| Interacting proteins: P61326 and Q15287 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61326 and Q15287 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61326 and Q15287 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P61326 and Q15287 |
Pubmed |
SVM Score :0.0 |
| Mass spectrometry and Western blotting of purified H , C , and mRNP complexes revealed that at least one EJC component , REF / Aly , can interact with pre mRNA prior to spliceosome assembly , whereas Y 14 , Magoh , RNPS 1 , UAP 56 , and SRm 160 are found in intermediate containing spliceosomes . ^^^ |
|
| Interacting proteins: P61326 and Q15287 |
Pubmed |
SVM Score :0.0 |
| The proteins of the EJC , Y 14 , Magoh , Aly / REF , RNPS 1 , Srm 160 , and Upf 3 , play critical roles in postsplicing processing , including nuclear export and cytoplasmic localization of the mRNA , and the nonsense mediated mRNA decay ( NMD ) surveillance process . ^^^ |
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| Interacting proteins: P61326 and Q15287 |
Pubmed |
SVM Score :0.0 |
| Translational stimulation can be replicated by tethering the EJC proteins Y 14 , Magoh , and RNPS 1 or the nonsense mediated decay ( NMD ) factors Upf 1 , Upf 2 , and Upf3b to an intronless reporter mRNA . ^^^ |
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| Interacting proteins: P61326 and Q15287 |
Pubmed |
SVM Score :0.0 |
| Using in situ hybridization and confocal microscopy , we observe accumulation of EJC proteins ( REF / Aly , Y 14 , SRm 160 , UAP 56 , RNPS 1 , and Magoh ) and core spliceosome components ( U snRNPs ) at sites of transcription . ^^^ |
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| Interacting proteins: P61326 and Q15287 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , recent evidence strongly suggests that the NMD factors UPF 1 , UPF 2 , UPF3B , RNPS 1 , Y 14 and MAGOH also promote translation of normal mRNAs in mammalian cells . ^^^ |
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| Interacting proteins: P61326 and Q15287 |
Pubmed |
SVM Score :0.0 |
| Specifically , Y 14 , MAGOH , and eIF4A3 can activate NMD in an UPF 2 independent manner , whereas RNPS 1 induced NMD requires UPF 2 . ^^^ We identify the relevant regions of RNPS 1 , eIF4A3 , Y 14 , and MAGOH , which are essential for NMD and provide insights into the formation of complexes , that classify alternative NMD pathways . ^^^ |
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