| Interacting proteins: Q15370 and P62877 |
Pubmed |
SVM Score :0.0 |
| This region mediates the formation of a multiprotein VHL complex containing elongin B , elongin C , cul 2 , and Rbx 1 . ^^^ |
|
| Interacting proteins: Q15370 and P62877 |
Pubmed |
SVM Score :0.0 |
| The pVHL associated SCF ubiquitin ligase complex : molecular genetic analysis of elongin B and C , Rbx 1 and HIF 1alpha in renal cell carcinoma . ^^^ The VHL gene product ( pVHL ) forms a multimeric complex with the elongin B and C , Cul 2 and Rbx 1 proteins ( VCBCR complex ) , which is homologous to the SCF family of ubiquitin ligase complexes . ^^^ No coding region sequence variations were detected for the elongin B , elongin C or Rbx 1 genes . ^^^ Although ( a ) activation of HIF could occur through mutation of another region of HIF a , and ( b ) epigenetic silencing of elongin B / C , Cul 2 or Rbx 1 can not be excluded , these findings suggest that pVHL may represent the sole mutational target through which the VCBR complex is disrupted in CC RCC . ^^^ |
|
| Interacting proteins: Q15370 and P62877 |
Pubmed |
SVM Score :0.0 |
| The von Hippel Lindau tumor suppressor protein ( pVHL ) forms a protein complex ( VCB Cul 2 ) with elongin C , elongin B , Cul 2 , and Rbx 1 , which functions as a ubiquitin protein ligase ( E 3 ) . ^^^ |
|
| Interacting proteins: Q15370 and P62877 |
Pubmed |
SVM Score :0.0 |
| VHL protein ( pVHL ) is part of an E 3 ubiquitin ligase complex called VEC that is composed of elongin B , elongin C , cullin 2 , NEDD 8 , and Rbx 1 . ^^^ |
|
| Interacting proteins: Q15370 and P62877 |
Pubmed |
SVM Score :0.0 |
| The VHL ( von Hippel Lindau ) tumour suppressor protein forms a multi protein complex [ VCB ( pVHL elongin C elongin B ) Cul 2 ( Cullin 2 ) ] with elongin C , elongin B , Cul 2 and Rbx 1 , acting as a ubiquitin ligase ( E 3 ) and directing proteasome dependent degradation of targeted proteins . ^^^ |
|
| Interacting proteins: Q15370 and P62877 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15370 and P62877 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15370 and P62877 |
Pubmed |
SVM Score :0.0 |
| NA |
|