| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.60789591 |
| Germline mutations in VHL patients , as well as somatic mutations in different tumors , including hemangioblastomas , have been identified , its ability to act as a tumor suppressor in vivo has been confirmed , and interaction with transcription factors Elongin B and C leading to inhibition of transcriptional elongation has been demonstrated . 0.60789591^^^ |
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| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :1.1653877 |
| The VHL protein ( pVHL ) has been shown to form a stable complex with elongin B and elongin C , two factors that stabilize and activate the transcription elongation factor elongin A . 1.1653877^^^ |
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| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.94706063 |
| The function of the pVHL protein has not been clarified . pVHL has been shown to form a complex with elongin B and elongin C ( VBC ) and with cullin ( CUL ) 2 . 0.94706063^^^ |
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| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.7693257 |
| The von Hippel Lindau tumour suppressor gene product ( pVHL ) associates with the elongin B and C and Cul 2 proteins to form a ubiquitin ligase complex ( VCBC ) . 0.7693257^^^ |
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| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.53764591 |
| The VHL gene product ( pVHL ) forms a multimeric complex with the elongin B and C , Cul 2 and Rbx 1 proteins ( VCBCR complex ) , which is homologous to the SCF family of ubiquitin ligase complexes . 0.53764591^^^ |
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| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| The VHL protein was shown to bind tightly and specifically to the Elongin B and C subunits and to inhibit Elongin ( SIII ) transcriptional activity in vitro . ^^^ |
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| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| To establish whether the VHL gene may have other functions , we here searched for additional cellular protein ( s ) that might bind to pVHL using a two hybrid system and identified seven independent clones , including elongin C , but not elongin B . ^^^ |
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| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| As a component of the VHL complex , Elongin C interacts directly with both Elongin B and the VHL protein . ^^^ Here we show that interaction of Elongin C with the VHL tumor suppressor protein depends strongly on sequences in the C terminus of Elongin C but is independent of the N terminal Elongin C region required for binding to Elongin B and for binding and activation of Elongin A . ^^^ |
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| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| This property of pVHL appears to be linked to its ability to bind to complexes containing elongin B , elongin C , and cullin 2 ( Cul 2 ) . ^^^ |
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| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| A frequently mutated region of pVHL can bind to complexes containing elongin B , elongin C and Cul 2 . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| In contrast pVHL 19 , in biochemical fractionation experiments , is equally distributed between the nucleus and cytosol and is not found in association with membranes . pVHL 19 , like pVHL 30 , can bind to elongin B , elongin C , and Hs Cul 2 in coimmunoprecipitation assays and can inhibit the production of hypoxia inducible proteins such as vascular endothelial growth factor ( VEGF ) and GLUT 1 when reintroduced into renal carcinoma cells that lack a wild type VHL allele . ^^^ |
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| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| Elongin B is a ubiquitin like protein , and Elongin C is a Skp 1 like protein that binds to a BC box motif that is present in both Elongin A and VHL and is distinct from the conserved F box motif recognized by Skp 1 . ^^^ |
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| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| The von Hippel Lindau ( VHL ) tumour suppressorgene product is believed to be involved in the down regulation of transcriptional elongation by preventing the association of elongin B and C with the catalytic subunit elongin A . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| In vitro and in vivo studies indicate that the internal codon in the VHL mRNA is necessary and sufficient for production of pVHL 18 . pVHL 18 can bind to elongin B , elongin C , and Hs CUL 2 . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| The VHL protein is part of a complex that includes Elongin B , Elongin C , and Cullin 2 , proteins associated with transcriptional elongation and ubiquitination . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| The VHL gene product , pVHL , forms multiprotein complexes that contain elongin B , elongin C and Cul 2 , and negatively regulates hypoxia inducible mRNAs . pVHL is suspected to play a role in ubiquitination given the similarity of elongin C and Cul 2 with Skp 1 and Cdc 53 , respectively . pVHL can also interact with fibronectin and is required for the assembly of a fibronectin matrix . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| Mammalian elongin C interacts with both elongin A and elongin B , as well as with the von Hippel Lindau tumor suppressor protein VHL . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| To understand this process in greater detail , we performed a series of in vitro binding assays using pVHL , elongin B , and elongin C variants as well as synthetic peptide competitors derived from pVHL or elongin C . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that the folding and assembly of VHL into a complex with its partner proteins , elongin B and elongin C ( herein , elongin BC ) , is directly mediated by the chaperonin TRiC / CCT . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| The von Hippel Lindau ( VHL ) tumor suppressor protein down regulates transcription by transcriptional elongation enhanced by antagonizing elongin B and C . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| The VHL gene product is reported to form complexes with various proteins including elongin B , elongin C , VBP 1 , fibronectin , Spl , CUL 2 , and HIF 1 . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| This region mediates the formation of a multiprotein VHL complex containing elongin B , elongin C , cul 2 , and Rbx 1 . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| It has been demonstrated that von Hippel Lindau disease ( VHL ) tumor suppressor gene product possesses the SOCS box that forms a complex with Elongin B and C and Cullin 2 , and it functions as a ubiquitin ligase . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| The von Hippel Lindau tumor suppressor protein ( pVHL ) forms a protein complex ( VCB Cul 2 ) with elongin C , elongin B , Cul 2 , and Rbx 1 , which functions as a ubiquitin protein ligase ( E 3 ) . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| In contrast , the VHL protein is stabilized by interaction with the Elongin B and C subunits of CBC ( VHL ) in cells . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| VHL protein ( pVHL ) is part of an E 3 ubiquitin ligase complex called VEC that is composed of elongin B , elongin C , cullin 2 , NEDD 8 , and Rbx 1 . ^^^ VHL protein ( pVHL ) is part of an E 3 ubiquitin ligase complex called VEC that is composed of elongin B , elongin C , cullin 2 , NEDD 8 , and Rbx 1 . ^^^ |
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| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| The VHL gene product forms a heterotrimeric complex with elongin C , elongin B , and Cul 2 to target hypoxia inducible factors 1 and 2alpha for ubiquitin mediated degradation . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| The VHL ( von Hippel Lindau ) tumour suppressor protein forms a multi protein complex [ VCB ( pVHL elongin C elongin B ) Cul 2 ( Cullin 2 ) ] with elongin C , elongin B , Cul 2 and Rbx 1 , acting as a ubiquitin ligase ( E 3 ) and directing proteasome dependent degradation of targeted proteins . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| Inactivation of the VHL tumor suppressor protein with loss of function of the VHL protein , and Elongin B , C complex results in a dysfunction of the ubquitination of hypoxia inducible factor , which is an important step in the development of highly vascular tumors . ^^^ |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15370 and P40337 |
Pubmed |
SVM Score :0.0 |
| NA |
|