| Interacting proteins: Q9HBI1 and Q15052 |
Pubmed |
SVM Score :0.0 |
| In an attempt to get insight into the biological function of ARHGEF 6 and the upstream signaling cascades leading to its activation , we used the full length coding region of ARHGEF 6 as bait in yeast two hybrid screens and identified PARVB ( beta parvin or affixin ) as a novel binding partner . ^^^ |
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| Interacting proteins: Q9HBI1 and Q15052 |
Pubmed |
SVM Score :0.0 |
| The first CH domain of affixin activates Cdc 42 and Rac 1 through alphaPIX , a Cdc42 / Rac1 specific guanine nucleotide exchanging factor . ^^^ Affixin full length and RP 1 co immunoprecipitated with alphaPIX , a Cdc42 / Rac1 specific guanine nucleotide exchanging factor ( GEF ) , and they co localized at the tips of lamellipodia in motile cells . ^^^ |
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| Interacting proteins: Q9HBI1 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Taken together with the results that gamma parvin could form a complex with some important cytoskeletal proteins , such as alphaPIX , alpha actinin , and paxillin as demonstrated for affixin and actopaxin ( alpha parvin ) , the results in this study suggest that the ILK gamma parvin complex is critically involved in the initial integrin signaling for leukocyte migration . . ^^^ |
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| Interacting proteins: Q9HBI1 and Q15052 |
Pubmed |
SVM Score :0.0 |
| While PARVA inhibits the activities of Rac 1 and testicular kinase 1 and cell spreading , PARVB binds alphaPIX and alpha actinin , and can promote cell spreading . ^^^ |
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