| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.7293932 |
| Characterization of elongin C functional domains required for interaction with elongin B and activation of elongin A . 0.7293932^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :1.0298135 |
| As a component of the VHL complex , Elongin C interacts directly with both Elongin B and the VHL protein . 1.0298135^^^ As a subunit of the Elongin complex , Elongin C interacts directly with the transcriptionally active Elongin A subunit and potently induces its elongation activity ; in addition , Elongin C interacts with the ubiquitin like Elongin B subunit , which regulates the interaction of Elongin C with Elongin A . 0.51601254^^^ |
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| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.72415782 |
| Identification of Elongin B sequences important for interaction with Elongin C . 0.72415782^^^ In this report , we show that the Elongin B ubiquitin like domain is necessary and sufficient for interaction with Elongin C and for positive regulation of Elongin A transcriptional activity . 0.68549526^^^ In addition , by site directed mutagenesis of the Elongin B ubiquitin like domain , we identify a short Elongin B region that is important for its interaction with Elongin C . 0.59686953^^^ |
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| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.58021644 |
| In contrast , elongin B residues required for binding to elongin C were not confined to a discrete colinear domain . 0.58021644^^^ |
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| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| Whereas Elongin C assembles with Elongin A to form an AC complex with increased specific activity , Elongin B , a member of the ubiquitin homology gene family , appears to serve a chaperone like function , facilitating assembly and enhancing stability of the Elongin ( SIII ) complex . . ^^^ |
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| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| To establish whether the VHL gene may have other functions , we here searched for additional cellular protein ( s ) that might bind to pVHL using a two hybrid system and identified seven independent clones , including elongin C , but not elongin B . ^^^ |
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| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| The VHL protein ( pVHL ) has been shown to form a stable complex with elongin B and elongin C , two factors that stabilize and activate the transcription elongation factor elongin A . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| This property of pVHL appears to be linked to its ability to bind to complexes containing elongin B , elongin C , and cullin 2 ( Cul 2 ) . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| Here , we report the molecular cloning of a Saccharomyces cerevisiae genomic DNA encoding Elongin C subunit and of Drosophila cDNAs encoding Elongin B and C subunits . ^^^ |
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| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| A frequently mutated region of pVHL can bind to complexes containing elongin B , elongin C and Cul 2 . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| In contrast pVHL 19 , in biochemical fractionation experiments , is equally distributed between the nucleus and cytosol and is not found in association with membranes . pVHL 19 , like pVHL 30 , can bind to elongin B , elongin C , and Hs Cul 2 in coimmunoprecipitation assays and can inhibit the production of hypoxia inducible proteins such as vascular endothelial growth factor ( VEGF ) and GLUT 1 when reintroduced into renal carcinoma cells that lack a wild type VHL allele . ^^^ |
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| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| Elongin B is a ubiquitin like protein , and Elongin C is a Skp 1 like protein that binds to a BC box motif that is present in both Elongin A and VHL and is distinct from the conserved F box motif recognized by Skp 1 . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| In vitro and in vivo studies indicate that the internal codon in the VHL mRNA is necessary and sufficient for production of pVHL 18 . pVHL 18 can bind to elongin B , elongin C , and Hs CUL 2 . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| The VHL protein is part of a complex that includes Elongin B , Elongin C , and Cullin 2 , proteins associated with transcriptional elongation and ubiquitination . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| The VHL gene product , pVHL , forms multiprotein complexes that contain elongin B , elongin C and Cul 2 , and negatively regulates hypoxia inducible mRNAs . pVHL is suspected to play a role in ubiquitination given the similarity of elongin C and Cul 2 with Skp 1 and Cdc 53 , respectively . pVHL can also interact with fibronectin and is required for the assembly of a fibronectin matrix . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| Mammalian elongin C interacts with both elongin A and elongin B , as well as with the von Hippel Lindau tumor suppressor protein VHL . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| The function of the pVHL protein has not been clarified . pVHL has been shown to form a complex with elongin B and elongin C ( VBC ) and with cullin ( CUL ) 2 . ^^^ Furthermore , naturally occurring pVHL missense mutations , including mutants capable of forming a complex with elongin B elongin C CUL 2 , fail to associate with p 100 and p 220 and can not exhibit the E 3 ligase activity . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that the folding and assembly of VHL into a complex with its partner proteins , elongin B and elongin C ( herein , elongin BC ) , is directly mediated by the chaperonin TRiC / CCT . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| Sequence homologues of elongin A and elongin C , but not elongin B , were identified in the yeast genome . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| The VHL gene product is reported to form complexes with various proteins including elongin B , elongin C , VBP 1 , fibronectin , Spl , CUL 2 , and HIF 1 . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| This region mediates the formation of a multiprotein VHL complex containing elongin B , elongin C , cul 2 , and Rbx 1 . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| No coding region sequence variations were detected for the elongin B , elongin C or Rbx 1 genes . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| The von Hippel Lindau tumor suppressor protein ( pVHL ) forms a protein complex ( VCB Cul 2 ) with elongin C , elongin B , Cul 2 , and Rbx 1 , which functions as a ubiquitin protein ligase ( E 3 ) . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| VHL protein ( pVHL ) is part of an E 3 ubiquitin ligase complex called VEC that is composed of elongin B , elongin C , cullin 2 , NEDD 8 , and Rbx 1 . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| The VHL gene product forms a heterotrimeric complex with elongin C , elongin B , and Cul 2 to target hypoxia inducible factors 1 and 2alpha for ubiquitin mediated degradation . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| Ubiquitination of APOBEC3G by an HIV 1 Vif Cullin 5 Elongin B Elongin C complex is essential for Vif function . ^^^ Vif targets APOBEC3G for ubiquitination and proteasomal degradation by forming an SCF like E 3 ubiquitin ligase complex composed of Cullin 5 , Elongin B , and Elongin C ( Vif BC Cul 5 ) through a novel SOCS box motif . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| The VHL ( von Hippel Lindau ) tumour suppressor protein forms a multi protein complex [ VCB ( pVHL elongin C elongin B ) Cul 2 ( Cullin 2 ) ] with elongin C , elongin B , Cul 2 and Rbx 1 , acting as a ubiquitin ligase ( E 3 ) and directing proteasome dependent degradation of targeted proteins . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| Crystal structure of the SOCS 2 elongin C elongin B complex defines a prototypical SOCS box ubiquitin ligase . ^^^ To elucidate the structural basis for SOCS 2 function , we determined the 1 . 9 A crystal structure of the ternary complex of SOCS 2 with elongin C and elongin B . ^^^ |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15370 and Q15369 |
Pubmed |
SVM Score :0.0 |
| NA |
|