| Interacting proteins: Q15464 and P35968 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that Shb is phosphorylated in an Src dependent manner upon vascular endothelial growth factor ( VEGF ) stimulation using porcine aortic endothelial cells expressing the human VEGF receptor 2 ( VEGFR 2 ) ( KDR ) . ^^^ |
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| Interacting proteins: Q15464 and P35968 |
Pubmed |
SVM Score :0.0 |
| Shb promotes blood vessel formation in embryoid bodies by augmenting vascular endothelial growth factor receptor 2 and platelet derived growth factor receptor beta signaling . ^^^ Embryoid bodies ( EBs ) differentiating from Shb overexpressing ES cells in vitro were stained for CD 31 or VEGFR 2 to visualize the formation of vascular structures . ^^^ Cells co expressing VEGFR 2 and PDGFR beta were commonly observed when Shb was overexpressed and inhibition of PDGF BB signaling reduced the amount of VEGFR 2 mRNA under these conditions . ^^^ Microarray analysis of VEGFR 2 / CD31 positive cells after 6 days of differentiation revealed numerous changes of expression of genes relating to an endothelial / hematopoietic phenotype in response to Shb overexpression . ^^^ The findings suggest that Shb may play a crucial role during early ES cell differentiation to vascular structures by transducing VEGFR 2 and PDGFR beta signals . . ^^^ |
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| Interacting proteins: Q15464 and P35968 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q15464 and P35968 |
Pubmed |
SVM Score :0.0 |
| NA |
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