| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| In addition , interaction of ARHGEF 6 to ARHGEF 7 ( betaPIX or Cool 1 ) , a close homolog of ARHGEF 6 , was confirmed . ^^^ Binding between ARHGEF 6 and ARHGEF 7 was not affected by ARHGEF 6 deltaaa56 83 but did not occur with ARHGEF 6 deltaaa396 776 . ^^^ In contrast , it seems that only the coiled coil domain is required for the interaction and heterodimerization of ARHGEF 6 and ARHGEF 7 . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Three members of the Cool / Pix family have shown distinct regulatory activities : ( 1 ) p 50 ( Cool 1 ) inhibits Cdc42 / Rac stimulated PAK activity , ( 2 ) p 85 ( Cool 1 ) / beta Pix has a permissive effect on Cdc42 / Rac stimulated activity , and ( 3 ) p 90 ( Cool 2 ) / alpha Pix strongly activates PAK . ^^^ Rather , an 18 amino acid region , designated T 1 , that is present in the Cool 1 proteins , but missing in Cool 2 , is essential for controlling the regulation of PAK activity by Cool 1 / beta Pix in vivo . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| In addition , we examined the gene expression profile in another set of 30 gastric samples , but no significant over expression of either the beta PIX gene or the alpha PIX gene was found . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| During this analysis , we have compared the expression pattern in the mouse of four genes from the latter class of MRX genes : Ophn 1 , Arhgef 6 ( also called alphaPix ) , Pak 3 , and Gdi 1 . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Three of the encoded proteins , oligophrenin 1 , PAK 3 and alphaPix , interact directly with Rho GTPases . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Four genes from HSAXp ( TM4SF2 , RSK2 / RPS6KA3 , NLGN 4 , ARX ) map to GGA1q13 > q 31 , and seven genes from HSAXq ( OPHN 1 , AGTR 2 , ARHGEF 6 , PAK 3 , FACL4 / ACS4 , FMR 2 , ATRX ) to GGA4p . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Two of the gene products , alpha p 21 activated kinase ( PAK ) interacting exchange factor ( alphaPIX ) and PAK 3 , form a complex with the synaptic adaptor protein G protein coupled receptor kinase interacting protein 1 ( GIT 1 ) . ^^^ Our results point to a signaling complex , consisting of GIT 1 , PIX , Rac , and PAK , that plays an essential role in the regulation of dendritic spine and synapse formation and provides a potential mechanism by which alphaPIX and PAK 3 mutations affect cognitive functions in mental retardation . . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| In cells , p 50 ( Cool 1 ) suppresses Pak activation by upstream activators ; p 85 ( Cool 1 ) has a permissive effect on Pak activation , and we now show that the closely related Cool 2 stimulates Pak kinase activity . ^^^ Cat 1 and Cat 2 both bind to the COOH terminal region of p 85 ( Cool 1 ) and p 85 ( Cool 2 ) but do not bind to p 50 ( Cool 1 ) . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Ptena and ptenb genes play distinct roles in zebrafish embryogenesis . ^^^ Here we have identified two zebrafish orthologs , ptena and ptenb , of the single mammalian PTEN gene and analyzed the role of these genes in zebrafish development . ^^^ By 48 hpf , ptena and ptenb were expressed predominantly in the central nervous system , branchial arches , pectoral fins , and eye . ^^^ Antisense morpholinos were used to knock down translation of ptena and ptenb mRNA in zebrafish embryos . ^^^ Knockdown of either pten gene caused increased levels of phosphorylated Akt in morphant embryos , indicating that Ptena and Ptenb each possess PIP ( 3 ) lipid phosphatase activity . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Eight genes involved in nonspecific 10 linked MR have been identified so far , including FMR 2 , OPHN 1 , GDI 1 , PAK 3 , IL1RAPL , TM4SF2 , VCX A , and ARHGEF 6 . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| The gene for ARHGEF 6 ( also known as alphaPIX or Cool 2 ) , a newly identified guanine nucleotide exchange factor , was identified as a potential candidate XLMR gene , due to its location within the BFLS and MRX 27 critical regions and its function in the regulation of PAK 3 ( a known MRX gene ) . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Eight genes involved in nonspecific 10 linked mental retardation have been identified so far , including FMR 2 , GDI 1 , OPHN 1 , PAK 3 , ARHGEF 6 , IL1RAPL , TM4SF2 , and FACL 4 . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Recent human genetic approaches showed that mutations in three genes encoding OPHN 1 , PAK 3 , and alphaPIX cause nonspecific 10 linked mental retardation . ^^^ |
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| Interacting proteins: Q5ZEZ2 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Secondly , the relative prevalence of genes causing only non syndromic mental retardation ( IL1RAPL1 , TM4SF2 , ZNF 41 , FTSJ 1 , DLG 3 , FACL 4 , PAK 3 , ARHGEF 6 , FMR 2 , and GDI ) is summarised . ^^^ |
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