| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| Here , Hs CUL 2 , a member of the recently identified multigene family , the cullins , is shown to specifically associate with the trimeric pVHL elongin B C ( VBC ) complex in vitro and in vivo . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| This property of pVHL appears to be linked to its ability to bind to complexes containing elongin B , elongin C , and cullin 2 ( Cul 2 ) . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| A frequently mutated region of pVHL can bind to complexes containing elongin B , elongin C and Cul 2 . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| The VHL protein is part of a complex that includes Elongin B , Elongin C , and Cullin 2 , proteins associated with transcriptional elongation and ubiquitination . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| The VHL gene product , pVHL , forms multiprotein complexes that contain elongin B , elongin C and Cul 2 , and negatively regulates hypoxia inducible mRNAs . pVHL is suspected to play a role in ubiquitination given the similarity of elongin C and Cul 2 with Skp 1 and Cdc 53 , respectively . pVHL can also interact with fibronectin and is required for the assembly of a fibronectin matrix . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| Furthermore , naturally occurring pVHL missense mutations , including mutants capable of forming a complex with elongin B elongin C CUL 2 , fail to associate with p 100 and p 220 and can not exhibit the E 3 ligase activity . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| This activity has been linked to its ability to form multimeric complexes that contain elongin C , elongin B , and Cul 2 . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| The VHL gene product is reported to form complexes with various proteins including elongin B , elongin C , VBP 1 , fibronectin , Spl , CUL 2 , and HIF 1 . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| This region mediates the formation of a multiprotein VHL complex containing elongin B , elongin C , cul 2 , and Rbx 1 . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| The von Hippel Lindau tumour suppressor gene product ( pVHL ) associates with the elongin B and C and Cul 2 proteins to form a ubiquitin ligase complex ( VCBC ) . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| The VHL gene product ( pVHL ) forms a multimeric complex with the elongin B and C , Cul 2 and Rbx 1 proteins ( VCBCR complex ) , which is homologous to the SCF family of ubiquitin ligase complexes . ^^^ Although ( a ) activation of HIF could occur through mutation of another region of HIF a , and ( b ) epigenetic silencing of elongin B / C , Cul 2 or Rbx 1 can not be excluded , these findings suggest that pVHL may represent the sole mutational target through which the VCBR complex is disrupted in CC RCC . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| The von Hippel Lindau tumor suppressor protein ( pVHL ) forms a protein complex ( VCB Cul 2 ) with elongin C , elongin B , Cul 2 , and Rbx 1 , which functions as a ubiquitin protein ligase ( E 3 ) . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| VHL protein ( pVHL ) is part of an E 3 ubiquitin ligase complex called VEC that is composed of elongin B , elongin C , cullin 2 , NEDD 8 , and Rbx 1 . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| The VHL gene product forms a heterotrimeric complex with elongin C , elongin B , and Cul 2 to target hypoxia inducible factors 1 and 2alpha for ubiquitin mediated degradation . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| The VHL ( von Hippel Lindau ) tumour suppressor protein forms a multi protein complex [ VCB ( pVHL elongin C elongin B ) Cul 2 ( Cullin 2 ) ] with elongin C , elongin B , Cul 2 and Rbx 1 , acting as a ubiquitin ligase ( E 3 ) and directing proteasome dependent degradation of targeted proteins . ^^^ |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15370 and Q13617 |
Pubmed |
SVM Score :0.0 |
| NA |
|