| Interacting proteins: Q14241 and Q15370 |
Pubmed |
SVM Score :0.0 |
| Sequence homologues of elongin A and elongin C , but not elongin B , were identified in the yeast genome . ^^^ |
|
| Interacting proteins: Q14241 and Q15370 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14241 and Q15370 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14241 and Q15370 |
Pubmed |
SVM Score :0.0 |
| Elongin A is shown to function as the transcriptionally active component of Elongin ( SIII ) and Elongin B and C as regulatory subunits . ^^^ Whereas Elongin C assembles with Elongin A to form an AC complex with increased specific activity , Elongin B , a member of the ubiquitin homology gene family , appears to serve a chaperone like function , facilitating assembly and enhancing stability of the Elongin ( SIII ) complex . . ^^^ |
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| Interacting proteins: Q14241 and Q15370 |
Pubmed |
SVM Score :0.0 |
| Characterization of elongin C functional domains required for interaction with elongin B and activation of elongin A . ^^^ The Elongin ( SIII ) complex is composed of a transcriptionally active A subunit , a chaperone like B subunit , which promotes assembly and enhances stability of the Elongin ( SIII ) complex , and a regulatory C subunit , which ( 1 ) functions as a potent activator of Elongin A transcriptional activity , ( 2 ) interacts specifically with Elongin B to form an isolable Elongin BC complex , and ( 3 ) is bound and negatively regulated in vitro by the product of the von Hippel Lindau tumor suppressor gene . ^^^ In this report , we identify Elongin C mutants that fall into multiple functional classes based on their abilities to bind Elongin B and to bind and activate Elongin A under our assay conditions . ^^^ |
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| Interacting proteins: Q14241 and Q15370 |
Pubmed |
SVM Score :0.0 |
| The VHL protein ( pVHL ) has been shown to form a stable complex with elongin B and elongin C , two factors that stabilize and activate the transcription elongation factor elongin A . ^^^ |
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| Interacting proteins: Q14241 and Q15370 |
Pubmed |
SVM Score :0.0 |
| As a subunit of the Elongin complex , Elongin C interacts directly with the transcriptionally active Elongin A subunit and potently induces its elongation activity ; in addition , Elongin C interacts with the ubiquitin like Elongin B subunit , which regulates the interaction of Elongin C with Elongin A . ^^^ Here we show that interaction of Elongin C with the VHL tumor suppressor protein depends strongly on sequences in the C terminus of Elongin C but is independent of the N terminal Elongin C region required for binding to Elongin B and for binding and activation of Elongin A . ^^^ |
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| Interacting proteins: Q14241 and Q15370 |
Pubmed |
SVM Score :0.0 |
| Elongin B is a ubiquitin like protein , and Elongin C is a Skp 1 like protein that binds to a BC box motif that is present in both Elongin A and VHL and is distinct from the conserved F box motif recognized by Skp 1 . ^^^ |
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| Interacting proteins: Q14241 and Q15370 |
Pubmed |
SVM Score :0.0 |
| The von Hippel Lindau ( VHL ) tumour suppressorgene product is believed to be involved in the down regulation of transcriptional elongation by preventing the association of elongin B and C with the catalytic subunit elongin A . ^^^ |
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| Interacting proteins: Q14241 and Q15370 |
Pubmed |
SVM Score :0.0 |
| Elongin B is found in cells as a subunit of the heterodimeric Elongin BC complex , which was originally identified as a positive regulator of RNA polymerase 2 elongation factor Elongin A and subsequently as a component of the multiprotein von Hippel Lindau tumor suppressor and suppressor of cytokine signaling complexes . ^^^ As part of our effort to understand how the Elongin BC complex regulates the activity of Elongin A , we are characterizing Elongin B functional domains . ^^^ In this report , we show that the Elongin B ubiquitin like domain is necessary and sufficient for interaction with Elongin C and for positive regulation of Elongin A transcriptional activity . ^^^ |
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| Interacting proteins: Q14241 and Q15370 |
Pubmed |
SVM Score :0.0 |
| Mammalian elongin C interacts with both elongin A and elongin B , as well as with the von Hippel Lindau tumor suppressor protein VHL . ^^^ |
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| Interacting proteins: Q14241 and Q15370 |
Pubmed |
SVM Score :0.0 |
| Elongin A , the largest subunit of the elongin complex , is the transcriptionally active subunit , while the smaller elongin B and C subunits appear to act as regulatory subunits . ^^^ |
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