| Interacting proteins: P16144 and Q15149 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescence analysis showed that the beta 4 subunit was absent in the skin of the PA JEB patient , whereas the alpha 6 subunit appeared to be normally distributed along the basement membrane zone , as were the other hemidesmosomal components BP 230 , BP 180 and HD 1 . ^^^ The few hemidesmosome like structures found in cultured keratinocytes from the PA JEB patient contained the hemidesmosomal components BP 230 , BP 180 and HD 1 , but not the integrin alpha 6 subunit . ^^^ |
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| Interacting proteins: P16144 and Q15149 |
Pubmed |
SVM Score :0.0 |
| The subcellular distribution of the high molecular mass protein , HD 1 , is determined by the cytoplasmic domain of the integrin beta 4 subunit . ^^^ We have studied the distribution and expression of HD 1 in the GD 25 cells , derived from murine embryonal stem cells deficient for the beta 1 integrin subunit . ^^^ We report here that these cells possess HD 1 but not BP 230 or BP 180 ; two other hemidesmosomal constituents , and express only traces of the alpha 6 beta 4 integrin . ^^^ In OVCAR 4 cells , derived from a human ovarian carcinoma which , like GD 25 cells , only weakly express alpha 6 beta 4 , HD 1 was also localized in focal contacts . ^^^ Upon transfection of both GD 25 and OVCAR 4 cells with cDNA for the human beta 4 subunit the subcellular distribution of HD 1 changed significantly . ^^^ |
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| Interacting proteins: P16144 and Q15149 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16144 and Q15149 |
Pubmed |
SVM Score :0.0 |
| NA |
|