| Scaffold attachment factors SAFB 1 and SAFB 2 : Innocent bystanders or critical players in breast tumorigenesis . ^^^ Scaffold attachment factor B 1 ( SAFB 1 ) and SAFB 2 are large , multifunctional proteins that have been implicated in numerous cellular processes including chromatin organization , transcriptional regulation , RNA splicing , and stress response . ^^^ For example , SAFB 2 can be found in both the nucleus and cytoplasm , whereas SAFB 1 seems to be mainly localized in the nucleus . ^^^ The possibility that SAFB 1 and SAFB 2 are novel breast tumor suppressor genes , and how they might function in this role , are discussed . . ^^^ Scaffold attachment factor B 1 ( SAFB 1 ) and SAFB 2 are large , multifunctional proteins that have been implicated in numerous cellular processes including chromatin organization , transcriptional regulation , RNA splicing , and stress response . ^^^ |