| Interacting proteins: Q15464 and P62993 |
Pubmed |
SVM Score :0.99721367 |
| We have recently investigated the role of the adaptor protein Shb in the early events of T cell signaling and observed that Shb associates with Grb 2 , linker for activation of T cells ( LAT ) and the TCR zeta chain in Jurkat cells . 0.99721367^^^ |
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| Interacting proteins: Q15464 and P62993 |
Pubmed |
SVM Score :0.0 |
| Grb 2 binds proline rich motifs in Shb via its SH 3 domains . ^^^ As a result , a number of proteins detected in anti Shb and anti Grb 2 immunoprecipitates are shared , including phosphoproteins of 22 , 36 / 38 , 55 / 57 and 70 kDa . ^^^ |
|
| Interacting proteins: Q15464 and P62993 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of LAT creates binding sites for the Src homology 2 ( SH 2 ) domains of other proteins , including PLC gamma 1 , Grb 2 , Gads , Grap , 3BP2 , and Shb , and indirectly binds SOS , c Cbl , Vav , SLP 76 , and Itk . ^^^ |
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| Interacting proteins: Q15464 and P62993 |
Pubmed |
SVM Score :0.0 |
| NA |
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