| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :1.3115946 |
| We have used recombinant fragments of titin covering the thick filament region to investigate their interaction with myosin binding protein C ( MyBP C ) from skeletal and cardiac muscle . 1.3115946^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| Cardiac MyBP C is arrayed transversely in sarcomere A bands and binds myosin heavy chain in thick filaments and titin in elastic filaments . ^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| The genes coding for different types of collagens , laminins , fibronectin , fibrillins , desmin , titin , alpha actinin , vinculin , cardiac and skeletal alpha actins , ankyrin and spectrin were excluded as responsible for FHC . . ^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| This is the first report of a disease associated missense mutation in MyBP C which does not affect the myosin or titin binding domains . . ^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| We have created transgenic mice in which varying amounts of a mutated MyBP C , lacking the myosin and titin binding domains , are expressed in the heart . ^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| The relationship between myosin binding proteins ( MyBPs ) C and H is confirmed , and MyBP H is proposed to have given rise to MyBP C by the acquisition of some titin domains . . ^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| MyBP C contains myosin and titin binding sites at the C terminus of the molecule in all 3 of the isoforms ( slow skeletal , fast skeletal , and cardiac ) . ^^^ The following 2 major functions of MyBP C have been suggested : ( 1 ) a role in the formation of the sarcomeric myofibril as a result of binding to myosin and titin and ( 2 ) in the case of the cardiac isoform , regulation of contraction through phosphorylation . ^^^ The first is supported by the demonstrated effect of MyBP C on the packing of myosin in the thick filament , the coincidence of appearance of sarcomeres and MyBP C during myofibrillogenesis , and the defective formation of sarcomeres when the titin and / or myosin binding sites of MyBP C are missing . ^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| Although some MyBP C lesions are the result of missense mutations , most show truncated polypeptides lacking either the myosin or myosin and titin binding sites . ^^^ Previously , we generated transgenic ( TG ) mice with cardiac specific expression of a MyBP C mutant lacking the myosin and titin binding domains . ^^^ In contrast to the previous data for the MyBP C lacking both titin and myosin binding sites , only very modest levels of protein were found , consistent with data obtained from human biopsies in which mutated MyBP C could not be detected . ^^^ |
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| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| In contrast , titin , then myomesin and finally C protein ( MyBP C ) gradually form a regularly arranged scaffold on stress fiber like structures ( SFLS ) , on non striated myofibrils ( NSMF ) and on nascent striated myofibrils ( naSMF ) . ^^^ |
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| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| Despite extensive knowledge of many muscle A band proteins ( myosin molecules , titin , C protein ( MyBP C ) ) , details of the organization of these molecules to form myosin filaments remain unclear . ^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| Previously , we prepared mice carrying a mutated MyBP C lacking both the titin and myosin binding sites at the carboxyl terminus . ^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| The loss of several key interactions conserved in the CD loop of the IgI fold is assumed to be responsible for the low stability of cC 5 compared to other IgI domains from titin and MyBP C itself . ^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| While some regions of the MyBPC molecule have been assigned a function in the regulation of muscle contraction , the interaction of other regions with various parts of the myosin molecule and the sarcomeric proteins , actin and titin , remain obscure . ^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| Mutations in 9 different disease genes ( MYH 7 , TNNT 2 , TPM 1 , MYBPC 3 , MYL 3 , MYL 2 , TNNI 3 , CACT and TTN ) cause HCM , while mutations in 3 different genes ( CACT , DES and DMD ) cause DCM in adults . ^^^ |
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| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| The third new mutation leads to a MYBPC 3 lacking titin and myosin binding sites . ^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| Molecular genetic studies have identified eleven genes that code proteins of the sarcomere that are associated with the HCM ; the beta myosin heavy chain gene ( MYH 7 ) , alpha myosin heavy chain ( MYH 6 ) , cardiac troponin T ( TNNT 2 ) ; cardiac troponin C ( TNNC 1 ) , alpha tropomyosin ( TPM 1 ) , myosin binding protein C ( MYBPC 3 ) , cardiac troponin ( TNNI 3 ) , essential and regulatory light chain genes ( MYL 3 and MYL 2 , respectively ) , cardiac alpha actin gene ( ACTC ) and titin ( TTN ) . ^^^ |
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| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| By the use of SDS PAGE , the behavior of titin and MyBP C in fast ( m . psoas ) as well as titin and MyBP 10 in slow ( m . soleus ) muscles of ground squirrels ( Citellus undulatus ) during hibernation was compared with the behavior of titin and MyBP 10 in rat m . soleus under conditions of simulated microgravity . ^^^ A decrease in the amount of titin 1 and MyBP C relative to that of myosin heavy chains by approximately 30 % and approximately 40 % , correspondingly , in muscles of hibernating and arousing ground squirrels was revealed in comparison with active animals . ^^^ |
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| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| The DCM mutations reviewed here are those of the beta myosin heavy chain ( beta MHC ) , myosin binding protein C ( MyBP C ) , actin , alpha tropomyosin ( Tm ) , troponin T ( TnT ) , troponin 1 ( TnI ) , troponin C ( TnC ) , of the sarcomere , and titin , T cap , desmin , vinculin , and muscle LIM protein ( MLP ) of the cytoskeleton . . ^^^ |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14896 and Q8WZ42 |
Pubmed |
SVM Score :0.0 |
| NA |
|