| Interacting proteins: Q15464 and P11362 |
Pubmed |
SVM Score :0.0 |
| The Shb SH 2 domain also binds to in vitro phosphorylated fibroblast growth factor receptor 1 ( FGFR 1 ) mainly through position Y 776 . ^^^ |
|
| Interacting proteins: Q15464 and P11362 |
Pubmed |
SVM Score :0.0 |
| The Shb adaptor protein binds to tyrosine 766 in the FGFR 1 and regulates the Ras / MEK / MAPK pathway via FRS 2 phosphorylation in endothelial cells . ^^^ We report that the adaptor protein Shb is also able to bind tyrosine 766 in the FGFR 1 , via its SH 2 domain , resulting in its subsequent phosphorylation . ^^^ Overexpression of an SH 2 domain mutant Shb caused a dramatic reduction in FGFR 1 mediated FRS 2 phosphorylation with concomitant perturbment of the Ras / MEK / MAPK pathway . ^^^ Expression of the chimeric receptor mutant and the Shb SH 2 domain mutant resulted in a similar reduction in FGFR 1 mediated mitogenicity . ^^^ We conclude , that Shb binds to tyrosine 766 in the FGFR 1 and regulates FGF mediated mitogenicity via FRS 2 phosphorylation and the subsequent activation of the Ras / MEK / MAPK pathway . . ^^^ |
|
| Interacting proteins: Q15464 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|