| Interacting proteins: O75914 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Recent human genetic approaches showed that mutations in three genes encoding OPHN 1 , PAK 3 , and alphaPIX cause nonspecific 10 linked mental retardation . ^^^ |
|
| Interacting proteins: O75914 and Q15052 |
Pubmed |
SVM Score :0.0 |
| During this analysis , we have compared the expression pattern in the mouse of four genes from the latter class of MRX genes : Ophn 1 , Arhgef 6 ( also called alphaPix ) , Pak 3 , and Gdi 1 . ^^^ |
|
| Interacting proteins: O75914 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Eight genes involved in nonspecific 10 linked MR have been identified so far , including FMR 2 , OPHN 1 , GDI 1 , PAK 3 , IL1RAPL , TM4SF2 , VCX A , and ARHGEF 6 . ^^^ |
|
| Interacting proteins: O75914 and Q15052 |
Pubmed |
SVM Score :0.0 |
| The gene for ARHGEF 6 ( also known as alphaPIX or Cool 2 ) , a newly identified guanine nucleotide exchange factor , was identified as a potential candidate XLMR gene , due to its location within the BFLS and MRX 27 critical regions and its function in the regulation of PAK 3 ( a known MRX gene ) . ^^^ |
|
| Interacting proteins: O75914 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Eight genes involved in nonspecific 10 linked mental retardation have been identified so far , including FMR 2 , GDI 1 , OPHN 1 , PAK 3 , ARHGEF 6 , IL1RAPL , TM4SF2 , and FACL 4 . ^^^ |
|
| Interacting proteins: O75914 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Three of the encoded proteins , oligophrenin 1 , PAK 3 and alphaPix , interact directly with Rho GTPases . ^^^ |
|
| Interacting proteins: O75914 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Four genes from HSAXp ( TM4SF2 , RSK2 / RPS6KA3 , NLGN 4 , ARX ) map to GGA1q13 > q 31 , and seven genes from HSAXq ( OPHN 1 , AGTR 2 , ARHGEF 6 , PAK 3 , FACL4 / ACS4 , FMR 2 , ATRX ) to GGA4p . ^^^ |
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| Interacting proteins: O75914 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Two of the gene products , alpha p 21 activated kinase ( PAK ) interacting exchange factor ( alphaPIX ) and PAK 3 , form a complex with the synaptic adaptor protein G protein coupled receptor kinase interacting protein 1 ( GIT 1 ) . ^^^ Our results point to a signaling complex , consisting of GIT 1 , PIX , Rac , and PAK , that plays an essential role in the regulation of dendritic spine and synapse formation and provides a potential mechanism by which alphaPIX and PAK 3 mutations affect cognitive functions in mental retardation . . ^^^ |
|
| Interacting proteins: O75914 and Q15052 |
Pubmed |
SVM Score :0.0 |
| Secondly , the relative prevalence of genes causing only non syndromic mental retardation ( IL1RAPL1 , TM4SF2 , ZNF 41 , FTSJ 1 , DLG 3 , FACL 4 , PAK 3 , ARHGEF 6 , FMR 2 , and GDI ) is summarised . ^^^ |
|
| Interacting proteins: O75914 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75914 and Q15052 |
Pubmed |
SVM Score :0.0 |
| NA |
|