Although EEA 1 CT and EEA 1 NT interacted strongly with wild type Rab5b in the two hybrid system , we detected no interaction with wild type Rab5a , even though GTPase deficient mutants of both Rab5a and Rab5b interacted equally well with EEA 1 . 0.73862654^^^ Direct interaction of EEA 1 with Rab5b . 0.50321184^^^