| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| Overall , these findings highlight novel mechanisms by which extracellular signals can direct the specific activation of Rac versus Cdc 42 by Cool 2 / alpha Pix . . ^^^ |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| The Cool 2 / alpha Pix protein mediates a Cdc 42 Rac signaling cascade . ^^^ |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| Integrin linked kinase activity regulates Rac and Cdc 42 mediated actin cytoskeleton reorganization via alpha PIX . ^^^ |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| Using an active , truncated form of alphaPix ( amino acids 155 545 ) , we observe stimulation of Pak 1 kinase activity when alphaPix 155 545 is co expressed with Cdc 42 and wild type Pak 1 in COS 1 cells . ^^^ However , the Pak 1 ( H 83 , 86L ) mutant that does not bind Rac or Cdc 42 is activated in the absence of GTPase by alphaPix 155 545 and by a mutant of alphaPix 155 545 that no longer has exchange factor activity . ^^^ Pak 1 activity stimulated in vitro using GTPgammaS loaded Cdc 42 was also enhanced by recombinant alphaPix 155 545 in a binding dependent manner . ^^^ |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| The first CH domain of affixin activates Cdc 42 and Rac 1 through alphaPIX , a Cdc42 / Rac1 specific guanine nucleotide exchanging factor . ^^^ The involvement of alphaPIX in the RP 1 induced Cdc 42 activation was demonstrated by the significant dominant negative effect of a point mutant of alphaPIX , alphaPIX ( L383R , L384S ) , lacking GEF activity . ^^^ |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15052 and P60953 |
Pubmed |
SVM Score :0.0 |
| NA |
|