| Interacting proteins: Q9UMD9 and Q15149 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UMD9 and Q15149 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UMD9 and Q15149 |
Pubmed |
SVM Score :0.0 |
| The fraction also contains the hemidesmosomal components HD 1 , BP 230 and BP 180 . ^^^ |
|
| Interacting proteins: Q9UMD9 and Q15149 |
Pubmed |
SVM Score :0.0 |
| All 3 major hemidesmosomal components BP 180 , BP 230 , and HD 1 antigen are likewise present . ^^^ |
|
| Interacting proteins: Q9UMD9 and Q15149 |
Pubmed |
SVM Score :0.0 |
| The normal basal cells exhibited a polarized distribution of hemidesmosomal associated proteins including BP 180 , BP 230 , HD 1 , plectin , laminin gamma 2 ( B2t ) , collagen 7 , and the corresponding integrin laminin receptors alpha 6 beta 1 and alpha 6 beta 4 . ^^^ In contrast , the carcinoma cells uniformly lacked hemidesmosomal structures , the integrin alpha 6 beta 4 , BP 180 , laminin gamma 2 ( B2t ) , and collagen 7 but did express BP 230 ( 30 % ) , plectin , HD 1 ( 15 % ) , and the integrin laminin receptors alpha 3 beta 1 and alpha 6 beta 1 . ^^^ |
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| Interacting proteins: Q9UMD9 and Q15149 |
Pubmed |
SVM Score :0.0 |
| In addition , type 7 collagen and the BP 180 protein which are associated with hemidesmosomes are lost , although the BP 230 , plectin , and HD 1 proteins are variably expressed . ^^^ |
|
| Interacting proteins: Q9UMD9 and Q15149 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence analysis showed that the beta 4 subunit was absent in the skin of the PA JEB patient , whereas the alpha 6 subunit appeared to be normally distributed along the basement membrane zone , as were the other hemidesmosomal components BP 230 , BP 180 and HD 1 . ^^^ The few hemidesmosome like structures found in cultured keratinocytes from the PA JEB patient contained the hemidesmosomal components BP 230 , BP 180 and HD 1 , but not the integrin alpha 6 subunit . ^^^ |
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| Interacting proteins: Q9UMD9 and Q15149 |
Pubmed |
SVM Score :0.0 |
| We report here that these cells possess HD 1 but not BP 230 or BP 180 ; two other hemidesmosomal constituents , and express only traces of the alpha 6 beta 4 integrin . ^^^ |
|
| Interacting proteins: Q9UMD9 and Q15149 |
Pubmed |
SVM Score :0.0 |
| In COS 7 cells , which do not express alpha 6 beta 4 or the hemidesmosomal components BP 230 and BP 180 , HD 1 is associated with the cytoskeleton , but after transfecting the cells with cDNAs for human alpha 6 and beta 4 , it was , instead , colocalized with alpha 6 beta 4 at the basal side of the cells . ^^^ |
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| Interacting proteins: Q9UMD9 and Q15149 |
Pubmed |
SVM Score :0.0 |
| Bullous pemphigoid antigen 2 ( BP 180 ) , bullous pemphigoid antigen 1 ( BP 230 ) , plectin / hemidesmosomal 1 protein ( HD 1 ) , laminin 5 , laminin alpha 5 , laminin beta 1 , type 7 collagen , tenascin C , beta 4 , alphavbeta 5 , alpha 5 and alpha 9 integrins were studied in intact blisters and open wounds by immunohistochemistry . ^^^ |
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| Interacting proteins: Q9UMD9 and Q15149 |
Pubmed |
SVM Score :0.0 |
| Of the first importance are the HD 1 inner plaque protein , supposed to be associated with intermediate filaments , and the transmembrane components in the dense plaque ( BPAG 2 and alpha 6 beta 4 integrin ) , whose extracellular domains directly interact with basement membrane components . ^^^ |
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| Interacting proteins: Q9UMD9 and Q15149 |
Pubmed |
SVM Score :0.0 |
| These include mutations in the type 7 collagen gene ( COL7A1 ) in the dystrophic ( severely scarring ) forms of EB ; mutations in the laminin 5 genes ( LAMA 3 , LAMB 3 and LAMC 2 ) in a lethal ( Herlitz ) variant of junctional EB ; aberrations in the type 17 collagen gene ( COL17A1 ) in non lethal forms of junctional EB ; mutations in the alpha 6 and beta 4 integrin genes in a distinct hemidesmosomal variant of EB with congenital pyloric atresia ; and mutations in the plectin gene ( PLEC 1 ) in a form of EB associated with late onset muscular dystrophy . ^^^ |
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