| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.66033651 |
| We have described a nectin trans hetero interaction network : nectin 3 binds to nectin 1 , nectin 2 , and PVR ; nectin 1 also binds to nectin 4 . 0.66033651^^^ Nectin 3 and nectin 4 share a common binding region in the nectin 1 5 domain : ( 1 ) nectin 3 strongly competed with nectin 4 binding , ( 2 ) nectin 3 and nectin 4 binding to nectin 1 was reduced by a number of monoclonal antibodies directed against the nectin 1 5 domain , and ( 3 ) the glycoprotein D of herpes simplex virus 1 that binds to the 5 domain of nectin 1 reduced nectin 3 and nectin 4 binding . 0.5369923^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.50198884 |
| Our results indicate that E cadherin is the key molecule involved in cell adhesion and that the regulation of E cadherin based adhesion involving cellular nectin 1 trans interacting with nectin 3 is qualitatively different from that involving cellular nectin 3 trans interacting with nectin 1 and depends on the nectin levels expressed by cells . . 0.50198884^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| Mutations in region 1 previously shown to severely impair herpes simplex virus ( HSV ) entry activity , but not pseudorabies virus ( PRV ) or bovine herpesvirus 1 ( BHV 1 ) entry , did not reduce homotypic trans interactions for either nectin 1 or nectin 2 or binding of nectin 3 to nectin 1 . ^^^ Binding of nectin 1 to nectin 3 was not affected . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| First , a soluble chimeric recombinant nectin 4 ectodomain ( nectin 4 Fc ) trans interacts with cells expressing nectin 1 but not with cells expressing nectin 2 , nectin 3 , or PVR / CD155 . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| Each nectin forms a homo cis dimer followed by formation of a homo trans dimer , but nectin 3 furthermore forms a hetero trans dimer with nectin 1 or 2 , and the formation of each hetero trans dimer is stronger than that of each homo trans dimer . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| HSC 39 cells expressed nectin 1 , 2 , and afadin , but not nectin 3 . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| We prepared here pure recombinant proteins of extracellular fragments of nectin 3 containing various combinations of Ig like loops , all of which were fused to the Fc portion of IgG and formed homo cis dimers through the Fc portion , and of an extracellular fragment of nectin 1 containing three Ig like loops which was fused to secreted alkaline phosphatase and formed homo cis dimers . ^^^ We showed here by use of these proteins that the first Ig like loop of nectin 3 was essential and sufficient for the formation of trans dimers with nectin 1 , but that the second Ig like loop of nectin 3 was furthermore necessary for its cell cell adhesion activity . . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| Roles of cell adhesion molecules nectin 1 and nectin 3 in ciliary body development . ^^^ To further explore the function of nectins , we generated nectin 1 / and nectin 3 / ) mice . ^^^ Both nectin 1 / and nectin 3 / mice showed a virtually identical ocular phenotype , microphthalmia , accompanied by a separation of the apex apex contact between the pigment and non pigment cell layers of the ciliary epithelia . ^^^ Immunofluorescence and immunoelectron microscopy revealed that nectin 1 and nectin 3 , but not nectin 2 , localized at the apex apex junctions between the pigment and non pigment cell layers of the ciliary epithelia . ^^^ However , nectin 1 / and nectin 3 / mice showed no impairment of the apicolateral junctions between the pigment epithelia where nectin 1 , nectin 2 and nectin 3 localized , or of the apicolateral junctions between the non pigment epithelia where nectin 2 and nectin 3 , but not nectin 1 , localized . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| At the mossy fiber terminals of hippocampus , nectin 1 and nectin 3 localize at the presynaptic and postsynaptic sides of synaptic junctions , respectively , and their trans interactions play a role in formation of synapses in cooperation with N cadherin . ^^^ It furthermore showed Ca2+ independent heterophilic cell cell adhesion activity with Necl 2 / IGSF4 / RA175 / SgIGSF / TSLC1 / SynCAM1 from now on referred to as Necl 2 , nectin 1 and nectin 3 , but not with Necl 5 or nectin 2 . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Immunoblot analysis revealed expression of nectin 2 and nectin 3 but not nectin 1 in ovarian granulosa cells . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| Cell cell adhesion molecules nectin 1 and nectin 3 asymmetrically localize at the pre and post synaptic sides of PAJs , respectively . ^^^ To reveal the definitive role of nectins , we analyzed nectin 1 / and nectin 3 ( / ) mice . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| To clearly explore the effect of trans interacting nectin on the small G proteins , we use L fibroblasts stably expressing nectin 1 ( nectin 1 L cells ) and the extracellular domain of nectin 3 fused to human IgG Fc ( Nef 3 ) . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| Nonetheless , it was not yet certain whether or not other PRR family members ( PRR 9 , PRR 7 , PRR 5 and PRR 3 ) are implicated in clock function per se . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| We found that PRR 2 contains a different class of IL 6 responsive element ( RE ) from that reported for the human Hx gene , and that PRR 1 and PRR 3 participate in the basal expression of rat Hx in HepG 2 cells . . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| The second and third repeats in ActA are especially important , and the minimal sequence of ActA capable of interacting with LaXp 180 was a proline and glutamate rich stretch of PRR 3 fused to part of the N terminal sequence of ActA . ^^^ Further analysis using site specific mutations located in either the C terminal region of LaXp 180 or the proline rich motif of PRR 3 of ActA showed that three positively charged amino acids in LaXp 180 and two negatively charged amino acids in ActA are critical for the interaction of the two proteins . . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| TOC 1 is a member of a small family of proteins , designated as ARABIDOPSIS PSEUDO RESPONSE REGULATOR , including PRR1 / TOC1 , PRR 3 , PRR 5 , PRR 7 and PRR 9 . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| In this connection , we have been characterizing a small family of proteins , designated ARABIDOPSIS PSEUDO RESPONSE REGULATOR ( PRR 1 , PRR 3 , PRR 5 , PRR 7 , and PRR 9 ) , based on the fact that one of the members ( PRR 1 ) is identical to TOC 1 . ^^^ |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15223 and Q9NQS3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.66033651 |
| We have described a nectin trans hetero interaction network : nectin 3 binds to nectin 1 , nectin 2 , and PVR ; nectin 1 also binds to nectin 4 . 0.66033651^^^ Nectin 3 and nectin 4 share a common binding region in the nectin 1 5 domain : ( 1 ) nectin 3 strongly competed with nectin 4 binding , ( 2 ) nectin 3 and nectin 4 binding to nectin 1 was reduced by a number of monoclonal antibodies directed against the nectin 1 5 domain , and ( 3 ) the glycoprotein D of herpes simplex virus 1 that binds to the 5 domain of nectin 1 reduced nectin 3 and nectin 4 binding . 0.5369923^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.50198884 |
| Our results indicate that E cadherin is the key molecule involved in cell adhesion and that the regulation of E cadherin based adhesion involving cellular nectin 1 trans interacting with nectin 3 is qualitatively different from that involving cellular nectin 3 trans interacting with nectin 1 and depends on the nectin levels expressed by cells . . 0.50198884^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| First , a soluble chimeric recombinant nectin 4 ectodomain ( nectin 4 Fc ) trans interacts with cells expressing nectin 1 but not with cells expressing nectin 2 , nectin 3 , or PVR / CD155 . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| Each nectin forms a homo cis dimer followed by formation of a homo trans dimer , but nectin 3 furthermore forms a hetero trans dimer with nectin 1 or 2 , and the formation of each hetero trans dimer is stronger than that of each homo trans dimer . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| HSC 39 cells expressed nectin 1 , 2 , and afadin , but not nectin 3 . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| Mutations in region 1 previously shown to severely impair herpes simplex virus ( HSV ) entry activity , but not pseudorabies virus ( PRV ) or bovine herpesvirus 1 ( BHV 1 ) entry , did not reduce homotypic trans interactions for either nectin 1 or nectin 2 or binding of nectin 3 to nectin 1 . ^^^ Binding of nectin 1 to nectin 3 was not affected . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| We prepared here pure recombinant proteins of extracellular fragments of nectin 3 containing various combinations of Ig like loops , all of which were fused to the Fc portion of IgG and formed homo cis dimers through the Fc portion , and of an extracellular fragment of nectin 1 containing three Ig like loops which was fused to secreted alkaline phosphatase and formed homo cis dimers . ^^^ We showed here by use of these proteins that the first Ig like loop of nectin 3 was essential and sufficient for the formation of trans dimers with nectin 1 , but that the second Ig like loop of nectin 3 was furthermore necessary for its cell cell adhesion activity . . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| Roles of cell adhesion molecules nectin 1 and nectin 3 in ciliary body development . ^^^ To further explore the function of nectins , we generated nectin 1 / and nectin 3 / ) mice . ^^^ Both nectin 1 / and nectin 3 / mice showed a virtually identical ocular phenotype , microphthalmia , accompanied by a separation of the apex apex contact between the pigment and non pigment cell layers of the ciliary epithelia . ^^^ Immunofluorescence and immunoelectron microscopy revealed that nectin 1 and nectin 3 , but not nectin 2 , localized at the apex apex junctions between the pigment and non pigment cell layers of the ciliary epithelia . ^^^ However , nectin 1 / and nectin 3 / mice showed no impairment of the apicolateral junctions between the pigment epithelia where nectin 1 , nectin 2 and nectin 3 localized , or of the apicolateral junctions between the non pigment epithelia where nectin 2 and nectin 3 , but not nectin 1 , localized . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| At the mossy fiber terminals of hippocampus , nectin 1 and nectin 3 localize at the presynaptic and postsynaptic sides of synaptic junctions , respectively , and their trans interactions play a role in formation of synapses in cooperation with N cadherin . ^^^ It furthermore showed Ca2+ independent heterophilic cell cell adhesion activity with Necl 2 / IGSF4 / RA175 / SgIGSF / TSLC1 / SynCAM1 from now on referred to as Necl 2 , nectin 1 and nectin 3 , but not with Necl 5 or nectin 2 . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Immunoblot analysis revealed expression of nectin 2 and nectin 3 but not nectin 1 in ovarian granulosa cells . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| Cell cell adhesion molecules nectin 1 and nectin 3 asymmetrically localize at the pre and post synaptic sides of PAJs , respectively . ^^^ To reveal the definitive role of nectins , we analyzed nectin 1 / and nectin 3 ( / ) mice . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| To clearly explore the effect of trans interacting nectin on the small G proteins , we use L fibroblasts stably expressing nectin 1 ( nectin 1 L cells ) and the extracellular domain of nectin 3 fused to human IgG Fc ( Nef 3 ) . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| We found that PRR 2 contains a different class of IL 6 responsive element ( RE ) from that reported for the human Hx gene , and that PRR 1 and PRR 3 participate in the basal expression of rat Hx in HepG 2 cells . . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| The second and third repeats in ActA are especially important , and the minimal sequence of ActA capable of interacting with LaXp 180 was a proline and glutamate rich stretch of PRR 3 fused to part of the N terminal sequence of ActA . ^^^ Further analysis using site specific mutations located in either the C terminal region of LaXp 180 or the proline rich motif of PRR 3 of ActA showed that three positively charged amino acids in LaXp 180 and two negatively charged amino acids in ActA are critical for the interaction of the two proteins . . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| TOC 1 is a member of a small family of proteins , designated as ARABIDOPSIS PSEUDO RESPONSE REGULATOR , including PRR1 / TOC1 , PRR 3 , PRR 5 , PRR 7 and PRR 9 . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| In this connection , we have been characterizing a small family of proteins , designated ARABIDOPSIS PSEUDO RESPONSE REGULATOR ( PRR 1 , PRR 3 , PRR 5 , PRR 7 , and PRR 9 ) , based on the fact that one of the members ( PRR 1 ) is identical to TOC 1 . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| Nonetheless , it was not yet certain whether or not other PRR family members ( PRR 9 , PRR 7 , PRR 5 and PRR 3 ) are implicated in clock function per se . ^^^ |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQS3 and Q15223 |
Pubmed |
SVM Score :0.0 |
| NA |
|