^^ This study addresses the interactions between the adaptor protein Shb and components involved in T cell signalling , including SLP 76 , Gads , Vav and ZAP 70 . ^^^ We show that both SLP 76 and ZAP 70 co immunoprecipitate with Shb in Jurkat T cells and that Shb and Vav co immunoprecipitate when cotransfected in COS cells . ^^^ We also demonstrate , utilizing fusion protein constructs , that SLP 76 , Gads and Vav associate independently of each other to different domains or regions , of Shb . ^^^ Overexpression of an SH 2 domain defective Shb causes diminished phosphorylation of SLP 76 and Vav and consequently decreased activation of c Jun kinase upon T cell receptor ( TCR ) stimulation . ^^^ |
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